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$144 Cheap Flights from Buffalo (BUF) to Knoxville (TYS)

View $144 flight on Sat, Oct 24, 2026Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)

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Cheap Flights from Buffalo to Knoxville (BUF-TYS)

Prices were available within the past 7 days and start at $144 for one-way flights and $273 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Sun, Sep 6 - Sat, Sep 12
BUF
Buffalo
TYS
Knoxville
$273 Roundtrip, found 4 days ago
$273
Roundtrip
found 4 days ago
Select United flight, departing Sun, Sep 6 from Buffalo to Knoxville, returning Sat, Sep 12, priced at $273 found 4 days ago
United
Sun, Sep 6 - Sat, Sep 12
BUF
Buffalo
TYS
Knoxville
$275 Roundtrip, found 4 days ago
$275
Roundtrip
found 4 days ago
Select United flight, departing Sun, Sep 6 from Buffalo to Knoxville, returning Sat, Sep 12, priced at $275 found 4 days ago
United
Sun, Sep 6 - Sat, Sep 12
BUF
Buffalo
TYS
Knoxville
$280 Roundtrip, found 4 days ago
$280
Roundtrip
found 4 days ago
Select United flight, departing Sun, Sep 6 from Buffalo to Knoxville, returning Sat, Sep 12, priced at $280 found 4 days ago
American Airlines
Sat, Oct 24 - Tue, Oct 27
BUF
Buffalo
TYS
Knoxville
$287 Roundtrip, found 1 hour ago
$287
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Sat, Oct 24 from Buffalo to Knoxville, returning Tue, Oct 27, priced at $287 found 1 hour ago
Delta
Wed, Oct 28 - Wed, Nov 4
BUF
Buffalo
TYS
Knoxville
$287 Roundtrip, found 3 hours ago
$287
Roundtrip
found 3 hours ago
Select Delta flight, departing Wed, Oct 28 from Buffalo to Knoxville, returning Wed, Nov 4, priced at $287 found 3 hours ago
Southwest Airlines
Wed, Oct 28 - Wed, Nov 4
BUF
Buffalo
TYS
Knoxville
$287 Roundtrip, found 3 hours ago
$287
Roundtrip
found 3 hours ago
Select Southwest Airlines flight, departing Wed, Oct 28 from Buffalo to Knoxville, returning Wed, Nov 4, priced at $287 found 3 hours ago
United
Sun, Sep 6 - Sat, Sep 12
BUF
Buffalo
TYS
Knoxville
$289 Roundtrip, found 4 days ago
$289
Roundtrip
found 4 days ago
Select United flight, departing Sun, Sep 6 from Buffalo to Knoxville, returning Sat, Sep 12, priced at $289 found 4 days ago
United
Sat, Nov 7 - Mon, Nov 9
BUF
Buffalo
TYS
Knoxville
$292 Roundtrip, found 1 hour ago
$292
Roundtrip
found 1 hour ago
Select United flight, departing Sat, Nov 7 from Buffalo to Knoxville, returning Mon, Nov 9, priced at $292 found 1 hour ago
Southwest Airlines
Wed, Oct 28 - Wed, Nov 4
BUF
Buffalo
TYS
Knoxville
$297 Roundtrip, found 3 hours ago
$297
Roundtrip
found 3 hours ago
Select Southwest Airlines flight, departing Wed, Oct 28 from Buffalo to Knoxville, returning Wed, Nov 4, priced at $297 found 3 hours ago
United
Tue, Oct 6 - Sat, Oct 10
BUF
Buffalo
TYS
Knoxville
$301 Roundtrip, found 4 hours ago
$301
Roundtrip
found 4 hours ago
Select United flight, departing Tue, Oct 6 from Buffalo to Knoxville, returning Sat, Oct 10, priced at $301 found 4 hours ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $393
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $393

What you need to know for your flight from Buffalo Niagara Intl. to McGhee Tyson

Buffalo (BUF) to Knoxville (TYS) at a glance

Travel from Buffalo (BUF) to Knoxville (TYS) with a selection of airlines operating this domestic short-haul route. Explore options from full-service and low-cost carriers to find the best flight that aligns with your budget and schedule as you plan your visit to discover Knoxville's renowned attractions and neighborhoods. Get all the essential details for your journey from Buffalo Niagara International Airport to McGhee Tyson Airport, and start planning your next flight to Knoxville!

  • Fastest flight duration: around 3h 15m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 10 departures on average
  • Typical fares (one-way): economy tickets often range from $115–$400, depending on seasonality and how far ahead you book

Flights from Buffalo Niagara International Airport (BUF) to McGhee Tyson Airport (TYS)

According to recent traveler bookings, the most popular airlines for flights from Buffalo to Knoxville typically offer one-stop services. Common layover points include LaGuardia Airport (LGA) with an approximately 1 hour and 30-minute stop, Charlotte-Douglas International Airport (CLT) with about a 1-hour layover, and Ronald Reagan Washington National Airport (DCA) with a layover of around 1 hour and 15 minutes. This gives you the flexibility to choose based on price, total travel time, and cabin class to create the ideal itinerary.

