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$163 Cheap Flights from Buffalo (BUF) to Panama City (ECP)

View $163 flight on Thu, Sep 24, 2026Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Northwest Florida Beaches Intl. Airport (ECP)

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Cheap Flights from Buffalo to Panama City (BUF-ECP)

Prices were available within the past 7 days and start at $163 for one-way flights and $325 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 21 - Mon, Oct 26
BUF
Buffalo
ECP
Panama City
$325 Roundtrip, found 9 hours ago
$325
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 21 from Buffalo to Panama City, returning Mon, Oct 26, priced at $325 found 9 hours ago
Delta
Thu, Sep 24 - Wed, Sep 30
BUF
Buffalo
ECP
Panama City
$325 Roundtrip, just found
$325
Roundtrip
just found
Select Delta flight, departing Thu, Sep 24 from Buffalo to Panama City, returning Wed, Sep 30, priced at $325 just found
Southwest Airlines
Thu, Oct 29 - Wed, Nov 4
BUF
Buffalo
ECP
Panama City
$330 Roundtrip, found 1 day ago
$330
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Thu, Oct 29 from Buffalo to Panama City, returning Wed, Nov 4, priced at $330 found 1 day ago
Delta
Thu, Sep 24 - Wed, Sep 30
BUF
Buffalo
ECP
Panama City
$336 Roundtrip, just found
$336
Roundtrip
just found
Select Delta flight, departing Thu, Sep 24 from Buffalo to Panama City, returning Wed, Sep 30, priced at $336 just found
American Airlines
Sat, Oct 17 - Fri, Oct 23
BUF
Buffalo
ECP
Panama City
$338 Roundtrip, found 2 hours ago
$338
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, Oct 17 from Buffalo to Panama City, returning Fri, Oct 23, priced at $338 found 2 hours ago
Southwest Airlines
Mon, Nov 9 - Sat, Nov 14
BUF
Buffalo
ECP
Panama City
$341 Roundtrip, found 14 hours ago
$341
Roundtrip
found 14 hours ago
Select Southwest Airlines flight, departing Mon, Nov 9 from Buffalo to Panama City, returning Sat, Nov 14, priced at $341 found 14 hours ago
American Airlines
Fri, Jan 8 - Fri, Jan 15
BUF
Buffalo
ECP
Panama City
$351 Roundtrip, found 22 hours ago
$351
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Jan 8 from Buffalo to Panama City, returning Fri, Jan 15, priced at $351 found 22 hours ago
American Airlines
Sat, Oct 17 - Fri, Oct 23
BUF
Buffalo
ECP
Panama City
$355 Roundtrip, found 2 hours ago
$355
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, Oct 17 from Buffalo to Panama City, returning Fri, Oct 23, priced at $355 found 2 hours ago
Southwest Airlines
Tue, Oct 20 - Fri, Oct 23
BUF
Buffalo
ECP
Panama City
$356 Roundtrip, found 1 day ago
$356
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, Oct 20 from Buffalo to Panama City, returning Fri, Oct 23, priced at $356 found 1 day ago
United
Sat, Jan 9 - Wed, Jan 13
BUF
Buffalo
ECP
Panama City
$370 Roundtrip, found 13 hours ago
$370
Roundtrip
found 13 hours ago
Select United flight, departing Sat, Jan 9 from Buffalo to Panama City, returning Wed, Jan 13, priced at $370 found 13 hours ago

Find the cheapest month to fly from Buffalo (BUF) to Panama City (ECP)

September is typically the cheapest month to fly

From $262 - $566 per traveler.

What you need to know for your flight from Buffalo Niagara Intl. to Northwest Florida Beaches Intl.

Buffalo (BUF) to Panama City (ECP) at a glance

Explore a variety of options for flights from Buffalo (BUF) to Panama City (ECP) on this domestic short-haul route. You can choose from both full-service and low-cost carriers to discover the itinerary that aligns with your budget and travel plans while taking in Panama City's iconic attractions and neighborhoods. Get all the essential information for your journey from Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP).

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 1h 30m layover with one stop
  • Route distance: roughly 1,000 miles (1,610 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $125–$445, depending on seasonality and how far ahead you book

Flights from Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP)

Based on the latest traveler bookings, here are the top airlines flying from Buffalo to Panama City, primarily favored for their one-stop service. Popular layover options include Charlotte-Douglas International Airport (CLT) with a layover of about 1 hour and 15 minutes, Hartsfield-Jackson Atlanta International Airport (ATL) with approximately 1 hour and 45 minutes, and Midway International Airport (MDW) offering a 1-hour layover. These choices allow you to adjust your itinerary based on price, total travel time, and cabin class.

  • American Airlines: This comprehensive airline provides one-stop service, with one-way ticket prices generally falling between $130 and $385. It represents about 42% of flights on this route, boasting an in-flight duration of 3 hours and 30 minutes, and a total travel time of around 5 hours and 15 minutes, including layover time.
  • Delta: Known for its full-service offerings, Delta provides one-stop service with one-way fares typically ranging from $130 to $575. This airline accounts for roughly 37% of departures on this route, featuring an in-flight time of 3 hours and 30 minutes, and a complete journey duration of about 5 hours and 15 minutes, factoring in layovers.
  • Southwest Airlines: As a budget-friendly option, Southwest Airlines offers one-stop service, with one-way fares usually between $125 and $480. It makes up around 17% of the departures on this route, featuring a flight time of 3 hours and 30 minutes, and an overall journey time of approximately 5 hours and 15 minutes, including layover.
  • United: This full-service airline delivers one-stop service, with one-way fares generally ranging from $175 to $465. United constitutes about 4% of the flights on this route, with an in-flight duration of 3 hours and 30 minutes, and a total travel time of roughly 5 hours and 15 minutes, including layover times.

