$160 Cheap Delta flights Tampa (TPA) to Knoxville (TYS)

Use the “Price (lowest to highest)” filter on Expedia to search for cheap Delta Air Lines round-trip flights from $241 from TPA to TYS. Affordable one-way fares from $160 are also on offer.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Delta Air Lines flights to Knoxville are usually cheaper in the low-season months of January and December. Whether you’re after a return or one-way ticket, you could find a better deal then.

Search for affordable Delta Air Lines flights from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS) one to three months prior to your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on our “Nonstop” filter when browsing for direct Delta Air Lines flights from TPA to TYS. You can also compare other airlines servicing the same nonstop trip.

To find the earliest departure from TPA to TYS with Delta Air Lines, sort your results by “Early Morning” and “Morning.” Booking an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Delta Air Lines flights from Tampa Intl. Airport (TPA) to Knoxville come in to McGhee Tyson Airport (TYS). This is the main gateway to this city.

Delta Air Lines makes traveling from TPA to TYS enjoyable with an excellent in-flight experience and a rewarding loyalty program. You could even start earning points with Delta SkyMiles. Remember to sign up to our free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future travel.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on the ticket type you purchased, a fee is typically charged if you cancel or change your booking more than 24 hours after confirmation. To secure flexible fares, select our “No cancel fee” or “Changes included” filter when you look for flights. For additional information on modifying or canceling your reservation, go to “Trips,” select your flight and click on “Manage Booking.”