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Our top choices for Mayo Clinic hotels

1. Kahler Grand Hotel

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

Location: Downtown Rochester, < 0.1 mi from Mayo Clinic
Guest rating: 8.4/10 (Very good, 2415 reviews)
Price: $155 nightly, $178 total, Nov 26 - Nov 27, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Location and staff are wonderful, by Jennifer

2. Kahler Inn and Suites - Mayo Clinic Area

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

Location: Downtown Rochester, 0.1 mi from Mayo Clinic
Guest rating: 8.2/10 (Very good, 1715 reviews)
Price: $146 nightly, $169 total, Dec 4 - Dec 5, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Great location and nice and comfy rooms, by Laura

3. Hotel Indigo Rochester – Mayo Clinic Area by IHG

A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

Location: Downtown Rochester, 0.2 mi from Mayo Clinic
Guest rating: 8.8/10 (Excellent, 1003 reviews)
Price: $97 nightly, $112 total, Nov 28 - Nov 29, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: This was a nice hotel with a great location. There were several bars and restaurants within walking distance., by Kathleen

4. Hilton Rochester Mayo Clinic Area

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

Location: Downtown Rochester, 0.2 mi from Mayo Clinic
Guest rating: 9.6/10 (Exceptional, 657 reviews)
Price: $169 nightly, $195 total, Nov 27 - Nov 28, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Clean rooms, great staff, convenient location., by Jennifer

5. TownePlace Suites by Marriott Rochester Mayo Clinic Area

A coffee shop interior with a wooden counter, menu boards, and seating area.

Location: Kutzky Park, 0.2 mi from Mayo Clinic
Guest rating: 9.6/10 (Exceptional, 577 reviews)
Price: $137 nightly, $158 total, Nov 27 - Nov 28, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: This location is awesome if you are going to Mayo Clinic. What an easy walk to the clinic. Several great restaurants are also within walking distance., by Neil

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

A modern indoor patio with a fire feature, seating, and large windows.

Location: Kutzky Park, 0.6 mi from Mayo Clinic
Guest rating: 9.4/10 (Exceptional, 1001 reviews)
Price: $126 nightly, $145 total, Nov 26 - Nov 27, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Very nice, well kept, comfy beds, nice staff, by Ashley

7. Brentwood Inn & Suites

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

Location: Downtown Rochester, 0.2 mi from Mayo Clinic
Guest rating: 8.8/10 (Excellent, 1005 reviews)
Price: $120 nightly, $138 total, Nov 15 - Nov 16, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Our stay was very nice, by Anne

8. Marriott Rochester Mayo Clinic

A modern building with large glass windows and indoor plants.

Location: Downtown Rochester, 0.1 mi from Mayo Clinic
Guest rating: 8.4/10 (Very good, 579 reviews)
Price: $199 nightly, $229 total, Nov 27 - Nov 28, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Always clean, in a great location with many amenities. Staff are extremely helpful, by Christine

9. Hyatt House Rochester/Mayo Clinic Area

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

Location: Downtown Rochester, 0.3 mi from Mayo Clinic
Guest rating: 9/10 (Wonderful, 1003 reviews)
Price: $111 nightly, $128 total, Nov 27 - Nov 28, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Great stay., by Robert Blaise

10. Hilton Garden Inn Rochester Downtown, MN

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

Location: Downtown Rochester, 0.2 mi from Mayo Clinic
Guest rating: 8.8/10 (Excellent, 970 reviews)
Price: $118 nightly, $136 total, Dec 11 - Dec 12, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Great place, by Richard

11. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

A garden with a water feature, rocks, and yellow umbrellas.

Location: Historic Southwest, 0.4 mi from Mayo Clinic
Guest rating: 8.6/10 (Excellent, 1002 reviews)
Price: $114 nightly, $131 total, Nov 22 - Nov 23, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Great place to stay, by Jordan

12. Residence Inn by Marriott Rochester Mayo Clinic Area

An outdoor terrace with tables and chairs, a large umbrella, and a view of a modern building with string lights.

Location: Downtown Rochester, 0.2 mi from Mayo Clinic
Guest rating: 8.6/10 (Excellent, 213 reviews)
Price: $149 nightly, $172 total, Nov 26 - Nov 27, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Room was clean but the bed sheets should be replaced., by Keith

13. The Berkman

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

Location: Folwell, 0.9 mi from Mayo Clinic
Guest rating: 9.6/10 (Exceptional, 456 reviews)
Price: $210 nightly, $241 total, Dec 1 - Dec 2, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Excellent service and wonderful room!, by Suzette

14. Staybridge Suites Rochester - Mayo Clinic Area by IHG

A modern living room with a fireplace, comfortable seating, and large windows.

