$308 Cheap Flights from Detroit (DTW) to La Crosse (LSE)

View $308 flight on Fri, Nov 7, 2025Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Detroit to La Crosse (DTW-LSE)

Prices were available within the past 7 days and start at $308 for one-way flights and $468 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Dec 11 - Sun, Dec 14
DTW
Detroit
LSE
La Crosse
$468 Roundtrip, found 1 hour ago
$468
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Thu, Dec 11 from Detroit to La Crosse, returning Sun, Dec 14, priced at $468 found 1 hour ago
American Airlines
Mon, Nov 24 - Fri, Nov 28
DTW
Detroit
LSE
La Crosse
$481 Roundtrip, found 3 days ago
$481
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Nov 24 from Detroit to La Crosse, returning Fri, Nov 28, priced at $481 found 3 days ago
American Airlines
Mon, Nov 24 - Thu, Nov 27
DTW
Detroit
LSE
La Crosse
$487 Roundtrip, found 3 days ago
$487
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Nov 24 from Detroit to La Crosse, returning Thu, Nov 27, priced at $487 found 3 days ago
American Airlines
Sat, Nov 22 - Tue, Nov 25
DTW
Detroit
LSE
La Crosse
$492 Roundtrip, found 3 days ago
$492
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Nov 22 from Detroit to La Crosse, returning Tue, Nov 25, priced at $492 found 3 days ago
American Airlines
Fri, Nov 21 - Fri, Nov 28
DTW
Detroit
LSE
La Crosse
$504 Roundtrip, found 3 days ago
$504
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Nov 21 from Detroit to La Crosse, returning Fri, Nov 28, priced at $504 found 3 days ago
American Airlines
Thu, Nov 27 - Sat, Nov 29
DTW
Detroit
LSE
La Crosse
$508 Roundtrip, found 3 days ago
$508
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 27 from Detroit to La Crosse, returning Sat, Nov 29, priced at $508 found 3 days ago
American Airlines
Thu, Dec 11 - Sun, Dec 14
DTW
Detroit
LSE
La Crosse
$514 Roundtrip, found 2 days ago
$514
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 11 from Detroit to La Crosse, returning Sun, Dec 14, priced at $514 found 2 days ago
American Airlines
Fri, Nov 21 - Tue, Nov 25
DTW
Detroit
LSE
La Crosse
$516 Roundtrip, found 3 days ago
$516
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Nov 21 from Detroit to La Crosse, returning Tue, Nov 25, priced at $516 found 3 days ago
American Airlines
Wed, Nov 26 - Sat, Nov 29
DTW
Detroit
LSE
La Crosse
$520 Roundtrip, found 3 days ago
$520
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 26 from Detroit to La Crosse, returning Sat, Nov 29, priced at $520 found 3 days ago
American Airlines
Mon, Nov 24 - Sat, Nov 29
DTW
Detroit
LSE
La Crosse
$521 Roundtrip, found 3 days ago
$521
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Nov 24 from Detroit to La Crosse, returning Sat, Nov 29, priced at $521 found 3 days ago

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE) cost?
Get a cheap one-way flight from $308 or cheap return flight from $468 from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE)?
December is the most affordable month to fly from DTW to LSE. Traveling during quieter months is often the key to finding better fares.
What is the cheapest airline that flies from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE)?
To find the cheapest airline flying from DTW to LSE, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE)?
There aren't any daily nonstop flights departing from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way in no time.
What day of the week has the most flights from DTW to LSE?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from DTW to LSE?
Consider booking with Delta Air Lines if you'd like to go straight from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE) without any delays. This airline has the strongest track record for punctuality, with an on-time score of 84%. Want to be notified if anything changes? You can keep an eye on your flight status using the Expedia App.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE)?
To avoid possible delays on the Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE) route, aim to fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE) last-minute?
Holding off until just before your trip to book a ticket from DTW to LSE generally means paying more. Although you may find some last-minute deals, they aren't always guaranteed. Keep your travel schedule open to maximize your chances of snagging a bargain.
Is it cheaper to book a DTW to LSE flight and hotel package?
Securing a DTW to LSE flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Choose from our impressive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to La Crosse Municipal Airport (LSE)?
If you booked your DTW to LSE flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Detroit Metropolitan Wayne County
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$468
Distance
415 mi

Book with confidence

Detroit to La Crosse Flights

The cheapest times to fly from Detroit to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to La Crosse are during the month of December. You can find some of the cheapest flights from Detroit to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to La Crosse

Sunday is one of the best days to book for cheap flights from Detroit to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $308 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Detroit to La Crosse Flights

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*Available to One Key members.