$110 Cheap American Airlines flights Myrtle Beach (MYR) to Detroit (DTW)

Landing cheap one-way American Airlines flights from MYR to DTW from $110 on Expedia is simple — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly return fares from $219 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Detroit tend to be cheaper in the off-peak months of January and February. Whether you need a one-way or round-trip ticket, you could find a better deal then.

Search for cheap American Airlines flights from Myrtle Beach Intl. Airport (MYR) to Detroit Metropolitan Wayne County Airport (DTW) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and itinerary, the best day of the week to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Fill in your dates, hit search and tick the “Nonstop” filter on Expedia to find any direct flights from MYR to DTW with American Airlines or other airlines.

To find the earliest departure from MYR to DTW with American Airlines, sort your results by “Early Morning” and “Morning.” Choosing an early flight generally means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Detroit Metropolitan Wayne County Airport (DTW) is the main Detroit hub for American Airlines flights from Myrtle Beach Intl. Airport (MYR).

Changes are often free within 24 hours of making your booking, but your airline may charge you after that time. For further details about modifying your flights, check out your “Trips,” select your flight and click on “Manage Booking.” If you’d like the freedom to adjust your plans without additional charges, apply the “No cancel fee” or “Changes included” filter when organizing your next break.