
Popular airlines from Wilmington Intl. Airport (ILM) to McGhee Tyson Airport (TYS)
- American Airlines
American Airlines
- Delta
Delta
- United
United
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Cheap Flights from Wilmington to Knoxville (ILM-TYS)
Prices were available within the past 7 days and start at $100 for one-way flights and $214 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.










Find the cheapest month to fly from Wilmington (ILM) to Knoxville (TYS)
April is typically the cheapest month to fly
Graph displaying average flight prices per month
Alternative airports near Knoxville
Prices were available within the past 7 days. Prices and availability are subject to change.
Origin airport | Wilmington Intl. |
Destination airport | McGhee Tyson |
Airlines serving | American Airlines, Delta, United |
Roundtrip price | $198 |
Distance | 359 mi |
Wilmington to Knoxville Flights
The cheapest times to fly from Wilmington to Knoxville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Wilmington to Knoxville are during the month of August. You can find some of the cheapest flights from Wilmington to Knoxville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Wilmington to Knoxville
Sunday is one of the best days to book for cheap flights from Wilmington to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Wilmington to Knoxville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Wilmington to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $100 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Wilmington to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Wilmington to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Top Routes from Wilmington
- Wilmington to Chicago (ILM - ORD)
- Wilmington to Newark Liberty Intl. Airport (ILM - EWR)
- Wilmington to Phoenix (ILM - PHX)
- Wilmington to Los Angeles (ILM - LAX)
- Wilmington to Miami (ILM - MIA)
- Wilmington to Tampa (ILM - TPA)
- Wilmington to New York (ILM - LGA)
- Wilmington to Boston (ILM - BOS)
- Wilmington to Fort Lauderdale (ILM - FLL)
- Wilmington to Denver (ILM - DEN)
- Wilmington to New York (ILM - JFK)
- Wilmington to Seattle (ILM - SEA)
Top Routes to Knoxville
- Chicago to Knoxville (ORD - TYS)
- Newark Liberty Intl. Airport to Knoxville (EWR - TYS)
- Chicago to Knoxville (MDW - TYS)
- Los Angeles to Knoxville (LAX - TYS)
- Miami to Knoxville (MIA - TYS)
- Detroit to Knoxville (DTW - TYS)
- New York to Knoxville (LGA - TYS)
- Fort Lauderdale to Knoxville (FLL - TYS)
- Orange County to Knoxville (SNA - TYS)
- Boston to Knoxville (BOS - TYS)
- Denver to Knoxville (DEN - TYS)
- New York to Knoxville (JFK - TYS)
Top Routes from Wilmington
- American Airlines Wilmington to Chicago
- American Airlines Wilmington to Newark Liberty Intl. Airport
- Delta Wilmington to Phoenix
- Delta Wilmington to Los Angeles
- American Airlines Wilmington to Miami
- American Airlines Wilmington to Tampa
- Delta Wilmington to New York
- Delta Wilmington to Fort Lauderdale
- Delta Wilmington to Denver
- American Airlines Wilmington to New York
Top Routes to Knoxville
- American Airlines Chicago to Knoxville
- American Airlines Newark Liberty Intl. Airport to Knoxville
- Delta Chicago to Knoxville
- United Los Angeles to Knoxville
- American Airlines Miami to Knoxville
- Delta Detroit to Knoxville
- American Airlines New York to Knoxville
- Delta Fort Lauderdale to Knoxville
- American Airlines Orange County to Knoxville
- American Airlines Boston to Knoxville
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Jacksonville
Nearby Airports
- Albert J. Ellis Airport (OAJ)
- Grand Strand Airport (CRE)
- Myrtle Beach Intl. Airport (MYR)
- Fayetteville Regional Airport (FAY)
- Coastal Carolina Regional Airport (EWN)
- Pitt-Greenville Airport (PGV)
- Florence Regional Airport (FLO)
- Raleigh - Durham Intl. Airport (RDU)
- Charleston Intl. Airport (CHS)
- Dare County Regional Airport (MEO)
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