$95 Cheap Flights from Tampa (TPA) to Knoxville (TYS)

View $95 flight on Wed, Mar 18, 2026Opens in a new window

Popular airlines from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)

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Cheap Flights from Tampa to Knoxville (TPA-TYS)

Prices were available within the past 7 days and start at $95 for one-way flights and $224 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Mar 3 - Tue, Mar 17
TPA
Tampa
TYS
Knoxville
$224 Roundtrip, found 4 days ago
$224
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Mar 3 from Tampa to Knoxville, returning Tue, Mar 17, priced at $224 found 4 days ago
United
Fri, Jan 23 - Sat, Jan 24
TPA
Tampa
TYS
Knoxville
$244 Roundtrip, found 2 days ago
$244
Roundtrip
found 2 days ago
Select United flight, departing Fri, Jan 23 from Tampa to Knoxville, returning Sat, Jan 24, priced at $244 found 2 days ago
Frontier Airlines
Sun, Aug 24 - Mon, Aug 25
TPA
Tampa
TYS
Knoxville
$248 Roundtrip, found 1 hour ago
$248
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sun, Aug 24 from Tampa to Knoxville, returning Mon, Aug 25, priced at $248 found 1 hour ago
American Airlines
Tue, Dec 30 - Tue, Jan 6
TPA
Tampa
TYS
Knoxville
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 30 from Tampa to Knoxville, returning Tue, Jan 6, priced at $249 found 1 day ago
American Airlines
Fri, Oct 3 - Mon, Oct 6
TPA
Tampa
TYS
Knoxville
$251 Roundtrip, found 1 hour ago
$251
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Oct 3 from Tampa to Knoxville, returning Mon, Oct 6, priced at $251 found 1 hour ago
American Airlines
Sat, Sep 6 - Sun, Sep 7
TPA
Tampa
TYS
Knoxville
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Sep 6 from Tampa to Knoxville, returning Sun, Sep 7, priced at $259 found 2 days ago
Delta
Fri, Oct 3 - Mon, Oct 6
TPA
Tampa
TYS
Knoxville
$261 Roundtrip, found 1 hour ago
$261
Roundtrip
found 1 hour ago
Select Delta flight, departing Fri, Oct 3 from Tampa to Knoxville, returning Mon, Oct 6, priced at $261 found 1 hour ago
United
Fri, Jan 23 - Sat, Jan 24
TPA
Tampa
TYS
Knoxville
$269 Roundtrip, found 2 days ago
$269
Roundtrip
found 2 days ago
Select United flight, departing Fri, Jan 23 from Tampa to Knoxville, returning Sat, Jan 24, priced at $269 found 2 days ago
United
Sat, Sep 13 - Wed, Sep 17
TPA
Tampa
TYS
Knoxville
$271 Roundtrip, found 6 days ago
$271
Roundtrip
found 6 days ago
Select United flight, departing Sat, Sep 13 from Tampa to Knoxville, returning Wed, Sep 17, priced at $271 found 6 days ago
Southwest Airlines
Sat, Mar 14 - Wed, Mar 18
TPA
Tampa
TYS
Knoxville
$283 Roundtrip, found 1 day ago
$283
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Sat, Mar 14 from Tampa to Knoxville, returning Wed, Mar 18, priced at $283 found 1 day ago

Find the cheapest month to fly from Tampa (TPA) to Knoxville (TYS)

November is typically the cheapest month to fly

From $148 - $438 per traveler.

Graph displaying average flight prices per month

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $310
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $310
Flights from Tampa (TPA) to Knoxville (TYS)
Origin airport
Tampa Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$223
Distance
547 mi

Tampa to Knoxville Flights

The cheapest times to fly from Tampa to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tampa to Knoxville are during the month of March. You can find some of the cheapest flights from Tampa to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tampa to Knoxville

Sunday is one of the best days to book for cheap flights from Tampa to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tampa to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tampa to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $95 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tampa to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tampa to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $95 or cheap return flight from $224 from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)?
Traveling in March is a good way to save, as it's the cheapest month for flights between TPA and TYS. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest TPA to TYS flight.
How many flights per day from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)?
You'll have to take a flight with a layover when traveling from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from TPA to TYS?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)?
Select a flight from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from TPA to TYS are typically more expensive. To secure the best prices, start looking for flights well in advance. That being said, if you're flexible with your travel plans, you may score a cheap fare right before your journey.
Is it cheaper to book a TPA to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a TPA to TYS flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place takes the hassle out of planning your trip. Simply secure your flights and select from our wide range of stays, then tailor your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS)?
If you booked your TPA to TYS flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.