A coastal cityscape with a long beach, clear turquoise waters, and high-rise buildings.

$123 Cheap Flights from Myrtle Beach (MYR) to Panama City (ECP)

View $123 flight on Sat, Oct 31, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Northwest Florida Beaches Intl. Airport (ECP)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Myrtle Beach to Panama City (MYR-ECP)

Prices were available within the past 7 days and start at $123 for one-way flights and $245 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 24 - Wed, Oct 28
MYR
Myrtle Beach
ECP
Panama City
$245 Roundtrip, found 5 hours ago
$245
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Wed, Oct 28, priced at $245 found 5 hours ago
Southwest Airlines
Sat, Oct 24 - Wed, Oct 28
MYR
Myrtle Beach
ECP
Panama City
$246 Roundtrip, found 5 hours ago
$246
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Wed, Oct 28, priced at $246 found 5 hours ago
Southwest Airlines
Sat, Oct 24 - Wed, Oct 28
MYR
Myrtle Beach
ECP
Panama City
$247 Roundtrip, found 5 hours ago
$247
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Wed, Oct 28, priced at $247 found 5 hours ago
Delta
Sat, Oct 31 - Thu, Nov 5
MYR
Myrtle Beach
ECP
Panama City
$262 Roundtrip, found 7 hours ago
$262
Roundtrip
found 7 hours ago
Select Delta flight, departing Sat, Oct 31 from Myrtle Beach to Panama City, returning Thu, Nov 5, priced at $262 found 7 hours ago
American Airlines
Sat, Oct 24 - Thu, Oct 29
MYR
Myrtle Beach
ECP
Panama City
$262 Roundtrip, found 5 hours ago
$262
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Thu, Oct 29, priced at $262 found 5 hours ago
Southwest Airlines
Sat, Oct 24 - Thu, Oct 29
MYR
Myrtle Beach
ECP
Panama City
$263 Roundtrip, found 5 hours ago
$263
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Thu, Oct 29, priced at $263 found 5 hours ago
Southwest Airlines
Sat, Oct 24 - Wed, Oct 28
MYR
Myrtle Beach
ECP
Panama City
$285 Roundtrip, found 5 hours ago
$285
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Wed, Oct 28, priced at $285 found 5 hours ago
Delta
Sat, Oct 31 - Thu, Nov 5
MYR
Myrtle Beach
ECP
Panama City
$297 Roundtrip, found 7 hours ago
$297
Roundtrip
found 7 hours ago
Select Delta flight, departing Sat, Oct 31 from Myrtle Beach to Panama City, returning Thu, Nov 5, priced at $297 found 7 hours ago
Southwest Airlines
Sat, Oct 24 - Thu, Oct 29
MYR
Myrtle Beach
ECP
Panama City
$302 Roundtrip, found 5 hours ago
$302
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Thu, Oct 29, priced at $302 found 5 hours ago
Southwest Airlines
Sat, Oct 24 - Wed, Oct 28
MYR
Myrtle Beach
ECP
Panama City
$311 Roundtrip, found 5 hours ago
$311
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Sat, Oct 24 from Myrtle Beach to Panama City, returning Wed, Oct 28, priced at $311 found 5 hours ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Panama City (ECP)

October is typically the cheapest month to fly

From $232 - $486 per traveler.

What you need to know for your flight from Myrtle Beach Intl. to Northwest Florida Beaches Intl.

North Myrtle Beach (MYR) to Panama City (ECP) at a glance

Travel from North Myrtle Beach (MYR) to Panama City (ECP) with a selection of airlines offering diverse options on this domestic short-haul route. Whether you're searching for cheap flights from Myrtle Beach or prefer a full-service experience, you can easily compare itineraries to find the best fit for your budget and schedule. Prepare to explore the iconic sights and neighborhoods of Panama City with key details on flights from Myrtle Beach International Airport (MYR) to Northwest Florida Beaches International Airport (ECP).

  • Fastest flight duration: around 2h 45m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 450 miles (725 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $110–$400, depending on seasonality and how far ahead you book

Flights from Myrtle Beach International Airport (MYR) to Northwest Florida Beaches International Airport (ECP)

According to recent traveler bookings, here are the top airlines favored for flights from North Myrtle Beach to Panama City, typically featuring one-stop services. Common layover points include Hartsfield-Jackson Atlanta International Airport (ATL) with an approximately 1 hour and 15-minute layover, Charlotte-Douglas International Airport (CLT) also around 1 hour and 15 minutes, and Nashville International Airport (BNA), offering similar layover times. This variety allows you to weigh options based on price, total travel time, and cabin class to craft the ideal itinerary.

