Title: The Best 5 Star Hotels in Cayce, SC from $164 | Expedia.com

[Cayce Travel Guide](https://expedia.com/Cayce.dx55624)[Hotels in Cayce](https://expedia.com/Cayce-Hotels.d55624.Travel-Guide-Hotels)[Vacation Rentals in Cayce](https://expedia.com/Cayce-Vacation-Rentals.d55624.Travel-Guide-VacationRentals)[Flights to Cayce](https://expedia.com/Cheap-Flights-To-Cayce.d55624.Travel-Guide-Flights)[Car Rentals in Cayce](https://expedia.com/Car-Rentals-In-Cayce.d55624.Car-Rental-Guide)[Cayce Vacation Packages](https://expedia.com/Cayce.d55624.Destination-Travel-Guides)

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## Check availability on Cayce 5 Star Hotels

Tonight

[Mar 9 - Mar 10](https://www.expedia.com/Hotel-Search?regionId=55624&startDate=2026-03-09&endDate=2026-03-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=55624&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=55624&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=55624&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Cayce.

![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Graduate by Hilton Columbia SC

1619 Pendleton Street Columbia SC

$147 nightly

$164 total

Mar 22 - Mar 23

Total with taxes and fees

9.4/10 Exceptional! (1,006 reviews)

[](https://expedia.com/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information)

![Chesnut Cottage Inn](https://images.trvl-media.com/lodging/110000000/109950000/109942900/109942803/a69caa6b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Chesnut Cottage Inn

1718 Hampton St Columbia SC

$183 nightly

$205 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://expedia.com/Columbia-Hotels-Chesnut-Cottage-Inn-Bed-Breakfast.h109942803.Hotel-Information)

![Columbia Vacation Rental - Walk to Uofsc Campus!](https://images.trvl-media.com/lodging/104000000/103320000/103319600/103319588/d831ac81_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Columbia Vacation Rental - Walk to Uofsc Campus!

 Columbia SC

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=103319588&PinnedHotelID=103319588&HadPinnedHotel=true&regionId=55624)

[](https://expedia.com/Columbia-Hotels-Columbia-Vacation-Rental-Walk-To-Uofsc-Campus.h103319588.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Cayce.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&regionId=55624&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Cayce

Explore the Cayce Riverwalk Park's scenic trails where locals jog alongside the Congaree River with views of wildlife. History buffs can visit the Cayce Historical Museum to see artifacts from 12,000 years of local settlement and colonial trading posts.

[See all hotels in Cayce](https://www.expedia.com/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24&adults=2&regionId=55624)

![Downtown Columbia South Carolina Skyline SC Aerial Panorama](https://images.trvl-media.com/place/55624/70870330-6ac6-42f8-9237-8283f57a8f7b.jpg?impolicy=fcrop&w=900&h=459&p=1&q=high)

## Top Cayce Hotel Reviews

## Find out more about Cayce

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming sabbatical. There's no reason to delay a getaway to Cayce any longer. You'll join the multitudes of vacationers who have made Cayce so fashionable in the last year. The hotels in Cayce also offer great customer service, averaging 3.6 in our ranking system, setting you up for a truly relaxing getaway. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Cayce and get ready to enjoy the getaway of a lifetime.

### Book the Best Cayce 5-Star Hotels

You can expect high quality from your hotel. Spa treatments, delicious meals, and personalized service are all waiting for you. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in Cayce offer great customer service, averaging 3.6 in our ranking system, so you know you're in good hands. What creature comforts do you want in your lodging? A rejuvenating facial treatment to help your cares fall away? A concierge to help you plan every detail of your day? Plush carpeting, delectable chocolate desserts, and even spectacular views...these hotels have it all. 

You won't sleep and order room service the entire time, though. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Cayce are the perfect place to rest up after a busy day. Ready to learn more? Read the review section and see what previous visitors have said. You're sure to find exactly what you're looking for! 

### Make Your Escape

The results are in, and Cayce 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. It's time to indulge yourself -- Expedia can help you land a great deal on accommodation. Choose one of our Cayce 5-star hotels today and dive into in luxe surroundings when you're ready.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Cayce?

> - Search for the lowest price per night from $164

### What makes a hotel 5 stars in Cayce?

### Are there any 5-star all-inclusive resorts in Cayce?

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