Santee Vacations from $607

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Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites Columbia Downtown - The Vista by IHG
Hyatt Place Columbia/Downtown/The Vista
SpringHill Suites by Marriott Columbia Downtown/The Vista
Candlewood Suites, Columbia/Ft. Jackson by IHG
Staybridge Suites Columbia by IHG
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Stay near popular Santee attractions

Santee Hotel Deals

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
$103 nightly
The price is $114 total per night from Nov 29 to Nov 30
$114 total
Nov 29 - Nov 30
Total with taxes and fees
9.2/10 Wonderful! (1,010 reviews)
"Great property. Rooms were nice with NO CARPET which was great! Very good breakfast! Very clean and welcoming with a pool and fitness room and right of I-95!"

Reviewed on Nov 2, 2026

Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Nov 5 to Nov 6
$89 total
Nov 5 - Nov 6
Total with taxes and fees
8/10 Very Good! (1,507 reviews)
"Great place to stop while heading south"

Reviewed on Nov 3, 2026

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $154 total per night from Nov 11 to Nov 12
$154 total
Nov 11 - Nov 12
Total with taxes and fees
Fairfield Inn & Suites by Marriott Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santee Vacation Packages

Santee Essential Information

Language
English
Currency
U.S dollars
Population
940
Max Temp Winter
55ºF
Max Temp Summer
90ºF
Top Sights
Santee State Park, Santee Cooper Country Club and Santee National Golf Club

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Frequently asked questions

What's included in a Santee vacation package?
A Santee vacation package lets you combine round-trip flights, hotel stays, and a rental car, offering a convenient way to explore this outdoor destination. Many hotels in Santee include free breakfast, providing a relaxed start to your day. For added convenience, some properties also offer airport shuttle service to and from Charleston, SC (CHS-Charleston Intl.) Airport, located about 48 miles away.

Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Santee vacation package?
When you bundle, you can save up to 30%*. To save money on a Santee package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What's the best vacation package for Santee?
For families seeking the best vacation packages in Santee, a Santee vacation package built around a stay at Fairfield Inn & Suites by Marriott Santee is a strong choice. This property, rated 9.4 out of 10, features family rooms and an outdoor pool, making it comfortable for all ages. Travelers frequently praise its great pool and extremely polite staff.

Couples looking for a romantic Santee vacation package might consider a stay at Holiday Inn Santee by IHG. Rated 8.2 out of 10, this hotel offers a bar/lounge and an indoor pool, providing relaxing spaces for unwinding. Travelers often highlight the highly appreciated staff and the hotel's well-kept overall condition.

For those seeking value, a Santee vacation package with a stay at Travelodge by Wyndham Santee is a budget-friendly option, costing around $70 per night. This hotel offers free breakfast and free WiFi, and travelers appreciate its comfy rooms and good value.

*Package availability and prices may change depending on dates and demand.
Is Santee a good choice for a family vacation package?
Santee is a strong choice for family vacation packages, offering a relaxed outdoor setting with family-friendly accommodations and activities.

Properties like Fairfield Inn & Suites by Marriott Santee, rated 9.4 out of 10 by travelers, provide amenities such as family rooms, an outdoor pool, and free breakfast, making it a comfortable base for families. Guests often praise the generously sized rooms and great breakfast.

For outdoor fun, families can visit Santee State Park, located about 3 miles from central Santee, or explore the natural landscapes and wildlife at Santee National Wildlife Refuge, about 4 miles away.

These options help create a memorable Santee vacation package for all ages.
What are the top things to do in Santee?
Santee, an outdoor and nature destination, offers a variety of activities centered around its natural beauty and recreational opportunities:

Your Santee vacation can be customized around these activities. Browse and book things to do in Santee on Expedia.
Do you need to rent a car in Santee, or is public transport enough?
For a Santee vacation package, renting a car is highly recommended to fully explore this outdoor and nature destination.

Santee's attractions, such as Santee State Park (about 3 miles from central Santee) and Santee National Wildlife Refuge (about 4 miles away), are spread out. A car provides the flexibility to visit these scenic spots and other recreational areas at your own pace.

Charleston International Airport (CHS) is about 48 miles from Santee, making a rental car or pre-arranged shuttle service practical for airport transfers. While some hotels are walkable to central Santee, a car is essential for maximizing your Santee vacation packages with flights and exploring the wider region.
Are Santee vacation package hotels conveniently located?
Santee vacation package hotels are generally well-located, with many properties offering convenient access to the town's central area.

For instance, Tru By Hilton Santee and Holiday Inn Santee by IHG are both about a 5-minute walk from central Santee. Other options like Hampton Inn Santee-I-95 and Best Western Plus Santee Inn are about a 10-minute walk away.

Staying in central Santee places you within easy reach of local amenities and attractions, making it simple to enjoy your Santee vacation package.
Can I change or cancel my Santee vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Santee vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Santee vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Santee?
To find last-minute vacation packages to Santee, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Santee vacation packages?
Free cancellation on a Santee vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Santee vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Santee getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Santee vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.