Best time to fly from Buffalo (BUF) to Panama City (ECP)

The most popular months for travelers flying from Buffalo to Panama City are March, April, and July, when peak temperatures in Panama City reach up to 82.6°F in July. If you prefer quieter travel, consider September, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 79.5°F. For better deals, August usually offers the lowest average one-way fare around $164. Flight availability peaks in December, with approximately 11 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: August usually offers good deals with average one-way fare around $164, roughly 30% cheaper than the yearly average.
  • Another budget-friendly time to fly: October typically offers an average one-way fare of around $166.
  • Most flight options: December has the highest number of flights from Buffalo to Panama City, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January54.1°F (12.3°C)Average8$234
February57.9°F (14.4°C)Average9$271
March62.8°F (17.1°C)High8$250
April68.4°F (20.2°C)High8$273
May75.0°F (23.9°C)Average8$253
June81.1°F (27.3°C)Low9$300
July82.6°F (28.1°C)High9$231
August82.8°F (28.2°C)Average8$164
September79.5°F (26.4°C)Low7$224
October72.0°F (22.2°C)Average8$166
November62.4°F (16.9°C)Average7$199
December58.1°F (14.5°C)Low11$281

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Buffalo (BUF) to Panama City (ECP)

  • Buffalo to Fort Walton Beach (BUF-VPS): Northwest Florida Regional Airport (VPS) is located approximately 46 miles from Northwest Florida Beaches International Airport (ECP). One-way economy fares along this route generally fall between $135 and $405, influenced by the season and timing of the booking. Typically, this route features one-stop flights, with common layover points being Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). Major airlines operating on this route include Delta and American Airlines. Additionally, first-class service is offered on this journey.
  • Rochester to Panama City (ROC-ECP): Greater Rochester International Airport (ROC) is situated roughly 56 miles from Buffalo Niagara International Airport (BUF). One-way economy fares for this journey usually range from $135 to $485, varying with the season and the advance booking time. This route is typically served by one-stop options, with frequent layovers at Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). The leading airlines on this route are Delta and American Airlines. Business and first-class service is also available for travelers.

How to find the best prices for flights from Buffalo (BUF) to Panama City (ECP)

Getting some of the best deals on flights from Buffalo to Panama City is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are typically found when booking 2-8 weeks in advance, which is also when most travelers make their reservations. Evening departures from 6 PM to 12 AM tend to offer lower prices, while morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Tuesday generally provides cheaper options, though Wednesday is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Northwest Florida Beaches International Airport from Buffalo Niagara International Airport

Panama City welcomes travelers from Buffalo with a range of transport options based on price, convenience, and proximity. Here's how to reach Panama City efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Panama City, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Northwest Florida Beaches International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Northwest Florida Beaches International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) cost?
You can find cheap one-way flights from $163 and cheap return flights from $325 Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) with Expedia. One-way flights usually range from $132 to $658, and return flights typically cost between $388 and $1914. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
January is the cheapest month to fly from Buffalo to Panama City, with average return fares around $338. This is about 21% lower than the average price throughout the year, as demand typically drops after the holiday season. Other affordable months to consider are August and October.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Enter BUF to ECP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
To find a cheap flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
For flights from Buffalo (BUF) to Panama City (ECP), January and August are the best months to fly. January features an average price of about $338, making it a cost-effective option, while August is also favorable. These months are ideal for travelers looking to escape the winter chill for a beach getaway.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The earliest flight from Buffalo Niagara International (BUF) to Northwest Florida Beaches International (ECP) usually leaves at around 5:00 AM, operated by American Airlines. This seasonal service is available in February, giving you a great opportunity to enjoy a full day in Florida. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
For flights from Buffalo (BUF) to Panama City (ECP), the most popular departure times are in the early morning, from 6am to 9am. About 44% of passengers prefer this time window. Many major carriers, including American Airlines and Delta Airlines, offer flights during this period. This timing is popular because it allows you to start your day early and enjoy your time in Florida.
How long does it take to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Flights from BUF to ECP with one stop typically take around 7 hours 20 minutes, covering approximately 953 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
First class seats are offered on the BUF to ECP route. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How do I earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight with Expedia?
It's easy to earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Buffalo Niagara Intl. (BUF)?
From Buffalo Niagara Intl. (BUF), you can fly into Northwest Florida Beaches Intl. (ECP) and Tocumen Intl. (PTY) in Panama City. Some flights may connect through major hubs like O'Hare Intl. (ORD), Baltimore Washington Intl. Thurgood Marshall (BWI), Washington Dulles Intl. (IAD) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) at the last minute?
Typically, booking a last minute flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package?
Securing a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
If you booked your Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$324
Distance
952 mi

Book with confidence

Buffalo to Panama City Flights

The cheapest times to fly from Buffalo to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Panama City are during the month of October. You can find some of the cheapest flights from Buffalo to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Panama City

Sunday is one of the best days to book for cheap flights from Buffalo to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $163 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Buffalo to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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