$149 Cheap Flights from Medellín (MDE) to Guayaquil (GYE)

View $149 flight on Sat, Feb 21, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)

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Cheap Flights from Medellín to Guayaquil (MDE-GYE)

Prices were available within the past 7 days and start at $149 for one-way flights and $294 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Nov 26 - Thu, Nov 27
MDE
Medellin
GYE
Guayaquil
$294 Roundtrip, found 2 days ago
$294
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Nov 26 from Medellin to Guayaquil, returning Thu, Nov 27, priced at $294 found 2 days ago
Copa
Wed, Nov 12 - Thu, Nov 13
MDE
Medellin
GYE
Guayaquil
$300 Roundtrip, found 3 days ago
$300
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Nov 12 from Medellin to Guayaquil, returning Thu, Nov 13, priced at $300 found 3 days ago
Copa
Tue, Nov 18 - Fri, Nov 21
MDE
Medellin
GYE
Guayaquil
$305 Roundtrip, found 3 days ago
$305
Roundtrip
found 3 days ago
Select Copa flight, departing Tue, Nov 18 from Medellin to Guayaquil, returning Fri, Nov 21, priced at $305 found 3 days ago
Copa
Tue, Nov 18 - Fri, Nov 21
MDE
Medellin
GYE
Guayaquil
$307 Roundtrip, found 3 days ago
$307
Roundtrip
found 3 days ago
Select Copa flight, departing Tue, Nov 18 from Medellin to Guayaquil, returning Fri, Nov 21, priced at $307 found 3 days ago
avianca
Fri, Nov 7 - Wed, Nov 12
MDE
Medellin
GYE
Guayaquil
$308 Roundtrip, found 5 days ago
$308
Roundtrip
found 5 days ago
Select avianca flight, departing Fri, Nov 7 from Medellin to Guayaquil, returning Wed, Nov 12, priced at $308 found 5 days ago
Copa
Wed, Mar 18 - Sat, Mar 21
MDE
Medellin
GYE
Guayaquil
$315 Roundtrip, found 2 days ago
$315
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Mar 18 from Medellin to Guayaquil, returning Sat, Mar 21, priced at $315 found 2 days ago
avianca
Fri, Nov 7 - Wed, Nov 12
MDE
Medellin
GYE
Guayaquil
$316 Roundtrip, found 5 days ago
$316
Roundtrip
found 5 days ago
Select avianca flight, departing Fri, Nov 7 from Medellin to Guayaquil, returning Wed, Nov 12, priced at $316 found 5 days ago
avianca
Fri, Nov 28 - Mon, Dec 1
MDE
Medellin
GYE
Guayaquil
$316 Roundtrip, found 3 days ago
$316
Roundtrip
found 3 days ago
Select avianca flight, departing Fri, Nov 28 from Medellin to Guayaquil, returning Mon, Dec 1, priced at $316 found 3 days ago
Copa
Wed, Nov 26 - Thu, Nov 27
MDE
Medellin
GYE
Guayaquil
$318 Roundtrip, found 2 days ago
$318
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Nov 26 from Medellin to Guayaquil, returning Thu, Nov 27, priced at $318 found 2 days ago
LATAM Airlines Group
Tue, Nov 11 - Mon, Nov 24
MDE
Medellin
GYE
Guayaquil
$400 Roundtrip, found 5 hours ago
$400
Roundtrip
found 5 hours ago
Select LATAM Airlines Group flight, departing Tue, Nov 11 from Medellin to Guayaquil, returning Mon, Nov 24, priced at $400 found 5 hours ago

Find the cheapest month to fly from Medellín (MDE) to Guayaquil (GYE)

February is typically the cheapest month to fly

From $236 - $475 per traveler.

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE) cost?
Lock in a cheap one-way flight from $149 or cheap return flight from $294 from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Flying in November is a good way to save, as it's the cheapest month for flights between MDE and GYE. You'll often find the lowest prices during off-peak months.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Board a direct flight with AVIANCA and go straight from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE).
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MDE to GYE flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
On average, you can pick from 3 direct flights per week from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE). For more options, consider a flight with a layover. Just enter your details on Expedia and then filter your search results to show one or more stops.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
More passengers fly between MDE and GYE at 6 PM than at any other time. Looking to skip the crowds? Consider flying outside peak hours and you could save on your ticket as well.
What day of the week has the most flights from MDE to GYE?
Travel on a Friday if you're after the best choice of flights from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE).
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
The earliest flight leaving from Jose Maria Cordova Intl. Airport (MDE) is at around 4:55PM UTC-5. Hop on this flight and you'll touch down at Jose Joaquin de Olmedo Intl. Airport (GYE) at approximately 6:45PM UTC-5. The overall travel time is 1h 50m.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
The average flight duration from MDE to GYE is 1 hour and 50 minutes, covering a total distance of 650 mi.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Select a flight from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE) that takes off before 3 PM to reduce the likelihood of delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Guayaquil from Jose Maria Cordova Intl. Airport (MDE)?
Browse your flight options from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE). This is the only Guayaquil airport you can land at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE) last-minute?
Last-minute fares from MDE to GYE are usually more expensive. For the best prices, start looking for flights early. That said, if you're flexible with your travel plans, it's possible to score a cheap fare right before your trip.
Is it cheaper to book a MDE to GYE flight and hotel package?
Securing a MDE to GYE flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our extensive range of stays and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
It's usually possible to cancel or reschedule your MDE to GYE flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

0
Origin airport
José María Córdova Intl.
Destination airport
Jose Joaquin de Olmedo Intl.
Airlines serving
Copa, LATAM Airlines Group, avianca
Roundtrip price
$294
Distance
651 mi

Book with confidence

Medellín to Guayaquil Flights

The cheapest times to fly from Medellín to Guayaquil

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Guayaquil are during the month of November. You can find some of the cheapest flights from Medellín to Guayaquil with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Guayaquil

Sunday is one of the best days to book for cheap flights from Medellín to Guayaquil: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Guayaquil

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Guayaquil in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Guayaquil flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Guayaquil airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Guayaquil Flights

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*Available to One Key members.