Location: Kutzky Park, 0.6 mi from Mayo Clinic
Guest rating: 9.4/10 (Exceptional, 566 reviews)
Price: $107 nightly, $123 total, Nov 25 - Nov 26, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Love this place!, by Sheri

15. Aspen Suites

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

Location: 0.8 mi from Mayo Clinic
Guest rating: 9/10 (Wonderful, 917 reviews)
Price: $139 nightly, $160 total, Nov 26 - Nov 27, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Room was clean, common areas were well kept, staff was friendly and accommodating., by Lee

16. Med City Inn & Suites - Mayo Clinic Area

An indoor swimming pool with a wooden ceiling, clear blue water, and seating areas around the pool.

Location: Kutzky Park, 1 mi from Mayo Clinic
Guest rating: 7.8/10 (Good, 1056 reviews)
Price: $75 nightly, $86 total, Dec 15 - Dec 16, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Great stay for the price. Will stay here again when visiting Rochester MN., by Stephanie

17. Aspen Select

A lobby with leather chairs, a reception desk, a TV, and a coffee station.

Location: Kutzky Park, 0.8 mi from Mayo Clinic
Guest rating: 8.4/10 (Very good, 1002 reviews)
Price: $135 nightly, $156 total, Nov 27 - Nov 28, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: The staff made us feel welcomed, by William Jr.

18. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

Location: Kutzky Park, 0.7 mi from Mayo Clinic
Guest rating: 8.6/10 (Excellent, 1001 reviews)
Price: $112 nightly, $128 total, Nov 22 - Nov 23, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Clean rooms & nice breakfast, by Jackie

19. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

Location: Kutzky Park, 0.9 mi from Mayo Clinic
Guest rating: 9.2/10 (Wonderful, 542 reviews)
Price: $110 nightly, $126 total, Nov 25 - Nov 26, Total with taxes and fees, for Our top choices for Mayo Clinic hotels
Review: Clean, spacious and very modern. Would definitely stay here again., by Paul

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
Hilton Rochester Mayo Clinic Area	9.6Exceptional657 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6Exceptional577 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6Exceptional755 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6Exceptional321 reviews	View
EVEN Hotel Rochester - Mayo Clinic Area by IHG	9.4Exceptional1,001 reviews	View

Top Mayo Clinic Hotel Reviews

Hilton Rochester Mayo Clinic Area

Address: 10 East Center Street, Rochester, MN, 55904, US
Location: Downtown Rochester
Star rating: 3.5/5
Guest rating: 9.6/10 (657 reviews)
Review: I got a notice from the state disease control about a sickness passses through the pool, and my child did get very sick after swimming in the pool. Everything else was excellent!, by Ryan, March 21, 2025, rated 10/10 Excellent

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Address: 601 2ND STREET SW, Rochester, MN, 55902, US
Location: Kutzky Park
Star rating: 3/5
Guest rating: 9.6/10 (577 reviews)
Review: This is a very clean and up to date facility. Beautifully immaculate room! I highly recommend staying here especially if you’re visiting the Mayo Clinic., by Neil, July 7, 2022, rated 10/10 Excellent

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

An outdoor patio area with a concrete floor, wooden fence, and string lights.

Location: Kutzky Park
Review: I was impressed with the condition of the interior. Everything looked new, hallway and room carpet was cushy and cleanliness was top notch. I loved the decor. The complimentary hot breakfast buffet had a nice variety with healthy options., by Donald, February 3, 2025, rated 10/10 Excellent

The Berkman

Address: 217 14th Ave SW, Rochester, MN, 55902, US
Location: Folwell
Star rating: 3/5
Guest rating: 9.6/10 (456 reviews)
Review: Mayo visit, very relaxing location. This is next to Mayo St Mary’s Hospital. The parking was temperature controlled, the weather was -10, so this was a bonus. We used a shuttle to get to Mayo building, the shuttle is extremely busy after 3pm. There was quite a wait. The room was roomy, laundry, large bathroom with tub, we were on floor 6. We will go there on our next visit., by denise, February 6, 2025, rated 10/10 Excellent

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Address: 101 11TH Avenue SW, Rochester, MN, 55902, US
Location: Kutzky Park
Star rating: 4/5
Guest rating: 9.4/10 (1001 reviews)
Review: Great property, with free laundry machines available for guests, with a modern and clean environment. Highly recommend for anyone, especially those needing to stay by the Mayo Clinic - St Mary's Campus., by ryan, March 27, 2025, rated 10/10 Excellent

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Address: 101 11th Ave SW, Rochester, MN, 55902, US
Location: Kutzky Park
Star rating: 3/5
Guest rating: 9.4/10 (566 reviews)
Review: I work at St. Mary’s as a travel RN and I love staying here., by Rachel, November 30, 2024, rated 10/10 Excellent

Residence Inn by Marriott Rochester Mayo Clinic Area South

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

Location: Rochester
Review: This is a super nice hotel, the best breakfast we have had at a hotel!! Beds were comfortable, pillows good. Nice fire pit area, we did not use the pool or hot tub. Walking or biking trails next to the hotel., by Jaci, September 21, 2024, rated 10/10 Excellent

