
Santee Vacations from $607
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Your Santee Vacation
Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!
The Latest Santee vacation packages
Price found within the past 48 hours. Click for updated prices.





Staybridge Suites Columbia by IHG
Downtown Columbia
Price was $687, price is now $632 per person
$632
per person
Jan 26 - Jan 29
found 10 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Columbia (CAE)
9.2/10 Wonderful! (1,006 reviews)
Property was clean. Only negative was trying to get into and out of the property during peak hours
Reviewed on Oct 29, 2026
Stay near popular Santee attractions
Santee Hotel Deals

Tru By Hilton Santee
263 Britain St. and 273 Britain St. Santee SC
$103 nightly
The price is $114 total per night from Nov 29 to Nov 30
$114 total
Nov 29 - Nov 30
Total with taxes and fees
9.2/10 Wonderful! (1,010 reviews)
"Great property. Rooms were nice with NO CARPET which was great! Very good breakfast! Very clean and welcoming with a pool and fitness room and right of I-95!"
Reviewed on Nov 2, 2026

Baymont by Wyndham Santee
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Nov 5 to Nov 6
$89 total
Nov 5 - Nov 6
Total with taxes and fees
8/10 Very Good! (1,507 reviews)
"Great place to stop while heading south"
Reviewed on Nov 3, 2026

Fairfield Inn & Suites by Marriott Santee
9074 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $154 total per night from Nov 11 to Nov 12
$154 total
Nov 11 - Nov 12
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santee Vacation Packages
Santee Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 940 |
Max Temp Winter | 55ºF |
Max Temp Summer | 90ºF |
Top Sights | Santee State Park, Santee Cooper Country Club and Santee National Golf Club |
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