Find hotels near Mayo Clinic, Downtown Rochester from $82

Search over 1 million properties and 550 airlines worldwide.

Save 10% or more on select stays with Expedia Rewards

Most hotels are fully refundable. Because flexibility matters.

Top Hotels Close to Mayo Clinic

Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
0.086 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $86 per night from Dec 18 to Dec 18
3.7/5 Good! (1,257 reviews)
"Great"

Reviewed on Nov 20, 2021

Kahler Inn and Suites - Mayo Clinic Area
5th Avenue Inn and Suites
2 out of 5
0.2 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $82 per night from Nov 28 to Nov 28
3.7/5 Good! (542 reviews)
"Basic Hotel. No coffee maker in room. Breakfast very limited. No cereal, No milk. Water very hot. Feel safe, Free Parking, Very close to Mayo Clinic, can get to subway level tunnels in Employee Parking across street so limited outdoor exposure."

Reviewed on Nov 24, 2021

5th Avenue Inn and Suites
Broadway Plaza, Trademark Collection by Wyndham
3 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $151 per night from Dec 17 to Dec 17
4.6/5 Wonderful! (112 reviews)
"Clean, spacious with lots of amenities, comfortable bed"

Reviewed on Sep 23, 2021

Broadway Plaza, Trademark Collection by Wyndham
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Marriott Rochester Mayo Clinic
3.5 out of 5
0.2 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $132 per night from Dec 3 to Dec 3
4.1/5 Very Good! (345 reviews)
"Really liked the indoor tall atrium courtyard with pool, hot tub, lounge chairs, skylight and glassed-in fitness center. The outdoor furniture and fake grass make for a good vibe even when the weather outdoors is cold. The only thing I noticed that was off was that the hot tub was out of ..."

Reviewed on Nov 24, 2021

Marriott Rochester Mayo Clinic
Brentwood Inn & Suites
2.5 out of 5
0.2 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $95 per night from Nov 28 to Nov 28
4.2/5 Very Good! (778 reviews)
"A good place to stay if you have appointments at the Mayo Clinic."

Reviewed on Nov 24, 2021

Brentwood Inn & Suites
The Towers At Kahler Grand Hotel
4 out of 5
0.087 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $314 per night from Nov 28 to Nov 28
4.6/5 Exceptional! (33 reviews)
"Perfect for anyone going to Mayo. Everything is connected by enclosed walkways. Friendly staff, well priced and very clean."

Reviewed on Nov 17, 2021

The Towers At Kahler Grand Hotel
RitaHouse 807 2nd St #8 · Solace and Rest in the Heart of the City
5/5 Exceptional! (1 review)
Better than a hotel
"Everything I needed. MN polar vortex outside. There was a heater. Everything in the fridge froze. Served my purpose."

Reviewed on Mar 15, 2021

Get rates
RitaHouse 807 2nd St #8 · Solace and Rest in the Heart of the City
Kahler Grand Hotel
3 out of 5
0.096 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $116 per night from Dec 9 to Dec 9
3.6/5 Good! (978 reviews)
"Check in was very easy, and the young lady thag helped chexk us in was very kind and incredibly helpful. Room was very large as well as the bathroom. Very clean!"

Reviewed on Nov 17, 2021

Kahler Grand Hotel
Residence Inn by Marriott Rochester Mayo Clinic Area
3 out of 5
0.2 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $103 per night from Dec 17 to Dec 17
4.2/5 Excellent! (149 reviews)
"Property was convenient and pleasant. Suited our purposes well."

Reviewed on Nov 12, 2021

Residence Inn by Marriott Rochester Mayo Clinic Area
DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
4 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $130 per night from Dec 3 to Dec 3
4.5/5 Wonderful! (637 reviews)
"Facility was very clean and convenient. Furnishings were comfortable and well maintained. We will stay here when we return. Staff was very friendly and bellman valet was exceptional."

