$144 Cheap Delta flights Des Moines (DSM) to San Diego (SAN)

Finding cheap one-way Delta Air Lines flights from DSM to SAN from $144 on Expedia is a cinch --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $287 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap Delta Air Lines fares from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence what you pay. Sunday tends to be the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from DSM to SAN with Delta Air Lines, filter your search by "Early Morning" and "Morning." Choosing an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Jetting off from DSM to SAN with Delta Air Lines means enjoying a range of perks, such as an excellent in-flight experience and a rewarding loyalty program. Plus, when booking through Expedia, One Key™ members can collect OneKeyCash™* to use on select future travel purchases. That's on top of the Delta SkyMiles points you can earn with Delta Air Lines.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.