Prices were available within the past 7 days and start at $69 for one-way flights and $139 for roundtrip, for the period specified. Prices and availability are subject to change.
Experience a range of airlines offering weekly flights from Knoxville (TYS) to Phoenix (PHX) on this domestic short-haul route. Whether you prefer full-service carriers or low-cost options, you can compare itineraries to find the best fit for your budget and schedule. As you plan your visit to explore Phoenix's iconic attractions and neighborhoods, be sure to check for the latest deals on flights from McGhee Tyson Airport (TYS) to Sky Harbor International Airport (PHX).
Fastest flight duration: around 6h 45m non-stop
Route distance: roughly 1,600 miles (2,570 km)
Flights per week: around 15+ flights with multiple daily departures on average
Typical fares (one-way): economy tickets often range from $115–$490, depending on seasonality and how far ahead you book
Flights from McGhee Tyson Airport (TYS) to Sky Harbor International Airport (PHX)
Recent traveler bookings reveal the top airlines favored for flights from Knoxville to Phoenix, particularly those with one-stop and multi-stop connections. Common layover points include Dallas-Fort Worth International Airport (DFW) with approximately a 1-hour and 15-minute layover, Hartsfield-Jackson Atlanta International Airport (ATL) at about 1 hour and 30 minutes, and Charlotte-Douglas International Airport (CLT) with a roughly 1-hour layover. These options allow travelers to mix and match price, total travel time, and cabin class to discover the ideal itinerary.
American Airlines: This full-service airline provides one-stop options, with one-way fares generally between $115 and $535. It represents about 51% of departures on this route, featuring an in-flight duration of 5 hours and 30 minutes, leading to an overall travel time of approximately 6 hours and 45 minutes, including layover time.
United: Another full-service option, United offers both non-stop and one-stop flights, with one-way prices typically ranging from $125 to $595. It covers around 20% of departures on this route, with a standard one-stop flight lasting 5 hours and 30 minutes, and a total journey time close to 6 hours and 45 minutes.
Delta: As a full-service carrier, Delta provides one-stop service with one-way fares usually between $130 and $535. It accounts for roughly 20% of departures on this route, offering an in-flight time of 5 hours and 30 minutes, and a total trip duration of around 6 hours and 45 minutes, including any layover.
Frontier Airlines: This low-cost airline features one-stop services, with one-way fares typically ranging from $115 to $325. Frontier accounts for about 7% of departures on this route, with an in-flight experience of 5 hours and 30 minutes and a total travel time of roughly 6 hours and 45 minutes, including layover.
Southwest Airlines: A low-cost option, Southwest provides one-stop service, with one-way fares generally falling between $210 and $645. This airline represents approximately 1% of departures on this route, featuring an in-flight time of 5 hours and 30 minutes and a total journey time of around 6 hours and 45 minutes, including layover time.
Travelers can enhance their journey from Knoxville to Phoenix by upgrading their flight. Top airlines include American Airlines, which features first-class service; United, offering both first class and premium economy; and Delta, providing both first class and premium economy options for a more comfortable experience.
Best time to fly from Knoxville (TYS) to Phoenix (PHX)
The most popular months for travelers flying from Knoxville to Phoenix are March, April, and October, when peak temperatures in Phoenix reach up to 77.7°F in October. If you prefer quieter travel, consider August, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 94.8°F. For better deals, August and September usually offer the lowest average one-way fares around $241. Flight availability peaks in October, with approximately 21 flights per week, making it easier to find convenient departure times.
Cheapest time to fly: August and September usually offer good deals with average one-way fares around $241, roughly 10% cheaper than the yearly average.
More budget-friendly months to fly: July and November typically offer average one-way fares of around $254.
Most flight options: October has the highest number of flights from Knoxville to Phoenix, with approximately 21 flights per week, giving you more flexibility in scheduling your trip.
