Important: This destination may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories for this destination before you book.

Find Hotels Near Mayo Clinic, Downtown

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Top Hotels Close to Mayo Clinic

Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
0.1 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $100 per night
3.7/5Good! (1,335 reviews)

"Due to Covid19 pandemic all amenities including breakfast , pool, excersize room suspended. Bathroom could use renovation ."…"

Reviewed on May 13, 2020

Kahler Inn and Suites - Mayo Clinic Area
Marriott Rochester Mayo Clinic
3.5 out of 5
0.1 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $159 per night
4.2/5Very Good! (282 reviews)

"I loved the facilities and staff. I have nothing negative to say."…"

Reviewed on Mar 8, 2020

Marriott Rochester Mayo Clinic
Broadway Plaza
3 out of 5
0.2 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $149 per night
4.6/5Wonderful! (90 reviews)

"Close proximity to Mayo clinic and a home like atmosphere"…"

Reviewed on Jun 4, 2020

Broadway Plaza
Residence Inn by Marriott Rochester Mayo Clinic Area
3 out of 5
0.2 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $129 per night
4.3/5Excellent! (128 reviews)

"The property was very clean, comfortable, and quiet, and the staff was very welcoming. Overall an excellent stay."…"

Reviewed on Nov 30, 2019

Residence Inn by Marriott Rochester Mayo Clinic Area
Brentwood Inn & Suites
2.5 out of 5
0.2 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $125 per night
4.2/5Very Good! (556 reviews)

"Close to clinic. The rooms were clean and very nice."…"

Reviewed on Apr 25, 2020

Brentwood Inn & Suites
DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
3.5 out of 5
0.2 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $135 per night
4.4/5Wonderful! (498 reviews)

"Super friendly and helpful staff. Especially the Bellmen."…"

Reviewed on May 23, 2020

DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
Kahler Grand Hotel
3 out of 5
0.071 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $92 per night
3.4/5Good! (2,154 reviews)

"Very friendly staff. Much of 1920's era hotel under renovation. Remodeled room was lovely and clean, with comfortable king bed. Most connected restaurants not open, but the grill offered great room service and quality for a low extra fee. Public ramp parking cost $16, but had 2nd floor access to ..."…"

Reviewed on Jun 2, 2020

Kahler Grand Hotel
5th Avenue Inn and Suites
2 out of 5
0.3 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $68 per night
3.6/5Good! (423 reviews)

"Love the location and the size of the room. I stayed 4 years ago and happy to see some upgrades. Would have liked to see them upgrade further by scraping the popcorn ceiling texture and wrapping the beams with wood. Could look really nice."…"

Reviewed on Mar 8, 2020

5th Avenue Inn and Suites
Hilton Rochester Mayo Clinic Area
3.5 out of 5
0.2 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $199 per night
4.9/5Exceptional! (72 reviews)

"We were in Rochester for a kidney transplant evaluation so cleanliness was important. I was impressed by the housekeeping staff. In addition, the entire hotel seemed well maintained. I would recommend more frequent cleaning of the workout facility. The pool area was clean. The room service was prompt ..."…"

Reviewed on Mar 14, 2020

Hilton Rochester Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field/Mayo Clinic Area
3 out of 5
0.4 mi from Mayo Clinic
Free CancellationReserve now, pay when you stay
The price is $100 per night
3.8/5Good! (463 reviews)

"I ended up with a cute one-bedroom apt in a building that is right next to the hotel. I had a separate bedroom and a full kitchen. I also had an outside entrance which is great because I had my little dog with me. Everyone there was very friendly and accommodating. I will always stay there when in ..."…"

Reviewed on May 1, 2020

Centerstone Plaza Hotel Soldiers Field/Mayo Clinic Area
Can't find the property you want?
See all available properties in Mayo Clinic
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. Rochester is home to 123 hotels and other accommodations, so you can find something that's perfect for your stay.

Staying Near Mayo Clinic

There are 52 hotels and accommodations within a mile of Mayo Clinic, including these picks:

  • Kahler Inn and Suites - Mayo Clinic Area: This 3.5-star hotel features free breakfast, a restaurant, and an indoor pool. Our customers like its quiet location and helpful staff.
  • Kahler Grand Hotel: This 3-star hotel features 3 restaurants, an indoor pool, and free WiFi. Our customers like its dining options and overall value.
  • Marriott Rochester Mayo Clinic: This 3.5-star hotel features a restaurant, an indoor pool, and free WiFi. It's a favorite with Expedia travelers for its dining options and clean, comfortable rooms.

Things to See and Do Near Mayo Clinic

Now that you've visited Mayo Clinic, you can discover the sights and attractions within just a few miles of the area.

You'll want to browse the exhibits at Rochester Art Center and Minnesota Children's Museum. Soldiers Field Veterans Memorial, Plummer House, and Assisi Heights are notable landmarks to explore if you're in the area. Get outside and spend some time strolling around Silver Lake Park, Quarry Hill Nature Center, and Douglas State Trail Head Rochester.

Mayo Civic Center and University of Minnesota-Rochester are both worth a visit while you're checking out the area. Spend some time checking out Shops University Square, which is 0.1 mi (0.2 km) from Mayo Clinic, or make a stop by Rochester Civic Theater, located 0.3 mi (0.5 km) away.

Frequently asked questions

What's the area like around Mayo Clinic?
Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you’re looking for a convenient place to stay, check out the 78 hotels and other accommodations you’ll find within a mile.
What's the best place to stay close to Mayo Clinic?
Adjacent to Mayo Clinic, Kahler Inn and Suites - Mayo Clinic Area is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers free breakfast and a restaurant. Other good options close by include Kahler Grand Hotel and Hilton Rochester Mayo Clinic Area.
If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?
Yes, you’ll find most room reservations are refundable if you cancel prior to the accommodation’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on “Search”, then filter by “free cancellation” to get the best deals near Mayo Clinic.
Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?
For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.
What can I see and do near Mayo Clinic?
You’ll want to browse the exhibits at Rochester Art Center and Minnesota Children’s Museum. Explore landmarks like Assisi Heights, Plummer House, and Mayowood Mansion. Local parks like Silver Lake Park, Quarry Hill Nature Center, and Douglas State Trail Head Rochester are peaceful spots to stop and take in some fresh air.

Recent reviews of Mayo Clinic hotels

More trip options