$255 Cheap Flights from San Luis Obispo (SBP) to Knoxville (TYS)

View $255 flight on Wed, Dec 17, 2025Opens in a new window

Popular airlines from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from San Luis Obispo to Knoxville (SBP-TYS)

Prices were available within the past 7 days and start at $255 for one-way flights and $309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 10 - Sun, Dec 14
SBP
San Luis Obispo
TYS
Knoxville
$309 Roundtrip, found 9 hours ago
$309
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Dec 10 from San Luis Obispo to Knoxville, returning Sun, Dec 14, priced at $309 found 9 hours ago
American Airlines
Sat, Dec 13 - Wed, Dec 17
SBP
San Luis Obispo
TYS
Knoxville
$344 Roundtrip, found 5 days ago
$344
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Dec 13 from San Luis Obispo to Knoxville, returning Wed, Dec 17, priced at $344 found 5 days ago
United
Wed, Nov 12 - Sat, Nov 15
SBP
San Luis Obispo
TYS
Knoxville
$361 Roundtrip, found 6 days ago
$361
Roundtrip
found 6 days ago
Select United flight, departing Wed, Nov 12 from San Luis Obispo to Knoxville, returning Sat, Nov 15, priced at $361 found 6 days ago
United
Wed, Nov 12 - Sat, Nov 15
SBP
San Luis Obispo
TYS
Knoxville
$363 Roundtrip, found 6 days ago
$363
Roundtrip
found 6 days ago
Select United flight, departing Wed, Nov 12 from San Luis Obispo to Knoxville, returning Sat, Nov 15, priced at $363 found 6 days ago
American Airlines
Wed, Nov 5 - Mon, Nov 10
SBP
San Luis Obispo
TYS
Knoxville
$369 Roundtrip, found 15 hours ago
$369
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Nov 5 from San Luis Obispo to Knoxville, returning Mon, Nov 10, priced at $369 found 15 hours ago
American Airlines
Wed, Nov 5 - Mon, Nov 10
SBP
San Luis Obispo
TYS
Knoxville
$374 Roundtrip, found 15 hours ago
$374
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Nov 5 from San Luis Obispo to Knoxville, returning Mon, Nov 10, priced at $374 found 15 hours ago
American Airlines
Mon, Jan 5 - Fri, Jan 16
SBP
San Luis Obispo
TYS
Knoxville
$382 Roundtrip, found 10 hours ago
$382
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Mon, Jan 5 from San Luis Obispo to Knoxville, returning Fri, Jan 16, priced at $382 found 10 hours ago
American Airlines
Fri, Nov 14 - Mon, Nov 17
SBP
San Luis Obispo
TYS
Knoxville
$384 Roundtrip, found 2 days ago
$384
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Nov 14 from San Luis Obispo to Knoxville, returning Mon, Nov 17, priced at $384 found 2 days ago
American Airlines
Wed, Dec 17 - Tue, Dec 30
SBP
San Luis Obispo
TYS
Knoxville
$385 Roundtrip, found 1 day ago
$385
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 17 from San Luis Obispo to Knoxville, returning Tue, Dec 30, priced at $385 found 1 day ago
Alaska Airlines
Sat, Dec 6 - Tue, Dec 9
SBP
San Luis Obispo
TYS
Knoxville
$419 Roundtrip, found 22 hours ago
$419
Roundtrip
found 22 hours ago
Select Alaska Airlines flight, departing Sat, Dec 6 from San Luis Obispo to Knoxville, returning Tue, Dec 9, priced at $419 found 22 hours ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $369
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $369

Frequently asked questions

How much does a flight from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $255 or cheap return flight from $309 from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)?
December is the cheapest month to fly from SBP to TYS. Planning your trip for the off-season is often the key to finding a great deal.
What is the cheapest airline that flies from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)?
To find the cheapest airline flying from SBP to TYS, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)?
There aren't any daily nonstop flights departing from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from SBP to TYS?
Usually you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)?
To avoid possible delays on the San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS) route, fly before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS) last-minute?
Waiting until right before your break to book a ticket from SBP to TYS generally means paying more. While it's possible to find some last-minute offers, they aren't always guaranteed. Keep your travel schedule open for a better chance of scoring a bargain.
Is it cheaper to book a SBP to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a SBP to TYS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place will take the stress out of planning your trip. Just secure your flights and choose from our extensive range of hotels, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from San Luis Obispo County Regional Airport (SBP) to McGhee Tyson Airport (TYS)?
Usually, it's possible to reschedule or cancel your SBP to TYS flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
San Luis Obispo County Regional
Destination airport
McGhee Tyson
Airlines serving
Alaska Airlines, American Airlines, United
Roundtrip price
$308
Distance
2049 mi

Book with confidence

San Luis Obispo to Knoxville Flights

The cheapest times to fly from San Luis Obispo to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Luis Obispo to Knoxville are during the month of December. You can find some of the cheapest flights from San Luis Obispo to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Luis Obispo to Knoxville

Sunday is one of the best days to book for cheap flights from San Luis Obispo to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Luis Obispo to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Luis Obispo to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $255 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Luis Obispo to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Luis Obispo to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

San Luis Obispo to Knoxville Flights

Explore a world of travel with Expedia

*Available to One Key members.