$139 Cheap Delta flights Knoxville (TYS) to San Diego (SAN)

Finding cheap one-way Delta Air Lines flights from TYS to SAN from $139 on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $245 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find cheap Delta Air Lines fares from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the overall price. Sunday is generally the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to see the earliest departures from TYS to SAN. Setting off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes traveling from TYS to SAN more enjoyable with a rewarding loyalty program and an excellent in-flight experience. You may even earn points with Delta SkyMiles. Remember to join our free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.