$224 Cheap Delta flights Chicago (MDW) to Knoxville (TYS)

Landing cheap one-way Delta Air Lines flights from MDW to TYS from $224 on Expedia is a cinch --- just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $209 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for affordable Delta Air Lines flights from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) one to three months before your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and journey, the best day to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Early Morning" and "Morning" to browse the earliest flights from MDW to TYS. Heading off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Delta Air Lines makes flying from MDW to TYS more comfortable with an excellent in-flight experience and a rewarding loyalty program. You may even earn points with Delta SkyMiles. Be sure to join our free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.