$165 Cheap Delta flights Knoxville (TYS) to San Francisco (SFO)

Scoring cheap one-way Delta Air Lines flights from TYS to SFO from $165 on Expedia is simple — just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $329 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap Delta Air Lines fares from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence what you pay. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to see the earliest flights from TYS to SFO. Heading off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

With a rewarding loyalty program and an excellent in-flight experience, Delta Air Lines is a popular option for many travelers heading from TYS to SFO. Also, if you're a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be spent on future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.