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Find 4 Star Hotels in Santee, SC

Check availability on Santee 4 Star Hotels

Tonight
Oct 16 - Oct 17
Tomorrow
Oct 17 - Oct 18
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Santee 4-star hotels

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.
A hotel room with two beds, a desk, and a large window with a view.
A modern lobby with a blue sofa, teal chairs, and a wooden table.
A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

1. Tru By Hilton Santee

Tru By Hilton Santee
Santee
United States
Connor
$101 nightly
$112 total
Nov 1 - Nov 2
Total with taxes and fees
Tru By Hilton Santee
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.
A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
United States
Cindy
$80 nightly
$89 total
Oct 18 - Oct 19
Total with taxes and fees
Baymont by Wyndham Santee
A patio area with wicker furniture, a stone fire pit, and outdoor seating.
A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.
A reception desk with a wooden panel wall and a circular decorative piece above it.
A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

3. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
Santee
United States
Victor
$139 nightly
$154 total
Oct 25 - Oct 26
Total with taxes and fees
Fairfield Inn & Suites by Marriott Santee
A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.
A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.
A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.
A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

4. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
Santee
United States
santa
$101 nightly
$112 total
Nov 8 - Nov 9
Total with taxes and fees
Comfort Inn & Suites Santee
A hotel entrance with a sign reading "Best Western PLISS."
A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.
A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

5. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
United States
Johnny
$139 nightly
$155 total
Oct 27 - Oct 28
Total with taxes and fees
Best Western Plus Santee Inn
A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.
A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.
A gym with treadmills, weight machines, and a wall of dumbbells.
A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

6. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
Santee
United States
sandra
$119 nightly
$132 total
Nov 3 - Nov 4
Total with taxes and fees
Hampton Inn Santee-I-95
A water park with a pool, slides, and umbrellas.
A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.
A reception desk with a wooden panel backdrop and a neon sign.
A modern lounge area with seating, tables, and a fireplace.

7. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
Santee
United States
Stacey
$107 nightly
$119 total
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn Santee by IHG
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.
A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.
A living room with a brown sofa set, a wooden coffee table, and a chandelier.
A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

8. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
Santee
United States
Doug
$59 nightly
$65 total
Nov 8 - Nov 9
Total with taxes and fees
Quality Inn & Suites Santee I-95
A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.
A kitchen with a countertop, cabinets, a microwave, and a sink.
A motel with a brick facade, a covered entrance, and a satellite dish.
A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

9. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
Santee
United States
Robert
$64 nightly
$71 total
Nov 16 - Nov 17
Total with taxes and fees
Travelodge by Wyndham Santee
Lobby
A gym with treadmills, an elliptical, dumbbells, and a bench.
A conference room with round tables, black chairs, and white tablecloths.
A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

10. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
United States
Stevenson
$79 nightly
$88 total
Oct 19 - Oct 20
Total with taxes and fees
Ramada by Wyndham Santee I-95
A two-story building with a flat roof and a central entrance.
A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.
A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.
A hotel room with a large bed, a desk, a television, and a door.

11. Red Roof Inn Santee

Red Roof Inn Santee
Santee
United States
Tiffany
$63 nightly
$70 total
Oct 20 - Oct 21
Total with taxes and fees
Red Roof Inn Santee
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A reception area with a marble counter, a television, and a logo for 'Superstart breakfast'.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

12. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
United States
William
$64 nightly
$71 total
Oct 25 - Oct 26
Total with taxes and fees
Super 8 by Wyndham Santee/I-95
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A reception area with a counter, framed pictures, and a clock on the wall.
A bathroom with a sink, mirror, and a shower area.
A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

13. Econo Lodge Santee

Econo Lodge Santee
Santee
United States
Arthur
$68 nightly
$75 total
Nov 8 - Nov 9
Total with taxes and fees
Econo Lodge Santee
A modern living room with a dining area, large windows, and a flat-screen TV.
A modern kitchen with a marble countertop, a dining area with a sofa and chairs, and large windows with blinds.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and greenery.
A lakeside view with a grassy area, a concrete path, and trees.

14. Waterfront Condo on Lake Marion

Waterfront Condo on Lake Marion
Santee
United States
Tuwanna G.
Waterfront Condo on Lake Marion
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Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

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A tree with Spanish moss and autumn leaves in a body of water.

Top Santee Hotel Reviews

Find out more about Santee

Santee Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santee, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santee 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santee. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santee, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santee hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Santee?
Expedia can help you easily find the perfect 4-star hotel for your vacation in Santee. Use our handy filter tool to fine-tune your search by things like budget, amenities and hotel star rating and get access to awesome deals in a couple of clicks.
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What's the difference between 5-star and 4-star hotels in Santee?
Treat yourself to luxury living during your Santee escape by choosing a 4-star hotel. As well as featuring upscale surroundings, these properties are usually filled with amenities such as large beds, bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more indulgent and unforgettable one. Round-the-clock concierge assistance, elegant décor and world-class dining are a few of the first-rate conveniences and services you'll likely have access to.
Does Santee have any 4-star all-inclusive resorts?
Enjoy a worry-free vacation experience where almost everything is included in one upfront price by using our "All inclusive" filter. Budgeting is easy when your room, food and many activities are already taken care of. Eager for more options? Check out the offers on Expedia's standard 4-star stays in and around Santee too.

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