$109 Cheap Flights from San Antonio (SAT) to Knoxville (TYS)

View $109 flight on Fri, Sep 5, 2025Opens in a new window

Popular airlines from San Antonio International Airport (SAT) to McGhee Tyson Airport (TYS)

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from San Antonio to Knoxville (SAT-TYS)

Prices were available within the past 7 days and start at $109 for one-way flights and $212 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Sep 5 - Sat, Sep 6
SAT
San Antonio
TYS
Knoxville
$212 Roundtrip, found 2 hours ago
$212
Roundtrip
found 2 hours ago
Select United flight, departing Fri, Sep 5 from San Antonio to Knoxville, returning Sat, Sep 6, priced at $212 found 2 hours ago
American Airlines
Tue, Nov 11 - Sat, Nov 15
SAT
San Antonio
TYS
Knoxville
$217 Roundtrip, found 2 hours ago
$217
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Nov 11 from San Antonio to Knoxville, returning Sat, Nov 15, priced at $217 found 2 hours ago
American Airlines
Wed, Oct 29 - Sat, Nov 1
SAT
San Antonio
TYS
Knoxville
$222 Roundtrip, found 1 day ago
$222
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 29 from San Antonio to Knoxville, returning Sat, Nov 1, priced at $222 found 1 day ago
United
Wed, Jan 14 - Wed, Feb 4
SAT
San Antonio
TYS
Knoxville
$232 Roundtrip, found 5 days ago
$232
Roundtrip
found 5 days ago
Select United flight, departing Wed, Jan 14 from San Antonio to Knoxville, returning Wed, Feb 4, priced at $232 found 5 days ago
United
Sat, Sep 6 - Sat, Sep 13
SAT
San Antonio
TYS
Knoxville
$233 Roundtrip, found 3 hours ago
$233
Roundtrip
found 3 hours ago
Select United flight, departing Sat, Sep 6 from San Antonio to Knoxville, returning Sat, Sep 13, priced at $233 found 3 hours ago
United
Fri, Sep 5 - Sat, Sep 6
SAT
San Antonio
TYS
Knoxville
$236 Roundtrip, found 2 hours ago
$236
Roundtrip
found 2 hours ago
Select United flight, departing Fri, Sep 5 from San Antonio to Knoxville, returning Sat, Sep 6, priced at $236 found 2 hours ago
Delta
Tue, Nov 11 - Sat, Nov 15
SAT
San Antonio
TYS
Knoxville
$237 Roundtrip, found 2 hours ago
$237
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Nov 11 from San Antonio to Knoxville, returning Sat, Nov 15, priced at $237 found 2 hours ago
United
Fri, Sep 5 - Sat, Sep 6
SAT
San Antonio
TYS
Knoxville
$237 Roundtrip, found 2 hours ago
$237
Roundtrip
found 2 hours ago
Select United flight, departing Fri, Sep 5 from San Antonio to Knoxville, returning Sat, Sep 6, priced at $237 found 2 hours ago
Frontier Airlines
Sat, Sep 6 - Thu, Sep 25
SAT
San Antonio
TYS
Knoxville
$238 Roundtrip, found 1 hour ago
$238
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sat, Sep 6 from San Antonio to Knoxville, returning Thu, Sep 25, priced at $238 found 1 hour ago
Southwest Airlines
Tue, Mar 10 - Sat, Mar 14
SAT
San Antonio
TYS
Knoxville
$297 Roundtrip, found 2 days ago
$297
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Tue, Mar 10 from San Antonio to Knoxville, returning Sat, Mar 14, priced at $297 found 2 days ago

Find the cheapest month to fly from San Antonio (SAT) to Knoxville (TYS)

November is typically the cheapest month to fly

From $198 - $548 per traveler.

Graph displaying average flight prices per month

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $238
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $238
Flights from San Antonio (SAT) to Knoxville (TYS)
Origin airport
San Antonio Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$212
Distance
946 mi

San Antonio to Knoxville Flights

The cheapest times to fly from San Antonio to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Antonio to Knoxville are during the month of September. You can find some of the cheapest flights from San Antonio to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Antonio to Knoxville

Sunday is one of the best days to book for cheap flights from San Antonio to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Antonio to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Antonio to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $109 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Antonio to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Antonio to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $109 or cheap return flight from $212 from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS)?
September is the cheapest month to fly from SAT to TYS. Avoiding peak travel times is often the key to finding better deals on flights.
What is the cheapest airline that flies from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest SAT to TYS flight.
How many flights per day from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS)?
Direct flights from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SAT to TYS?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS) route, travel before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS) last-minute?
Booking your ticket from SAT to TYS right before your getaway is typically more expensive. But if there's some wiggle room with your departure dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a SAT to TYS flight and hotel package?
You can save money by booking a SAT to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've selected your ideal accommodations and flights, you can add extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from San Antonio Intl. Airport (SAT) to McGhee Tyson Airport (TYS)?
In most cases, you're able to reschedule or cancel your SAT to TYS flight. However, there may be additional charges, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you want more information, head to our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.