$125 Cheap Flights from St. Louis (STL) to Knoxville (TYS)

View $125 flight on Mon, Nov 24, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to McGhee Tyson Airport (TYS)

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Cheap Flights from St. Louis to Knoxville (STL-TYS)

Prices were available within the past 7 days and start at $125 for one-way flights and $249 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Thu, Apr 30 - Sun, May 3
STL
St. Louis
TYS
Knoxville
$249 Roundtrip, found 2 hours ago
$249
Roundtrip
found 2 hours ago
Select Southwest Airlines flight, departing Thu, Apr 30 from St. Louis to Knoxville, returning Sun, May 3, priced at $249 found 2 hours ago
American Airlines
Fri, Dec 5 - Sun, Dec 7
STL
St. Louis
TYS
Knoxville
$249 Roundtrip, found 7 hours ago
$249
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Dec 5 from St. Louis to Knoxville, returning Sun, Dec 7, priced at $249 found 7 hours ago
Delta
Tue, Oct 28 - Fri, Oct 31
STL
St. Louis
TYS
Knoxville
$250 Roundtrip, found 23 hours ago
$250
Roundtrip
found 23 hours ago
Select Delta flight, departing Tue, Oct 28 from St. Louis to Knoxville, returning Fri, Oct 31, priced at $250 found 23 hours ago
Delta
Thu, Dec 25 - Wed, Dec 31
STL
St. Louis
TYS
Knoxville
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Dec 25 from St. Louis to Knoxville, returning Wed, Dec 31, priced at $251 found 6 days ago
United
Wed, Nov 12 - Sat, Nov 15
STL
St. Louis
TYS
Knoxville
$251 Roundtrip, found 1 day ago
$251
Roundtrip
found 1 day ago
Select United flight, departing Wed, Nov 12 from St. Louis to Knoxville, returning Sat, Nov 15, priced at $251 found 1 day ago
Delta
Wed, Nov 5 - Sat, Nov 8
STL
St. Louis
TYS
Knoxville
$253 Roundtrip, found 6 days ago
$253
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Nov 5 from St. Louis to Knoxville, returning Sat, Nov 8, priced at $253 found 6 days ago
American Airlines
Mon, Oct 20 - Sun, Oct 26
STL
St. Louis
TYS
Knoxville
$254 Roundtrip, just found
$254
Roundtrip
just found
Select American Airlines flight, departing Mon, Oct 20 from St. Louis to Knoxville, returning Sun, Oct 26, priced at $254 just found
Southwest Airlines
Sat, Mar 28 - Tue, Mar 31
STL
St. Louis
TYS
Knoxville
$254 Roundtrip, found 9 hours ago
$254
Roundtrip
found 9 hours ago
Select Southwest Airlines flight, departing Sat, Mar 28 from St. Louis to Knoxville, returning Tue, Mar 31, priced at $254 found 9 hours ago
American Airlines
Sat, Dec 6 - Tue, Dec 9
STL
St. Louis
TYS
Knoxville
$256 Roundtrip, found 6 days ago
$256
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Dec 6 from St. Louis to Knoxville, returning Tue, Dec 9, priced at $256 found 6 days ago
Frontier Airlines
Wed, Nov 12 - Tue, Nov 25
STL
St. Louis
TYS
Knoxville
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Nov 12 from St. Louis to Knoxville, returning Tue, Nov 25, priced at $264 found 1 day ago

Find the cheapest month to fly from St. Louis (STL) to Knoxville (TYS)

April is typically the cheapest month to fly

From $198 - $454 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $269
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $269

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $125 or cheap return flight from $249 from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from STL to TYS is April, when there's less demand. Off-peak months are often when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest STL to TYS flight.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
There are no daily direct flights from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from STL to TYS?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
To touch down at McGhee Tyson Airport (TYS) on schedule, select a flight that leaves from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS) last-minute?
Last-minute fares from STL to TYS are typically more expensive. To lock in the lowest rates, start searching for flights well ahead of time. That being said, if you're flexible with your travel dates, you may land a cheap ticket right before your journey.
Is it cheaper to book a STL to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a STL to TYS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place will take the hassle out of planning your trip. Just secure your flights and choose from our wide range of hotels, then customize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to McGhee Tyson Airport (TYS)?
If you reserved your STL to TYS flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$243
Distance
404 mi

Book with confidence

Book with confidence

St. Louis to Knoxville Flights

The cheapest times to fly from St. Louis to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Knoxville are during the month of April. You can find some of the cheapest flights from St. Louis to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Knoxville

Sunday is one of the best days to book for cheap flights from St. Louis to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $125 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Knoxville Flights

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Explore a world of travel with Expedia

*Available to One Key members.