Title: The Best 4 Star Hotels in Murphysboro, IL from $178 | Expedia.com

[Murphysboro Travel Guide](https://expedia.com/Murphysboro.dx55857)[Hotels in Murphysboro](https://expedia.com/Murphysboro-Hotels.d55857.Travel-Guide-Hotels)[Vacation Rentals in Murphysboro](https://expedia.com/Murphysboro-Vacation-Rentals.d55857.Travel-Guide-VacationRentals)[Flights to Murphysboro](https://expedia.com/Cheap-Flights-To-Murphysboro.d55857.Travel-Guide-Flights)[Car Rentals in Murphysboro](https://expedia.com/Car-Rentals-In-Murphysboro.d55857.Car-Rental-Guide)[Murphysboro Vacation Packages](https://expedia.com/Murphysboro.d55857.Destination-Travel-Guides)

![Lake Murphysboro State Park which includes autumn leaves, picnicing and forests](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Southernmost Illinois Tourism Bureau

![](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Murphysboro 4 Star Hotels

Tonight

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 7 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-02-07&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Murphysboro 4-star hotels

![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/8fcd4708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a0fca68c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/2902012c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/84958281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walker's Bluff Casino Resort

[](https://www.expedia.com/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information)

Carterville

9.4/10

Exceptional

(415 reviews)

"Our room was clean, and very spacious! the establishment was very nice! We had reservations at Ruthie’s and it was amazing like always "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy

$160 nightly

$178 total

Feb 8 - Feb 9

Total with taxes and fees

[](https://www.expedia.com/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information)

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## Learn more about Murphysboro

Barbecue enthusiasts flock to the Apple Festival and award-winning 17th Street BBQ for Southern Illinois' most celebrated smoked meats. Outdoor adventurers can explore nearby Kinkaid Lake's fishing spots or take a short drive to Shawnee National Forest's hiking trails.

[See all hotels in Murphysboro](https://www.expedia.com/Hotel-Search?startDate=2026-02-21&endDate=2026-02-22&adults=2&regionId=55857)

![Lake Murphysboro State Park which includes autumn leaves, picnicing and forests](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

Photo by Southernmost Illinois Tourism Bureau

## Top Murphysboro Hotel Reviews

## Find out more about Murphysboro

## Murphysboro Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Murphysboro, Illinois are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Murphysboro 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Murphysboro. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Murphysboro, Illinois, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Murphysboro hotels offer everything your heart desires.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Murphysboro?

> - Search for the lowest price from $178

### What's the difference between 5-star and 4-star hotels in Murphysboro?

### Does Murphysboro have any 4-star all-inclusive resorts?

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- [General John A. Logan Museum ](https://www.expedia.com/General-John-A-Logan-Museum-Murphysboro.d6186673.Vacation-Attraction)
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