$155 Cheap Delta flights San Francisco (SFO) to Knoxville (TYS)

Scoring cheap one-way Delta Air Lines flights from SFO to TYS from $155 on Expedia is a cinch — just filter by “Price (lowest to highest).” Alternatively, check out our affordable return fares from $303 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for one-way or round-trip flights to Knoxville in January or December. You could find a cheap fare with Delta Air Lines during these off-season months.

To find cheap Delta Air Lines fares from San Francisco Intl. Airport (SFO) to McGhee Tyson Airport (TYS), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday tends to be the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct journey from SFO to TYS with Delta Air Lines or other carriers, use our “Nonstop” filter when searching for flights.

Filter your results by “Early Morning” and “Morning” to find the earliest flights from SFO to TYS. Jetting off early means you’re 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Catch a Delta Air Lines flight from San Francisco Intl. Airport (SFO) to Knoxville, and you’ll probably touch down at McGhee Tyson Airport (TYS). This is the airline’s primary hub in this destination.

With an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is a popular option for many passengers heading from SFO to TYS. Also, if you’re a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be put toward future getaways.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on the ticket type you purchased, a fee will generally apply if you change or cancel your booking more than 24 hours after confirmation. To find plane tickets with more flexibility, select our “No cancel fee” or “Changes included” filter when you look for flights. For more details on modifying or canceling your reservation, go to “Trips,” select your flight and click on “Manage Booking.”