  • American Airlines: This full-service airline provides one-stop options, with one-way ticket prices generally falling between $125 and $400. It represents about 58% of flights on this route, with a flight duration of 3 hours and 15 minutes and a total travel time of approximately 4 hours and 30 minutes, including layovers.
  • Delta: Operating as a full-service airline, Delta offers one-stop services with one-way fares typically in the range of $115 to $435. It makes up around 21% of departures for this route, featuring an in-flight duration of 3 hours and 15 minutes and a total journey time of roughly 4 hours and 30 minutes, including layovers.
  • United: Another full-service carrier, United provides one-stop service with one-way fares usually ranging from $115 to $405. It accounts for about 17% of the route's departures, with an in-flight time of 3 hours and 15 minutes and an overall travel duration of approximately 4 hours and 30 minutes, including layovers.
  • Southwest Airlines: As a low-cost airline, Southwest offers one-stop services with one-way fares typically priced between $130 and $315. It represents roughly 3% of departures on this route, featuring a flight time of 3 hours and 15 minutes and a total journey time of about 4 hours and 30 minutes, including layovers.

Travelers have the option to upgrade their flight from Buffalo to Knoxville, with American Airlines providing first-class service on this route.

Best time to fly from Buffalo (BUF) to Knoxville (TYS)

The most popular months for travelers flying from Buffalo to Knoxville are March, April, and October, when peak temperatures in Knoxville reach up to 59.5°F in October. If you prefer quieter travel, consider September, the least busy time to visit with temperatures around 70.3°F and typically the lowest average one-way fare (around $160). Flight availability peaks in May and July, with approximately 12 flights per week, making it easier to find convenient departure times. December has the fewest flights, with approximately 7 flights per week.

  • Cheapest time to fly: September usually offers good deals with average one-way fare around $160, roughly 25% cheaper than the yearly average.
  • Another budget-friendly time to fly: August typically offers an average one-way fare of around $162.
  • Most flight options: May and July have the highest number of flights from Buffalo to Knoxville, with approximately 12 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January37.8°F (3.2°C)Average9$255
February42.4°F (5.8°C)Average9$223
March49.5°F (9.7°C)High10$242
April57.6°F (14.2°C)High11$206
May66.4°F (19.1°C)Average12$248
June74.1°F (23.4°C)Average11$196
July77.0°F (25.0°C)Average12$212
August75.7°F (24.3°C)Average9$162
September70.3°F (21.3°C)Low10$160
October59.5°F (15.3°C)High9$227
November48.6°F (9.2°C)Low9$229
December43.0°F (6.1°C)Low7$229

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Buffalo (BUF) to Knoxville (TYS)

  • Rochester to Knoxville (ROC-TYS): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). On this route, one-way economy fares generally fall between $125 and $365, influenced by the season and how far in advance you book. Typically, travelers can expect one-stop flights, with common layover points being Ronald Reagan Washington National Airport (DCA) and LaGuardia Airport (LGA). Major airlines servicing this route include American Airlines and Delta, and first-class service is also offered.

How to find the best prices for flights from Buffalo (BUF) to Knoxville (TYS)

Getting some of the best deals on flights from Buffalo to Knoxville is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Departures in the morning, from 5 a.m. to 12 p.m., often provide lower prices and are also the most popular. Additionally, flying on Wednesday typically offers cheaper options, while Thursday is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Knoxville hotel and flight deals.
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at McGhee Tyson Airport from Buffalo Niagara International Airport

Knoxville welcomes travelers from Buffalo with a range of transport options based on price, convenience, and proximity. Knoxville city center is approximately a 20-minute drive (covering about 15 miles) from McGhee Tyson Airport, depending on traffic. Here's how to reach Knoxville efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Knoxville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from McGhee Tyson Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at McGhee Tyson Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) cost?
You can find cheap one-way flights from $144 and cheap return flights from $273 Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) with Expedia. One-way flights usually range from $159 to $641, and return flights typically cost between $333 and $1049. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The cheapest month to fly from BUF to TYS is September when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Enter BUF to TYS and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Southwest Airlines is one of the cheapest airlines offering connecting flights from Buffalo, NY (BUF) to Knoxville, TN (TYS), with round-trip tickets starting from around $419 with a layover in Midway Intl. (MDW). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
To find a cheap flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The earliest flight from Buffalo, NY (BUF) to Knoxville, TN (TYS) usually leaves at around 5:00 AM, operated by American Airlines. This flight is part of a seasonal service available in December, allowing you to start your day early and maximize your time in Knoxville. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The most popular departure times for flights from Buffalo Niagara International Airport (BUF) to Knoxville (TYS) are in the early morning, from 6am to 9am. About 35% of passengers prefer this time window. Many major carriers, including American Airlines, Delta and United Airlines, offer flights during this window. This timing works well because it allows you to arrive in Knoxville with plenty of time to enjoy your day.
How long does it take to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Flying from BUF to TYS with a connection usually takes about 4 hours 50 minutes, traveling roughly 567 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
You can fly first class between BUF and TYS. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia?
It's easy to earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Knoxville from Buffalo Niagara Intl. (BUF)?
If you're planning to travel to Knoxville from Buffalo Niagara Intl. (BUF), you can fly into McGhee Tyson (TYS) Some flights may connect through major hubs like Liberty Intl. (EWR), O'Hare Intl. (ORD), Washington Dulles Intl. (IAD) before reaching Knoxville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) at the last minute?
Typically, booking a last minute flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package?
Securing a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
If you booked your Buffalo, NY (BUF-Buffalo Niagara Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$273
Distance
566 mi

Book with confidence

Buffalo to Knoxville Flights

The cheapest times to fly from Buffalo to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Knoxville are during the month of September. You can find some of the cheapest flights from Buffalo to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Knoxville

Sunday is one of the best days to book for cheap flights from Buffalo to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Buffalo to Knoxville Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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