$101 Cheap Flights from Manchester (MHT) to Knoxville (TYS)

View $101 flight on Wed, Jan 7, 2026Opens in a new window

Popular airlines from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)

Cheap Flights from Manchester to Knoxville (MHT-TYS)

Prices were available within the past 7 days and start at $101 for one-way flights and $231 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jan 7 - Thu, Jan 8
MHT
Manchester
TYS
Knoxville
$231 Roundtrip, just found
$231
Roundtrip
just found
Select American Airlines flight, departing Wed, Jan 7 from Manchester to Knoxville, returning Thu, Jan 8, priced at $231 just found
United
Wed, Jan 7 - Thu, Jan 8
MHT
Manchester
TYS
Knoxville
$261 Roundtrip, just found
$261
Roundtrip
just found
Select United flight, departing Wed, Jan 7 from Manchester to Knoxville, returning Thu, Jan 8, priced at $261 just found
American Airlines
Wed, Jan 7 - Thu, Jan 8
MHT
Manchester
TYS
Knoxville
$266 Roundtrip, just found
$266
Roundtrip
just found
Select American Airlines flight, departing Wed, Jan 7 from Manchester to Knoxville, returning Thu, Jan 8, priced at $266 just found
United
Wed, Jan 7 - Thu, Jan 8
MHT
Manchester
TYS
Knoxville
$266 Roundtrip, just found
$266
Roundtrip
just found
Select United flight, departing Wed, Jan 7 from Manchester to Knoxville, returning Thu, Jan 8, priced at $266 just found
American Airlines
Tue, Feb 24 - Wed, Mar 4
MHT
Manchester
TYS
Knoxville
$273 Roundtrip, found 2 days ago
$273
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Feb 24 from Manchester to Knoxville, returning Wed, Mar 4, priced at $273 found 2 days ago
American Airlines
Mon, Jan 19 - Wed, Jan 21
MHT
Manchester
TYS
Knoxville
$293 Roundtrip, found 2 days ago
$293
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jan 19 from Manchester to Knoxville, returning Wed, Jan 21, priced at $293 found 2 days ago
American Airlines
Wed, Jan 7 - Thu, Jan 8
MHT
Manchester
TYS
Knoxville
$301 Roundtrip, just found
$301
Roundtrip
just found
Select American Airlines flight, departing Wed, Jan 7 from Manchester to Knoxville, returning Thu, Jan 8, priced at $301 just found
American Airlines
Sat, Feb 28 - Wed, Mar 4
MHT
Manchester
TYS
Knoxville
$304 Roundtrip, found 2 days ago
$304
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Feb 28 from Manchester to Knoxville, returning Wed, Mar 4, priced at $304 found 2 days ago
United
Fri, Jan 2 - Tue, Jan 6
MHT
Manchester
TYS
Knoxville
$309 Roundtrip, found 15 hours ago
$309
Roundtrip
found 15 hours ago
Select United flight, departing Fri, Jan 2 from Manchester to Knoxville, returning Tue, Jan 6, priced at $309 found 15 hours ago
Southwest Airlines
Sat, Apr 11 - Sat, Apr 18
MHT
Manchester
TYS
Knoxville
$353 Roundtrip, found 2 days ago
$353
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Sat, Apr 11 from Manchester to Knoxville, returning Sat, Apr 18, priced at $353 found 2 days ago

Find the cheapest month to fly from Manchester (MHT) to Knoxville (TYS)

August is typically the cheapest month to fly

From $248 - $492 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $497
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $497
Flights from Manchester (MHT) to Knoxville (TYS)
Origin airport
Manchester-Boston Regional
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Southwest Airlines, United
Roundtrip price
$230
Distance
830 mi

Manchester to Knoxville Flights

The cheapest times to fly from Manchester to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Manchester to Knoxville are during the month of January. You can find some of the cheapest flights from Manchester to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Manchester to Knoxville

Sunday is one of the best days to book for cheap flights from Manchester to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Manchester to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Manchester to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $101 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Manchester to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Manchester to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS) cost?
Snag a cheap one-way flight from $101 or cheap return flight from $231 from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from MHT to TYS is January, when there's less demand. Off-peak season is generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)?
To find the cheapest airline flying from MHT to TYS, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)?
There are no daily direct flights from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS). But you can opt for flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way in no time.
What day of the week has the most flights from MHT to TYS?
Usually you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* But this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)?
To land at McGhee Tyson Airport (TYS) without delays, book a flight that leaves Manchester-Boston Regional Airport (MHT) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS) last-minute?
Booking your flight from MHT to TYS just before your journey is usually more expensive. But if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a MHT to TYS flight and hotel package?
You'll typically save money by securing a MHT to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After choosing your ideal accommodations and flights, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Manchester-Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)?
Typically, you're able to cancel or reschedule your MHT to TYS flight. However, there may be additional charges, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, go to our Customer Service portal.

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*Available to One Key members.