$130 Cheap Flights from Panama City (ECP) to Knoxville (TYS)

View $130 flight on Wed, Sep 24, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)

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Cheap Flights from Panama City to Knoxville (ECP-TYS)

Prices were available within the past 7 days and start at $130 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sat, Nov 22 - Tue, Nov 25
ECP
Panama City
TYS
Knoxville
$259 Roundtrip, just found
$259
Roundtrip
just found
Select Delta flight, departing Sat, Nov 22 from Panama City to Knoxville, returning Tue, Nov 25, priced at $259 just found
Delta
Mon, Nov 24 - Tue, Nov 25
ECP
Panama City
TYS
Knoxville
$283 Roundtrip, just found
$283
Roundtrip
just found
Select Delta flight, departing Mon, Nov 24 from Panama City to Knoxville, returning Tue, Nov 25, priced at $283 just found
American Airlines
Sat, Sep 20 - Mon, Sep 22
ECP
Panama City
TYS
Knoxville
$283 Roundtrip, found 2 days ago
$283
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Sep 20 from Panama City to Knoxville, returning Mon, Sep 22, priced at $283 found 2 days ago
Delta
Thu, Oct 23 - Sat, Oct 25
ECP
Panama City
TYS
Knoxville
$285 Roundtrip, found 6 days ago
$285
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Oct 23 from Panama City to Knoxville, returning Sat, Oct 25, priced at $285 found 6 days ago
Delta
Tue, Aug 12 - Sat, Sep 20
ECP
Panama City
TYS
Knoxville
$293 Roundtrip, found 5 hours ago
$293
Roundtrip
found 5 hours ago
Select Delta flight, departing Tue, Aug 12 from Panama City to Knoxville, returning Sat, Sep 20, priced at $293 found 5 hours ago
Delta
Sat, Aug 9 - Sat, Sep 20
ECP
Panama City
TYS
Knoxville
$294 Roundtrip, found 5 hours ago
$294
Roundtrip
found 5 hours ago
Select Delta flight, departing Sat, Aug 9 from Panama City to Knoxville, returning Sat, Sep 20, priced at $294 found 5 hours ago
Delta
Tue, Dec 23 - Tue, Jan 6
ECP
Panama City
TYS
Knoxville
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 23 from Panama City to Knoxville, returning Tue, Jan 6, priced at $299 found 1 day ago
Delta
Sun, Nov 23 - Fri, Nov 28
ECP
Panama City
TYS
Knoxville
$307 Roundtrip, just found
$307
Roundtrip
just found
Select Delta flight, departing Sun, Nov 23 from Panama City to Knoxville, returning Fri, Nov 28, priced at $307 just found
American Airlines
Fri, Sep 5 - Mon, Sep 8
ECP
Panama City
TYS
Knoxville
$312 Roundtrip, found 2 days ago
$312
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Sep 5 from Panama City to Knoxville, returning Mon, Sep 8, priced at $312 found 2 days ago
United
Wed, Aug 20 - Wed, Aug 27
ECP
Panama City
TYS
Knoxville
$575 Roundtrip, found 6 hours ago
$575
Roundtrip
found 6 hours ago
Select United flight, departing Wed, Aug 20 from Panama City to Knoxville, returning Wed, Aug 27, priced at $575 found 6 hours ago

Find the cheapest month to fly from Panama City (ECP) to Knoxville (TYS)

October is typically the cheapest month to fly

From $198 - $688 per traveler.

Graph displaying average flight prices per month

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $347
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $347
Flights from Panama City (ECP) to Knoxville (TYS)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
390 mi

Panama City to Knoxville Flights

The cheapest times to fly from Panama City to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Knoxville are during the month of November. You can find some of the cheapest flights from Panama City to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Knoxville

Sunday is one of the best days to book for cheap flights from Panama City to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $130 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $130 or cheap return flight from $259 from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
November is the most affordable month to fly from ECP to TYS. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from ECP to TYS. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from ECP to TYS?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on a range of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
Book a flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) last-minute?
Waiting until right before your break to book a ticket from ECP to TYS generally means paying more. While you may find some last-minute deals, they're not always guaranteed. Keep your travel schedule open for a better chance of scoring a bargain.
Is it cheaper to book an ECP to TYS flight and hotel package?
Opting for an ECP to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
If you booked your ECP to TYS flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.