Find 4 Star Hotels in Santee, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee 4 Star Hotels

Tonight
Jan 7 - Jan 8
Tomorrow
Jan 8 - Jan 9
This weekend
Jan 9 - Jan 11
Next weekend
Jan 16 - Jan 18

Our top choices for Santee 4-star hotels

Exterior
Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion
4.0 star property
Santee
9.2 out of 10, Wonderful, (21)
"Excellent "
United States
John
Wyndham Vacation Resorts Lake Marion
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

10/10 Excellent
"Excellent "
John 2-night trip
Posted 1 month ago
Wyndham Vacation Resorts Lake Marion

Find out more about Santee

Santee Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santee, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santee 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santee. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santee, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santee hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Santee?
Expedia can help you easily find the perfect 4-star hotel for your vacation in Santee. Use our handy filter tool to fine-tune your search by things like budget, amenities and hotel star rating and get access to awesome deals in a couple of clicks.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Santee?
Treat yourself to luxury living during your Santee escape by choosing a 4-star hotel. As well as featuring upscale surroundings, these properties are usually filled with amenities such as large beds, bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more indulgent and unforgettable one. Round-the-clock concierge assistance, elegant décor and world-class dining are a few of the first-rate conveniences and services you'll likely have access to.
Does Santee have any 4-star all-inclusive resorts?
Enjoy a worry-free vacation experience where almost everything is included in one upfront price by using our "All inclusive" filter. Budgeting is easy when your room, food and many activities are already taken care of. Eager for more options? Check out the offers on Expedia's standard 4-star stays in and around Santee too.

Explore a world of travel with Expedia