Title: The Best 5 Star Hotels in Salem, SC from $179 | Expedia.com [Salem Travel Guide](https://expedia.com/Salem.dx63870)[Hotels in Salem](https://expedia.com/Salem-Hotels.d63870.Travel-Guide-Hotels)[Vacation Rentals in Salem](https://expedia.com/Salem-Vacation-Rentals.d63870.Travel-Guide-VacationRentals)[Flights to Salem](https://expedia.com/Cheap-Flights-To-Salem.d63870.Travel-Guide-Flights)[Car Rentals in Salem](https://expedia.com/Car-Rentals-In-Salem.d63870.Car-Rental-Guide)[Salem Vacation Packages](https://expedia.com/Salem.d63870.Destination-Travel-Guides) ![Couple kayaking in remote lake](https://images.trvl-media.com/place/63870/969aae59-3d24-4cff-9457-a4cda46929a4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/63870/969aae59-3d24-4cff-9457-a4cda46929a4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Salem 5 Star Hotels Tonight [Mar 24 - Mar 25](https://www.expedia.com/Hotel-Search?regionId=63870&startDate=2026-03-24&endDate=2026-03-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 25 - Mar 26](https://www.expedia.com/Hotel-Search?regionId=63870&startDate=2026-03-25&endDate=2026-03-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=63870&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=63870&startDate=2026-04-03&endDate=2026-04-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Salem-Hotels.s50-0-d63870.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Salem-Hotels.s50-0-d63870.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Salem. ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Shepherd Hotel Downtown Clemson 110 Sloan St Clemson SC $218 nightly $242 total Apr 6 - Apr 7 Total with taxes and fees 9.8/10 Exceptional! (773 reviews) [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![The Abernathy of Clemson](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Abernathy of Clemson 157 Old Greenville Hwy Clemson SC $161 nightly $179 total Apr 21 - Apr 22 Total with taxes and fees 9.6/10 Exceptional! (579 reviews) [](https://expedia.com/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Liberty Hall Bed and Breakfast](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7ccc39b2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Liberty Hall Bed and Breakfast 621 S Mechanic St Pendleton SC $170 nightly $189 total Mar 31 - Apr 1 Total with taxes and fees 10/10 Exceptional! (85 reviews) [](https://expedia.com/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) Still don't see what you're looking for? [See all properties in Salem.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=63870&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Salem Nestled along Lake Keowee, this small town offers peaceful fishing spots and scenic hiking trails in Devils Fork State Park. Rent a pontoon boat to explore the lake's hidden coves or visit nearby Oconee State Park for waterfall views. [See all hotels in Salem](https://www.expedia.com/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08&adults=2®ionId=63870) ![Couple kayaking in remote lake](https://images.trvl-media.com/place/63870/969aae59-3d24-4cff-9457-a4cda46929a4.jpg?impolicy=fcrop&w=900&h=597&p=1&q=high) ## Top Salem Hotel Reviews ## Find out more about Salem Why not ask for the best on your excursion to Salem? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Salem so popular in the last year. There's no reason to delay a getaway to Salem any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Reserve one of our 5-star hotels in Salem and indulge in the finer things in life for a while. Don't wait any longer! ### 5-Star Hotels in Salem You'll have a wonderful time at one of these 5-star hotels. Michelin-starred restaurants, concierges, and in-room massages are all at the ready. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready for a wonderful adventure. How do you want to relax? 24-hour room service, so you can order that chocolate soufflé© in the wee hours of the morning? A mud wrap treatment that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. You won't sleep and order room service the entire time, though. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Salem are the perfect place to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. ### Your Getaway Starts Today The results are in, and Salem 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Select one of Expedia's Salem 5-star hotels today and decompress in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Salem? > - Search for the lowest price per night from $179 ### What makes a hotel 5 stars in Salem? ### Are there any 5-star all-inclusive resorts in Salem? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [3 Star Hotels in Tamassee ](https://www.expedia.com/3Star-Tamassee-Hotels.s30-0-d3000353238.Travel-Guide-Filter-Hotels) - [Tamassee Hotels ](https://www.expedia.com/Tamassee-Hotels.d3000353238.Travel-Guide-Hotels) - [Cabin Rentals in Tamassee ](https://www.expedia.com/Tamassee-Cabins.d3000353238-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Tamassee ](https://www.expedia.com/Tamassee-RV-Parks.d3000353238-aaRVParks.Travel-Guide-Accommodation) - [Chalets in Tamassee ](https://www.expedia.com/Tamassee-Chalets.d3000353238-aaChalets.Travel-Guide-Accommodation) - 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