  • Delta: As a full-service airline providing one-stop options, Delta holds about 51% of the departures for this route. One-way ticket prices generally fall between $125 and $380, with a flight duration of 2 hours and 45 minutes, leading to an overall travel time of around 4 hours, including layovers.
  • American Airlines: This full-service carrier, which also offers one-stop flights, makes up roughly 34% of the departures on this route. One-way fares typically range from $115 to $440, with an in-flight time of 2 hours and 45 minutes, resulting in a total journey time of approximately 4 hours, including layovers.
  • Southwest Airlines: Known as a low-cost carrier, Southwest provides one-stop services and accounts for about 15% of the flights on this route. One-way fares usually span from $110 to $285, featuring an in-flight duration of 2 hours and 45 minutes, with an overall travel time of around 4 hours, factoring in layovers.

Travelers flying from North Myrtle Beach to Panama City can opt for an upgrade, as Delta provides first-class service on this route.

Alternative route from North Myrtle Beach (MYR) to Panama City (ECP)

  • North Myrtle Beach to Fort Walton Beach (MYR-VPS): Northwest Florida Regional Airport (VPS) is located approximately 46 miles from Northwest Florida Beaches International Airport (ECP). On this route, one-way economy fares generally fall between $115 and $355, influenced by the season and timing of your booking. Most travelers find one-stop options, with common layover points being Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). Leading airlines operating on this route include Delta and American Airlines. Additionally, first-class service is offered on this journey.

How to find the best prices for flights from North Myrtle Beach (MYR) to Panama City (ECP)

Getting some of the best deals on flights from North Myrtle Beach to Panama City is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are typically found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Evening departures (6 PM to 12 AM) often offer lower prices, while morning flights (5 AM to 12 PM) are the most popular. Additionally, flying on Thursday usually provides cheaper options, even though Friday is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Northwest Florida Beaches International Airport from Myrtle Beach International Airport

Panama City welcomes travelers from North Myrtle Beach with a range of transport options based on price, convenience, and proximity. Here's how to reach Panama City efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Panama City, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Northwest Florida Beaches International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Northwest Florida Beaches International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) cost?
You can find cheap one-way flights from $123 and cheap return flights from $245 Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) with Expedia. One-way flights generally range between $159 and $633, and roundtrip flights usually range from $311 to $1069. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
October is the cheapest month to fly from Myrtle Beach, SC (MYR) to Panama City, FL (ECP), with average return fares around $241. This is about 42% lower than the average price throughout the year, as demand typically decreases after the summer season. Other economical months to consider are February and August.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Enter MYR to ECP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
To find a cheap flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
For flights from Myrtle Beach (MYR) to Panama City (ECP), October and February are the best months to fly, with average return flight prices around $241. October is less crowded, while February offers mild weather. These months provide a great combination of low prices and enjoyable travel conditions.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from MYR to ECP. To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The most popular departure times for flights from Myrtle Beach Intl. (MYR) to Northwest Florida Beaches Intl. (ECP) are from 6am to 9am. About 39% of passengers prefer this time window. Many major carriers, including American Airlines and Delta, offer flights during this window. This timing works well because it lets you enjoy a full day at the beach after arriving.
How long does it take to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
A flight from MYR to ECP with a layover takes around 5 hours 20 minutes, with the route covering approximately 464 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
First class seats are offered on the MYR to ECP route with Delta Air Lines and American Airlines.
How do I earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight with Expedia?
It's easy to earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from MYR (MYR)?
When traveling from MYR (MYR) to Panama City, you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP). Some flights may connect through major hubs like Charlotte-Douglas Intl. (CLT), Dallas-Fort Worth Intl. (DFW), Philadelphia Intl. (PHL) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) at the last minute?
Typically, booking a last minute flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package?
Securing a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
If you booked your Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines
Roundtrip price
$244
Distance
463 mi

Book with confidence

Myrtle Beach to Panama City Flights

The cheapest times to fly from Myrtle Beach to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Panama City are during the month of October. You can find some of the cheapest flights from Myrtle Beach to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Panama City

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $123 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia