Find hotels near Mayo Clinic, Downtown Rochester from $59

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Compare 345 hotels close to Mayo Clinic with room rates, reviews, and availability. Most hotels are fully refundable.

Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
0.1 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $105 per night from Apr 13 to Apr 14
$105
per night
Apr 13 - Apr 14
7.4/10 Good! (1,010 reviews)
"It was a pleasant stay but as I see the parking was a big issue. My husband drove his Silverado truck and we were too big for one lot and the other lot had no room to park as the spots were for smaller vehicles. The only other interaction we had at check in and check out we had to wait for someone ..."

Reviewed on Mar 22, 2023

Kahler Inn and Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
3.5 out of 5
0.9 mi from Mayo Clinic
Fully refundable
The price is $110 per night from Apr 9 to Apr 10
$110
per night
Apr 9 - Apr 10
9.4/10 Exceptional! (323 reviews)
"Wow! 1st time staying at an Even property - VERY impressed! Front desk ladies were great! We were surprising a friend who was ringing the bell at Mayo. Great stay all the way around!"

Reviewed on Mar 28, 2023

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
0.3 mi from Mayo Clinic
Fully refundable
The price is $113 per night from Apr 9 to Apr 10
$113
per night
Apr 9 - Apr 10
8.8/10 Excellent! (317 reviews)
"New and clean, convenient to Mayo Clinic and Crave restaurant is always good on site!"

Reviewed on Mar 28, 2023

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel

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Kahler Grand Hotel
3 out of 5
0.096 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $128 per night from Mar 31 to Apr 1
$128
per night
Mar 31 - Apr 1
7.4/10 Good! (1,000 reviews)
"It was relaxing. Great location. Nice bathroom. My credit card was charged for parking 3 times totaling $40. Called once and they said the charges wouldn't go through but they all did."

Reviewed on Mar 23, 2023

Kahler Grand Hotel
GuestHouse Inn & Suites Rochester
2.5 out of 5
1.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $68 per night from Mar 30 to Mar 31
$68
per night
Mar 30 - Mar 31
7.8/10 Good! (1,000 reviews)
"Trip for Mayo. Shuttle service was helpful. I got here early due to snowstorm and my room was ready so I could rest. Very accommodating staff."

Reviewed on Mar 17, 2023

GuestHouse Inn & Suites Rochester
Hyatt House Rochester/Mayo Clinic Area
3.5 out of 5
0.3 mi from Mayo Clinic
Fully refundable
The price is $149 per night from Apr 7 to Apr 8
$149
per night
Apr 7 - Apr 8
9/10 Wonderful! (318 reviews)
Loved everything! Terrific stay!
"Awesome! Loved that the parking garage was connected to the hotel and had video surveillance. Loved the security in the elevator with needing our room key. The hotel was clean and beautiful, front desk guy was wonderful! Our room was amazing!! We ate at a pizza place right across the street and got ..."

Reviewed on Mar 27, 2023

Hyatt House Rochester/Mayo Clinic Area
Med City Hotel & Suites
2.5 out of 5
4.3 mi from Mayo Clinic
Fully refundable
The price is $71 per night from Apr 7 to Apr 8
$71
per night
Apr 7 - Apr 8
8.6/10 Excellent! (1,000 reviews)
"Good deal"

Reviewed on Mar 26, 2023

Med City Hotel & Suites
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $107 per night from Apr 9 to Apr 10
$107
per night
Apr 9 - Apr 10
9.8/10 Exceptional! (138 reviews)
"Lovely ambience. Desk staff very polite, helpful. Room is spacious and comfortable."

Reviewed on Mar 27, 2023

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Staybridge Suites Rochester - Mayo Clinic Area, an IHG Hotel
3 out of 5
0.9 mi from Mayo Clinic
Fully refundable
The price is $118 per night from Apr 9 to Apr 10
$118
per night
Apr 9 - Apr 10
9.2/10 Wonderful! (162 reviews)
"Very clean, modern, well-maintained and comfortable. They provided lots of in-room amenities and the entire staff was friendly and helpful."

Reviewed on Mar 25, 2023

Staybridge Suites Rochester - Mayo Clinic Area, an IHG Hotel
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4.4 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $80 per night from Apr 5 to Apr 6
$80
per night
Apr 5 - Apr 6
8.4/10 Very Good! (1,000 reviews)
"Very nice stay. Although the chlorine was overwhelming...couldn't stay in tbe pool atea long."

Reviewed on Mar 26, 2023

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Holiday Inn Express & Suites Rochester – Mayo Clinic Area, an IHG Hotel
2.5 out of 5
1.3 mi from Mayo Clinic
Fully refundable
The price is $103 per night from Apr 7 to Apr 8
$103
per night
Apr 7 - Apr 8
8.6/10 Excellent! (499 reviews)
"Easy access and very clean. Walking distance to the Mayo Health Care system."

Reviewed on Mar 16, 2023

Holiday Inn Express & Suites Rochester – Mayo Clinic Area, an IHG Hotel
Aspen Suites
3 out of 5
1.1 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $150 per night from Mar 31 to Apr 1
$150
per night
Mar 31 - Apr 1
8.8/10 Excellent! (425 reviews)
"Perfect location. Really clean Professional staff Wonderful experience"

Reviewed on Mar 26, 2023

Aspen Suites
Quality Inn near Medical Center
2.5 out of 5
5.1 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $70 per night from Mar 31 to Apr 1
$70
per night
Mar 31 - Apr 1
8/10 Very Good! (267 reviews)
"This property is well cared for. It is clean and comfortable, with all of the staff very friendly and helpful. Have stayed there twice in the last month. Two nights and the second time 4 nights. Price is very reasonable. Would stay again."

Reviewed on Mar 26, 2023

Quality Inn near Medical Center
Days Inn & Suites by Wyndham Rochester Mayo Clinic South
2.5 out of 5
3.6 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $59 per night from Apr 9 to Apr 10
$59
per night
Apr 9 - Apr 10
7.2/10 Good! (953 reviews)
"The only thing that really bothered me was the toilet was not flushing and we ended up fixing it our self because when we first arrived there they gave us a 1 queen bed then moved us to a 2q beds overall the stay was good price was the cheapest that i could find near the hospital"

Reviewed on Mar 10, 2023

Days Inn & Suites by Wyndham Rochester Mayo Clinic South
Microtel Inn & Suites by Wyndham Rochester South Mayo Clinic
3 out of 5
4.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $84 per night from Apr 18 to Apr 19
$84
per night
Apr 18 - Apr 19
8.2/10 Very Good! (1,001 reviews)
"We have stayed at this motel several times. It is in a convenient location, affordable, and welcomes well-behaved pets like our two corgis. They have a nice grassy area for walking your pets, as well."

Reviewed on Mar 27, 2023

Microtel Inn & Suites by Wyndham Rochester South Mayo Clinic
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
0.4 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $116 per night from Apr 15 to Apr 16
$116
per night
Apr 15 - Apr 16
8/10 Very Good! (811 reviews)
"We were surprised to have a suite as we didn't request one. We enjoyed having the Twigs restaurant right off the lobby...the food was very good."

Reviewed on Mar 24, 2023

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hilton Rochester Mayo Clinic Area
3.5 out of 5
0.3 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $178 per night from Apr 7 to Apr 8
$178
per night
Apr 7 - Apr 8
9.6/10 Exceptional! (226 reviews)
"Great place to stay for the concert we attended."

Reviewed on Mar 26, 2023

Hilton Rochester Mayo Clinic Area
Hampton Inn Rochester-South
2.5 out of 5
1.8 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $87 per night from Apr 7 to Apr 8
$87
per night
Apr 7 - Apr 8
8.8/10 Excellent! (776 reviews)
"Good breakfast. Nice check out time."

Reviewed on Mar 28, 2023

Hampton Inn Rochester-South
Aspen Select
3.5 out of 5
1.1 mi from Mayo Clinic
Fully refundableReserve now, pay when you stay
The price is $120 per night from Mar 30 to Mar 31
$120
per night
Mar 30 - Mar 31
8.6/10 Excellent! (820 reviews)
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Reviewed on Mar 27, 2023

Aspen Select
Country Inn & Suites by Radisson, Rochester, MN
2.5 out of 5
4.1 mi from Mayo Clinic
Fully refundable
The price is $93 per night from Apr 3 to Apr 4
$93
per night
Apr 3 - Apr 4
7.8/10 Good! (808 reviews)
"Only one night stay. Property is in nice condition. Shopping and dining options in the area are great."

Reviewed on Mar 27, 2023

Country Inn & Suites by Radisson, Rochester, MN
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Clinic hotels information

Number of reviews
12,854
Accommodation
345 hotels
Lowest Price
$59
Highest Price
$178

Hotels near Other Downtown Rochester Attractions

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 163 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Inn and Suites - Mayo Clinic Area is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers an indoor pool and a fitness center. Other good options close by include Kahler Grand Hotel and Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 163 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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