$89 Cheap American Airlines flights Denver (DEN) to St. Louis (STL)

You’ll discover affordable round-trip American Airlines flights from $168 from DEN to STL by organizing your results from “Price (lowest to highest)” on Expedia. Or look for bargains from $89 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to St. Louis tend to be cheaper in the quieter months of January and February. Whether you’re in search of a return or one-way ticket, you could score a better deal then.

Start searching one to three months ahead of your travel date to score cheaper fares on American Airlines flights from Denver Intl. Airport (DEN) to Lambert-St. Louis Intl. Airport (STL). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing spot on, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on our “Nonstop” filter when browsing for direct American Airlines flights from DEN to STL. It’s also a great way to compare other carriers servicing the same direct route.

Sort your results by “Morning” and “Early Morning” to see the earliest departures from DEN to STL. Heading off early means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Hop on an American Airlines flight from Denver Intl. Airport (DEN) to St. Louis, and you’re most likely to touch down at Lambert-St. Louis Intl. Airport (STL). This is the airline’s main hub in this destination.

Depending on your fare type, a fee may apply if you cancel or reschedule your booking more than 24 hours after it has been confirmed. To secure tickets with more flexibility, select our “Changes included” and “No cancel fee” boxes while searching for flights. For more details on modifying or canceling your reservation, go to “Trips,” select your flight and tick “Manage Booking.”