$449 Cheap Flights from Knoxville (TYS) to Florence (FLR)

View $449 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Florence Airport, Peretola (FLR)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Knoxville to Florence (TYS-FLR)

Prices were available within the past 7 days and start at $449 for one-way flights and $546 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Nov 28 - Thu, Dec 11
TYS
Knoxville
FLR
Florence
$546 Roundtrip, found 1 day ago
$546
Roundtrip
found 1 day ago
Select United flight, departing Fri, Nov 28 from Knoxville to Florence, returning Thu, Dec 11, priced at $546 found 1 day ago
Delta
Mon, Dec 1 - Mon, Dec 15
TYS
Knoxville
FLR
Florence
$547 Roundtrip, found 1 day ago
$547
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Dec 1 from Knoxville to Florence, returning Mon, Dec 15, priced at $547 found 1 day ago
United
Mon, Dec 8 - Wed, Dec 24
TYS
Knoxville
FLR
Florence
$550 Roundtrip, found 1 day ago
$550
Roundtrip
found 1 day ago
Select United flight, departing Mon, Dec 8 from Knoxville to Florence, returning Wed, Dec 24, priced at $550 found 1 day ago
Lufthansa
Wed, Dec 3 - Sun, Dec 7
TYS
Knoxville
FLR
Florence
$553 Roundtrip, found 4 hours ago
$553
Roundtrip
found 4 hours ago
Select Lufthansa flight, departing Wed, Dec 3 from Knoxville to Florence, returning Sun, Dec 7, priced at $553 found 4 hours ago
Delta
Thu, Dec 4 - Mon, Dec 15
TYS
Knoxville
FLR
Florence
$553 Roundtrip, found 1 day ago
$553
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 4 from Knoxville to Florence, returning Mon, Dec 15, priced at $553 found 1 day ago
Delta
Thu, Dec 4 - Wed, Dec 17
TYS
Knoxville
FLR
Florence
$559 Roundtrip, found 1 day ago
$559
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 4 from Knoxville to Florence, returning Wed, Dec 17, priced at $559 found 1 day ago
Lufthansa
Wed, Dec 3 - Sun, Dec 7
TYS
Knoxville
FLR
Florence
$565 Roundtrip, found 4 hours ago
$565
Roundtrip
found 4 hours ago
Select Lufthansa flight, departing Wed, Dec 3 from Knoxville to Florence, returning Sun, Dec 7, priced at $565 found 4 hours ago
Lufthansa
Wed, Dec 3 - Sun, Dec 7
TYS
Knoxville
FLR
Florence
$571 Roundtrip, found 4 hours ago
$571
Roundtrip
found 4 hours ago
Select Lufthansa flight, departing Wed, Dec 3 from Knoxville to Florence, returning Sun, Dec 7, priced at $571 found 4 hours ago
KLM
Sun, Jan 25 - Mon, Feb 9
TYS
Knoxville
FLR
Florence
$579 Roundtrip, found 1 day ago
$579
Roundtrip
found 1 day ago
Select KLM flight, departing Sun, Jan 25 from Knoxville to Florence, returning Mon, Feb 9, priced at $579 found 1 day ago
Scandinavian Airlines
Sat, Aug 22 - Fri, Sep 4
TYS
Knoxville
FLR
Florence
$597 Roundtrip, found 5 days ago
$597
Roundtrip
found 5 days ago
Select Scandinavian Airlines flight, departing Sat, Aug 22 from Knoxville to Florence, returning Fri, Sep 4, priced at $597 found 5 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Peretola FLR. Cheapest and Closest option available. Average driving time to city center is 14 minutes. Flights from $696
FLR
Peretola
CheapestClosest
Average driving time to city center14 min
Flights from $696

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Peretola Airport (FLR) cost?
Secure a cheap one-way flight from $449 or cheap return flight from $546 from McGhee Tyson Airport (TYS) to Peretola Airport (FLR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Peretola Airport (FLR)?
The cheapest month to fly from TYS to FLR is November, when there's less demand. Off-peak months are generally when you'll find lower airfares between these airports.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Peretola Airport (FLR)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll take you from TYS to FLR. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from McGhee Tyson Airport (TYS) to Peretola Airport (FLR)?
Nonstop flights from McGhee Tyson Airport (TYS) to Peretola Airport (FLR) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to FLR?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change based on a range of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Peretola Airport (FLR)?
To reach Peretola Airport (FLR) on schedule, select a flight that leaves from McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Peretola Airport (FLR) last-minute?
Booking your flight from TYS to FLR right before your trip is generally more expensive. However, if there's some wiggle room with your itinerary, you could bag a cheap last-minute fare.
Is it cheaper to book a TYS to FLR flight and hotel package?
You'll typically save money by securing a TYS to FLR flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your ideal flights and accommodations, consider other add-ons like car rentals, activities and tours.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Peretola Airport (FLR)?
In most instances, you can cancel or reschedule your TYS to FLR flight. However, additional charges may apply, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like more information, go to our Customer Service portal.

Travel information

Origin airport
McGhee Tyson
Destination airport
Peretola
Airlines serving
Air France, American Airlines, British Airways, Brussels Airlines, Delta, KLM, Lufthansa, Scandinavian Airlines, United
Roundtrip price
$545
Distance
4794 mi

Book with confidence

Knoxville to Florence Flights

The cheapest times to fly from Knoxville to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Florence are during the month of November. You can find some of the cheapest flights from Knoxville to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Florence

Sunday is one of the best days to book for cheap flights from Knoxville to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $449 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Florence Flights

Explore a world of travel with Expedia

*Available to One Key members.