$144 Cheap Flights from Buffalo (BUF) to Knoxville (TYS)

Buffalo (BUF) to Knoxville (TYS) at a glance

Travel from Buffalo (BUF) to Knoxville (TYS) with a selection of airlines operating this domestic short-haul route. Explore options from full-service and low-cost carriers to find the best flight that aligns with your budget and schedule as you plan your visit to discover Knoxville's renowned attractions and neighborhoods. Get all the essential details for your journey from Buffalo Niagara International Airport to McGhee Tyson Airport, and start planning your next flight to Knoxville!

• Fastest flight duration: around 3h 15m in-flight, plus roughly 1h 15m layover with one stop
• Route distance: roughly 600 miles (970 km)
• Flights per week: around 10 departures on average
• Typical fares (one-way): economy tickets often range from $115–$400, depending on seasonality and how far ahead you book

Flights from Buffalo Niagara International Airport (BUF) to McGhee Tyson Airport (TYS)

According to recent traveler bookings, the most popular airlines for flights from Buffalo to Knoxville typically offer one-stop services. Common layover points include LaGuardia Airport (LGA) with an approximately 1 hour and 30-minute stop, Charlotte-Douglas International Airport (CLT) with about a 1-hour layover, and Ronald Reagan Washington National Airport (DCA) with a layover of around 1 hour and 15 minutes. This gives you the flexibility to choose based on price, total travel time, and cabin class to create the ideal itinerary.

• American Airlines: This full-service airline provides one-stop options, with one-way ticket prices generally falling between $125 and $400. It represents about 58% of flights on this route, with a flight duration of 3 hours and 15 minutes and a total travel time of approximately 4 hours and 30 minutes, including layovers.
• Delta: Operating as a full-service airline, Delta offers one-stop services with one-way fares typically in the range of $115 to $435. It makes up around 21% of departures for this route, featuring an in-flight duration of 3 hours and 15 minutes and a total journey time of roughly 4 hours and 30 minutes, including layovers.
• United: Another full-service carrier, United provides one-stop service with one-way fares usually ranging from $115 to $405. It accounts for about 17% of the route's departures, with an in-flight time of 3 hours and 15 minutes and an overall travel duration of approximately 4 hours and 30 minutes, including layovers.
• Southwest Airlines: As a low-cost airline, Southwest offers one-stop services with one-way fares typically priced between $130 and $315. It represents roughly 3% of departures on this route, featuring a flight time of 3 hours and 15 minutes and a total journey time of about 4 hours and 30 minutes, including layovers.

Travelers have the option to upgrade their flight from Buffalo to Knoxville, with American Airlines providing first-class service on this route.

Best time to fly from Buffalo (BUF) to Knoxville (TYS)

The most popular months for travelers flying from Buffalo to Knoxville are March, April, and October, when peak temperatures in Knoxville reach up to 59.5°F in October. If you prefer quieter travel, consider September, the least busy time to visit with temperatures around 70.3°F and typically the lowest average one-way fare (around $160). Flight availability peaks in May and July, with approximately 12 flights per week, making it easier to find convenient departure times. December has the fewest flights, with approximately 7 flights per week.

• Cheapest time to fly: September usually offers good deals with average one-way fare around $160, roughly 25% cheaper than the yearly average.
• Another budget-friendly time to fly: August typically offers an average one-way fare of around $162.
• Most flight options: May and July have the highest number of flights from Buffalo to Knoxville, with approximately 12 flights per week, giving you more flexibility in scheduling your trip.

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Buffalo (BUF) to Knoxville (TYS)

• Rochester to Knoxville (ROC-TYS): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). On this route, one-way economy fares generally fall between $125 and $365, influenced by the season and how far in advance you book. Typically, travelers can expect one-stop flights, with common layover points being Ronald Reagan Washington National Airport (DCA) and LaGuardia Airport (LGA). Major airlines servicing this route include American Airlines and Delta, and first-class service is also offered.

How to find the best prices for flights from Buffalo (BUF) to Knoxville (TYS)

Getting some of the best deals on flights from Buffalo to Knoxville is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Departures in the morning, from 5 a.m. to 12 p.m., often provide lower prices and are also the most popular. Additionally, flying on Wednesday typically offers cheaper options, while Thursday is the busiest travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Knoxville hotel and flight deals.
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at McGhee Tyson Airport from Buffalo Niagara International Airport

Knoxville welcomes travelers from Buffalo with a range of transport options based on price, convenience, and proximity. Knoxville city center is approximately a 20-minute drive (covering about 15 miles) from McGhee Tyson Airport, depending on traffic. Here's how to reach Knoxville efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Knoxville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
• Car rental: Renting a car from McGhee Tyson Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at McGhee Tyson Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Buffalo to Knoxville Flights

The cheapest times to fly from Buffalo to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Knoxville are during the month of October. You can find some of the cheapest flights from Buffalo to Knoxville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Buffalo to Knoxville

Sunday is one of the best days to book for cheap flights from Buffalo to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Buffalo to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.