$243 Cheap Flights from Tyler (TYR) to Knoxville (TYS)

View $243 flight on Sat, Nov 22, 2025Opens in a new window

Popular airlines from Tyler, TX (TYR-Pounds Regional) to McGhee Tyson Airport (TYS)

Cheap Flights from Tyler to Knoxville (TYR-TYS)

Prices were available within the past 7 days and start at $243 for one-way flights and $388 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 19 - Sat, Nov 22
TYR
Tyler
TYS
Knoxville
$388 Roundtrip, found 1 day ago
$388
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 19 from Tyler to Knoxville, returning Sat, Nov 22, priced at $388 found 1 day ago
American Airlines
Wed, Nov 19 - Sat, Nov 22
TYR
Tyler
TYS
Knoxville
$403 Roundtrip, found 1 day ago
$403
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 19 from Tyler to Knoxville, returning Sat, Nov 22, priced at $403 found 1 day ago
American Airlines
Thu, Nov 20 - Sat, Nov 22
TYR
Tyler
TYS
Knoxville
$419 Roundtrip, found 1 day ago
$419
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 20 from Tyler to Knoxville, returning Sat, Nov 22, priced at $419 found 1 day ago
American Airlines
Thu, Apr 30 - Tue, May 5
TYR
Tyler
TYS
Knoxville
$434 Roundtrip, found 6 days ago
$434
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 30 from Tyler to Knoxville, returning Tue, May 5, priced at $434 found 6 days ago
American Airlines
Sun, Oct 26 - Sat, Nov 15
TYR
Tyler
TYS
Knoxville
$440 Roundtrip, found 5 days ago
$440
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Oct 26 from Tyler to Knoxville, returning Sat, Nov 15, priced at $440 found 5 days ago
American Airlines
Sun, Oct 26 - Sat, Nov 15
TYR
Tyler
TYS
Knoxville
$446 Roundtrip, found 5 days ago
$446
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Oct 26 from Tyler to Knoxville, returning Sat, Nov 15, priced at $446 found 5 days ago
American Airlines
Thu, Nov 20 - Sun, Nov 23
TYR
Tyler
TYS
Knoxville
$450 Roundtrip, found 1 day ago
$450
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 20 from Tyler to Knoxville, returning Sun, Nov 23, priced at $450 found 1 day ago
American Airlines
Tue, Nov 18 - Wed, Dec 3
TYR
Tyler
TYS
Knoxville
$458 Roundtrip, found 1 day ago
$458
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 18 from Tyler to Knoxville, returning Wed, Dec 3, priced at $458 found 1 day ago
American Airlines
Wed, Nov 12 - Tue, Nov 25
TYR
Tyler
TYS
Knoxville
$464 Roundtrip, found 3 days ago
$464
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 12 from Tyler to Knoxville, returning Tue, Nov 25, priced at $464 found 3 days ago
American Airlines
Thu, Nov 20 - Mon, Nov 24
TYR
Tyler
TYS
Knoxville
$471 Roundtrip, found 1 day ago
$471
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 20 from Tyler to Knoxville, returning Mon, Nov 24, priced at $471 found 1 day ago

Frequently asked questions

How much does a flight from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS) cost?
Snag a cheap one-way flight from $243 or cheap return flight from $388 from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS)?
Traveling in November is a good way to save, as it's the cheapest month for flights between TYR and TYS. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from TYR to TYS, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS)?
You'll have to take a flight with a layover if you're traveling from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from TYR to TYS?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS) last-minute?
Waiting until right before your break to book your flight from TYR to TYS generally means paying more. While you may come across some last-minute offers, they're not always guaranteed. Allow some flexibility in your schedule to boost your chances of snagging a bargain.
Is it cheaper to book a TYR to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a TYR to TYS flight and hotel package with Expedia could result in significant savings. Better yet, managing everything in one place will take the hassle out of travel planning. Just secure your flights and select from our extensive range of hotels, then tailor your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Pounds Regional Airport (TYR) to McGhee Tyson Airport (TYS)?
If you reserved your TYR to TYS flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Travel information

Origin airport
Pounds Regional
Destination airport
McGhee Tyson
Airlines serving
American Airlines
Roundtrip price
$388
Distance
695 mi

Book with confidence

Tyler to Knoxville Flights

The cheapest times to fly from Tyler to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tyler to Knoxville are during the month of November. You can find some of the cheapest flights from Tyler to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tyler to Knoxville

Sunday is one of the best days to book for cheap flights from Tyler to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tyler to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tyler to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $243 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tyler to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tyler to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tyler to Knoxville Flights

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*Available to One Key members.