$70 Cheap Flights from San Diego (SAN) to Knoxville (TYS)

View $70 flight on Mon, Dec 15, 2025Opens in a new window

Popular airlines from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)

Cheap Flights from San Diego to Knoxville (SAN-TYS)

Prices were available within the past 7 days and start at $70 for one-way flights and $140 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Mon, Dec 8 - Mon, Dec 15
SAN
San Diego
TYS
Knoxville
$140 Roundtrip, found 20 hours ago
$140
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Mon, Dec 8 from San Diego to Knoxville, returning Mon, Dec 15, priced at $140 found 20 hours ago
Frontier Airlines
Mon, Dec 8 - Thu, Dec 11
SAN
San Diego
TYS
Knoxville
$147 Roundtrip, found 1 hour ago
$147
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, Dec 8 from San Diego to Knoxville, returning Thu, Dec 11, priced at $147 found 1 hour ago
Frontier Airlines
Sun, Dec 7 - Mon, Dec 8
SAN
San Diego
TYS
Knoxville
$154 Roundtrip, just found
$154
Roundtrip
just found
Select Frontier Airlines flight, departing Sun, Dec 7 from San Diego to Knoxville, returning Mon, Dec 8, priced at $154 just found
Frontier Airlines
Thu, Dec 11 - Mon, Dec 15
SAN
San Diego
TYS
Knoxville
$160 Roundtrip, found 1 day ago
$160
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Dec 11 from San Diego to Knoxville, returning Mon, Dec 15, priced at $160 found 1 day ago
Frontier Airlines
Thu, Nov 13 - Thu, Dec 4
SAN
San Diego
TYS
Knoxville
$180 Roundtrip, found 5 days ago
$180
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Nov 13 from San Diego to Knoxville, returning Thu, Dec 4, priced at $180 found 5 days ago
Frontier Airlines
Sun, Dec 14 - Mon, Dec 15
SAN
San Diego
TYS
Knoxville
$192 Roundtrip, found 1 day ago
$192
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Dec 14 from San Diego to Knoxville, returning Mon, Dec 15, priced at $192 found 1 day ago
American Airlines
Wed, Feb 25 - Tue, Mar 17
SAN
San Diego
TYS
Knoxville
$275 Roundtrip, found 6 days ago
$275
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Feb 25 from San Diego to Knoxville, returning Tue, Mar 17, priced at $275 found 6 days ago
Delta
Wed, Dec 3 - Tue, Dec 9
SAN
San Diego
TYS
Knoxville
$277 Roundtrip, just found
$277
Roundtrip
just found
Select Delta flight, departing Wed, Dec 3 from San Diego to Knoxville, returning Tue, Dec 9, priced at $277 just found
United
Tue, May 12 - Sat, May 30
SAN
San Diego
TYS
Knoxville
$277 Roundtrip, found 5 hours ago
$277
Roundtrip
found 5 hours ago
Select United flight, departing Tue, May 12 from San Diego to Knoxville, returning Sat, May 30, priced at $277 found 5 hours ago
Alaska Airlines
Tue, Feb 17 - Sat, Feb 21
SAN
San Diego
TYS
Knoxville
$367 Roundtrip, found 13 hours ago
$367
Roundtrip
found 13 hours ago
Select Alaska Airlines flight, departing Tue, Feb 17 from San Diego to Knoxville, returning Sat, Feb 21, priced at $367 found 13 hours ago

Find the cheapest month to fly from San Diego (SAN) to Knoxville (TYS)

January is typically the cheapest month to fly

From $178 - $599 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $557
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $557

Frequently asked questions

How much does a flight from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $70 or cheap return flight from $140 from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)?
December is the cheapest month to fly from SAN to TYS. Traveling during an off-peak travel window is often the key to better flight prices.
What is the cheapest airline that flies from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest SAN to TYS flight.
How many flights per day from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)?
You'll need to take a flight with a layover if you're traveling from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from SAN to TYS?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) route, aim to fly before 3 PM. Departures after this hour have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) last-minute?
Booking your ticket from SAN to TYS right before your getaway is generally more expensive. But if you're flexible with your departure dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a SAN to TYS flight and hotel package?
You'll generally save money by booking a SAN to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've chosen your preferred flights and accommodations, consider adding extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS)?
Generally, it's possible to cancel or reschedule your SAN to TYS flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
San Diego Intl.
Destination airport
McGhee Tyson
Airlines serving
Alaska Airlines, American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$140
Distance
1898 mi

Book with confidence

San Diego to Knoxville Flights

The cheapest times to fly from San Diego to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Diego to Knoxville are during the month of December. You can find some of the cheapest flights from San Diego to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Diego to Knoxville

Sunday is one of the best days to book for cheap flights from San Diego to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Diego to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Diego to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $70 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Diego to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Diego to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

San Diego to Knoxville Flights

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*Available to One Key members.