$80 Cheap American Airlines flights Indianapolis (IND) to Knoxville (TYS)

Apply the "Price (lowest to highest)" filter on Expedia to look for cheap American Airlines round-trip flights from $175 from IND to TYS. Affordable one-way tickets from $80 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months ahead of your departure date to get cheaper fares on American Airlines flights from Indianapolis Intl. Airport (IND) to McGhee Tyson Airport (TYS). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from IND to TYS with American Airlines, filter your search by "Early Morning" and "Morning." Choosing an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.