Reviewed on Nov 25, 2021

DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
Hilton Garden Inn Rochester Downtown, MN
3 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $107 per night from Dec 10 to Dec 10
4.3/5 Excellent! (484 reviews)
"it was located within just a few walkable blocks to our concert"

Reviewed on Nov 13, 2021

Hilton Garden Inn Rochester Downtown, MN
Hilton Rochester Mayo Clinic Area
3.5 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $169 per night from Dec 11 to Dec 11
4.9/5 Exceptional! (144 reviews)
"Excellent service"

Reviewed on Nov 17, 2021

Hilton Rochester Mayo Clinic Area
KRB Apartments Civic Center
3 out of 5
0.4 mi from Mayo Clinic
3.8/5 Good! (4 reviews)
very pleasant
"walking distance to downtown and clinic. however, not to St Mary's hospital. We had a 2 bedroom, 2 bath, full kitchen with washer and dryer and large living room. Don't know if all the apartments are that large. very clean and comfortable. A problem with one of the toilets was fixed within hours. ..."

Reviewed on Jan 17, 2018

Get rates
KRB Apartments Civic Center
RitaHouse 2nd #6 · Charming Studio steps away from Mayo
5/5 Exceptional! (3 reviews)
Lovely Studio Apartment
"The neighborhood was very calm and had great areas to go on walks! The apartment was very classy and clean and felt very inviting! I would definitely recommend staying here if you’re making a trip to Rochester."

Reviewed on Jun 13, 2021

Get rates
RitaHouse 2nd #6 · Charming Studio steps away from Mayo
2 Connecting Suites with 3 beds and 1 sofabed at a Full Service Hotel by Suiteness
The price is $6,578 per night from Dec 4 to Dec 4
2 Connecting Suites with 3 beds and 1 sofabed at a Full Service Hotel by Suiteness
Modern studio just next to Mayo Clinic(807#2)
5/5 Exceptional! (2 reviews)
Great location, perfect for out of town Mayo treatment
"The property was perfect for our stay in Rochester, it was an easy 10min walk to the Mayo building and 12 min walk to St Marys campus (perfect for getting to/from Mayo appts without the hassle of parking). Kitchenette was nice for us to be able to cook and prep store bought foods, grocery store just ..."

Reviewed on Sep 11, 2021

Get rates
Modern studio just next to Mayo Clinic(807#2)
Hotel Indigo Rochester Downtown, an IHG Hotel
3.5 out of 5
0.3 mi from Mayo Clinic
Fully refundable
The price is $95 per night from Dec 3 to Dec 3
4.3/5 Excellent! (90 reviews)
"."

Reviewed on Nov 14, 2021

Hotel Indigo Rochester Downtown, an IHG Hotel
Riverview Suites
2.5 out of 5
0.5 mi from Mayo Clinic
4/5 Very Good! (26 reviews)
"Distance to the mayo clinic. Kitchen facilities. Dislike of front desk for check in"

Reviewed on May 19, 2021

Get rates
Riverview Suites
Hyatt House Rochester/Mayo Clinic Area
0.3 mi from Mayo Clinic
Fully refundable
The price is $110 per night from Dec 3 to Dec 3
4.2/5 Very Good! (71 reviews)
"Their breakfast is fabulous - far and above the traditional "free hotel breakfast." Also, at night they often serve a soup to guests free of charge. Little things like that are a big help for those on extended stays."

Reviewed on Nov 20, 2021

Hyatt House Rochester/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
0.4 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $109 per night from Nov 28 to Nov 28
3.9/5 Good! (650 reviews)
"Incredibly kind and helpful front desk staff. Spacious and comfortable rooms in main tower. Walking distance to Mayo Clinic and Methodist hospital."

Reviewed on Nov 20, 2021

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Don't see what you're looking for?
See all available properties in Mayo Clinic
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Recent reviews of Mayo Clinic hotels
expedia verified reviews