$100 Cheap Delta flights St. Louis (STL) to Knoxville (TYS)

View $100 flight on Sun, Aug 31, 2025Opens in a new window

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$100 Cheap Delta flights St. Louis (STL) to Knoxville (TYS)

Prices were available within the past 7 days and start at $100 for one-way flights and $214 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Nov 27 - Tue, Dec 9
STL
St. Louis
TYS
Knoxville
$214 Roundtrip, found 2 days ago
$214
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Nov 27 from St. Louis to Knoxville, returning Tue, Dec 9, priced at $214 found 2 days ago
Delta
Sun, Aug 31 - Thu, Sep 11
STL
St. Louis
TYS
Knoxville
$223 Roundtrip, found 3 days ago
$223
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Aug 31 from St. Louis to Knoxville, returning Thu, Sep 11, priced at $223 found 3 days ago
Delta
Tue, Aug 12 - Sun, Aug 31
STL
St. Louis
TYS
Knoxville
$227 Roundtrip, found 6 days ago
$227
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Aug 12 from St. Louis to Knoxville, returning Sun, Aug 31, priced at $227 found 6 days ago
Delta
Tue, Nov 25 - Thu, Nov 27
STL
St. Louis
TYS
Knoxville
$243 Roundtrip, found 2 days ago
$243
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 25 from St. Louis to Knoxville, returning Thu, Nov 27, priced at $243 found 2 days ago
Delta
Tue, Aug 5 - Wed, Aug 6
STL
St. Louis
TYS
Knoxville
$251 Roundtrip, just found
$251
Roundtrip
just found
Select Delta flight, departing Tue, Aug 5 from St. Louis to Knoxville, returning Wed, Aug 6, priced at $251 just found
Delta
Mon, Jul 21 - Tue, Aug 5
STL
St. Louis
TYS
Knoxville
$263 Roundtrip, found 2 days ago
$263
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Jul 21 from St. Louis to Knoxville, returning Tue, Aug 5, priced at $263 found 2 days ago
Delta
Sat, Jul 19 - Wed, Jul 23
STL
St. Louis
TYS
Knoxville
$269 Roundtrip, found 21 hours ago
$269
Roundtrip
found 21 hours ago
Select Delta flight, departing Sat, Jul 19 from St. Louis to Knoxville, returning Wed, Jul 23, priced at $269 found 21 hours ago
Flights from St. Louis (STL) to Knoxville (TYS)
Origin airport
Lambert-St. Louis Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Popular airline
Delta
Distance
404 mi

Frequently asked questions

How much is a Delta Air Lines flight from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
Finding cheap one-way Delta Air Lines flights from STL to TYS from $100 on Expedia is a breeze --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $214 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly from STL to TYS with Delta Air Lines?
January is one of the least expensive months to travel to Knoxville with Delta Air Lines. You could also find fantastic deals on one-way and round-trip tickets in December.
What is the cheapest time to book flights from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS) with Delta Air Lines?
To find cheap Delta Air Lines fares from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the price you pay. Sunday is generally the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.
Does Delta Air Lines fly nonstop from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
To figure out if there's a direct journey from STL to TYS with Delta Air Lines or any other airlines, use our "Nonstop" filter when browsing for flights.
What is the earliest Delta Air Lines flight from STL to TYS?
To find the earliest departure from STL to TYS with Delta Air Lines, filter your results by "Morning" and "Early Morning." Choosing an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports does Delta Air Lines fly into in Knoxville?
Delta Air Lines flights from Lambert-St. Louis Intl. Airport (STL) to Knoxville arrive at McGhee Tyson Airport (TYS). This is the main gateway to this destination.
Why fly with Delta Air Lines from STL to TYS?
With a rewarding loyalty program and an excellent in-flight experience, Delta Air Lines is a favorite for many travelers heading from STL to TYS. What's more, if you're a Delta SkyMiles and One Key™ member booking through Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be put toward future getaways.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
Can I change or cancel my Delta Air Lines flight from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
Depending on your fare type, a fee will generally apply if you cancel or change your flight more than 24 hours after confirmation. To secure flexible fares, select our "Changes included" or "No cancel fee" filter when you search for flights. For more information on canceling or modifying your reservation, visit "Trips," select your flight and tick "Manage Booking."

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