Month
Temperature
Demand
Weekly Flights
Average one-way Fare
January
55.4°F (13.0°C)
Average
12
$291
February
58.6°F (14.8°C)
Average
15
$296
March
66.0°F (18.9°C)
High
15
$301
April
74.5°F (23.6°C)
High
15
$269
May
82.0°F (27.8°C)
Average
14
$262
June
92.3°F (33.5°C)
Low
13
$266
July
95.7°F (35.4°C)
Low
13
$250
August
94.8°F (34.9°C)
Low
12
$241
September
89.8°F (32.1°C)
Average
14
$241
October
77.7°F (25.4°C)
High
21
$277
November
65.5°F (18.6°C)
Average
16
$258
December
55.4°F (13.0°C)
Average
15
$281
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative routes from Knoxville (TYS) to Phoenix (PHX)
Knoxville to Scottsdale (TYS-SCF): Scottsdale Airport (SCF) lies approximately 14 miles from Sky Harbor International Airport (PHX), providing a convenient alternative for travelers heading to the area.
Knoxville to Mesa (TYS-AZA): Located about 22 miles from Sky Harbor International Airport (PHX), Phoenix - Mesa Gateway Airport (AZA) serves as another option for flights into the region.
Gatlinburg to Phoenix (GKT-PHX): Gatlinburg - Pigeon Forge Airport (GKT) is roughly 26 miles from McGhee Tyson Airport (TYS), making it a viable choice for those flying to Phoenix.
How to find the best prices for flights from Knoxville (TYS) to Phoenix (PHX)
Getting some of the best deals on flights from Knoxville to Phoenix is all about timing and flexibility. Here are some key tips to help you save:
Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which aligns with when most travelers make their reservations. Departures in the afternoon (12pm-6pm) often come with lower prices, while morning flights (5am-12pm) are the most popular. Additionally, flying on Thursday typically offers cheaper rates, though Saturday remains the busiest travel day.
Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at Sky Harbor International Airport from McGhee Tyson Airport
Phoenix welcomes travelers from Knoxville with a range of transport options based on price, convenience, and proximity. For departures, McGhee Tyson Airport is roughly a 20-minute drive (covering about 15 miles) from central Knoxville. Here's how to reach Phoenix efficiently:
Hotel transfer: Transfers offer a convenient way to reach your hotel in Phoenix, with private rides that can be arranged in advance.
Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
Public transportation: From Sky Harbor International Airport, Terminal 3 Station, a metro station, is located about 0.1 miles away on foot, while Phoenix Airport Bus Stop, a bus station, is situated approximately 0.2 miles away on foot, providing convenient access to public transport options for travelers.
Knoxville to Phoenix Flights
The cheapest times to fly from Knoxville to Phoenix
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Phoenix are during the month of January. You can find some of the cheapest flights from Knoxville to Phoenix with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Knoxville to Phoenix
Sunday is one of the best days to book for cheap flights from Knoxville to Phoenix: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Knoxville to Phoenix
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Phoenix in 2026. You can also book with separate airlines for your outbound and return journeys, from $69 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Phoenix flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Phoenix airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) cost?
You can find cheap one-way flights from $69 and cheap return flights $139 Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) with Expedia. One-way flights typically cost between $171 and $1280, and return flights often range between $380 and $1380. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
The cheapest month to fly from TYS to PHX is January when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
Enter TYS to PHX and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
The earliest flight from McGhee Tyson (TYS) to Sky Harbor International (PHX) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is active in March and April, allowing you to maximize your time in Phoenix. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
The most popular departure times for flights from Knoxville (TYS) to Phoenix (PHX) are in the early morning, from 6am to 9am. About 26% of passengers prefer this time window. Many major carriers, including American Airlines and United Airlines, offer flights during this window. This timing works well because it helps you arrive in Phoenix with a full day ahead of you.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
A flight from TYS to PHX with a layover takes around 6 hours 50 minutes, with the route covering approximately 1,596 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
First class seats are offered on the TYS to PHX route. First class cabins are available on:
American Airlines
United Airlines
Delta Air Lines
How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Phoenix from McGhee Tyson (TYS)?
From McGhee Tyson (TYS), you can fly into Sky Harbor Intl. (PHX) to reach Phoenix. Some flights may connect through major hubs like Dallas-Fort Worth Intl. (DFW), O'Hare Intl. (ORD), Charlotte-Douglas Intl. (CLT) before reaching Phoenix. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) Phoenix Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to Phoenix, AZ (PHX-Sky Harbor Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport
McGhee Tyson Airport
Destination airport
Phoenix Sky Harbor Intl. Airport
Distance
1,596 miles away
Airlines serving
Allegiant Air, United, American Airlines, Delta, Southwest Airlines, Alaska Airlines