Home2 Suites by Hilton Rochester Mayo Clinic Area

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

Location: Rochester
Review: This was probably our 10th stay here. We come back for the consistent comfort, cleanliness, service and great location. The shuttle drivers to Mayo Clinic are incredibly helpful, informative and considerate., by Mary, April 6, 2023, rated 10/10 Excellent

Broadway Plaza, Trademark Collection by Wyndham

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

Location: Downtown Rochester
Review: Clean, spacious with lots of amenities, comfortable bed, by miriam sue, September 23, 2021, rated 10/10 Excellent

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Address: 165 13th Avenue SW, Rochester, MN, 55902, US
Location: Kutzky Park
Star rating: 3/5
Guest rating: 9.2/10 (542 reviews)
Review: I had to stay for 2 weeks. The staff was very helpful and pleasant. The rooms were way more than I expected. The bed wasn’t the most comfortable but I managed. Breakfast was excellent. The shuttles to and from the Mayo buildings to the hotel were excellent. Made me feel at ease during a tough time. I would definitely stay here again., by Amy, November 5, 2022, rated 10/10 Excellent

Hyatt House Rochester/Mayo Clinic Area

Address: 110 Civic Center Drive NW, Rochester, MN, 55901, US
Location: Downtown Rochester
Star rating: 3/5
Guest rating: 9/10 (1003 reviews)
Review: The staff was super helpful, I had left something in my room and they called me and are mailing it back to me. Shows they have integrity not only their front staff but housekeeping. Goes along way in my book. We will be staying there again., by Chad, January 30, 2025, rated 10/10 Excellent

Candlewood Suites Rochester Mayo Clinic Area by IHG

A hotel with a stone facade, multiple windows, and a sign indicating it is Candlewood Suites.

Location: Rochester
Review: Very comfortable beds and pillows in our room. Room was bigger then we were expecting. Could have had more then 2 bath towels in a room ment to sleep 4 people., by Ashley, July 24, 2024, rated 10/10 Excellent

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

Location: Kutzky Park
Review: Staying at this hotel made our trip to Mayo very easy. Hotel is directly across the street from St. Mary's so I could just wheel my mom there easily and not hassle with moving the car and paying for parking at the hospital. It does cost $8 to park at the hotel., by Anonymous traveler, September 16, 2017, rated 10/10 Excellent

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Address: 220 S Broadway, Rochester, MN, 55904, US
Location: Downtown Rochester
Star rating: 3.5/5
Guest rating: 8.8/10 (1003 reviews)
Review: Property right downtown. Parking was easy to get at least on weekend when we were there with easy access to hotel from right floor of the garage. Some good restaurants within easy walking distance and the hotel restaurant is also very good., by Jay, October 8, 2024, rated 10/10 Excellent

Aspen Suites

Address: 1211 2nd Street, Rochester, MN, 55902, US
Location: Rochester
Star rating: 3/5
Guest rating: 9/10 (917 reviews)
Review: Fabulous staff, especially Sheila!!! very caring and friendly, the reason for the stay isn't always the best, and the staff understands this. From housekeeping to the kitchen to the front desk, you are amazing and I love you!!!!!!!! I have stayed here now 4 times, and each stay has been amazing. Thank you to all of you!!!, by Julie, October 25, 2016, rated 10/10 Excellent

Hilton Garden Inn Rochester Downtown, MN

Address: 225 S Broadway, Rochester, MN, 55904, US
Location: Downtown Rochester
Star rating: 3/5
Guest rating: 8.8/10 (970 reviews)
Review: We came up for my appointment at mayo clinic. The Hilton garden inn was very accommodating. Especially the walk ways connecting you to the hospital., by Anonymous traveler, October 17, 2015, rated 10/10 Excellent

Econo Lodge Mayo Clinic Area

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

Location: Rochester
Review: The staff at this hotel are amazing, friendly, helpful and cheerful! The room was really clean and comfortable. The breakfast provided had a good variety and was presented well. I would recommend the EconoLodge in Rochester to everyone., by Eileen, February 6, 2017, rated 10/10 Excellent

Brentwood Inn & Suites

Address: 123 Fourth Ave. NW, Rochester, MN, 55901, US
Location: Downtown Rochester
Star rating: 2.5/5
Guest rating: 8.8/10 (1005 reviews)
Review: I always stay here when I visit the Mayo Clinic. The underground subway is so convenient, the check in is always so friendly and the rooms are always clean. I haven't eaten the breakfast so I can't speak for that. The double rooms are a little older (but clean :) and the queen rooms have been updated but it is always a pleasure to stay., by Daniel, July 22, 2022, rated 10/10 Excellent

Hampton Inn Rochester-South

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

Location: Rochester
Review: Clean and stocked...the rooms were clean and the coffee area was stocked well. The rooms are really small. Not great if you need to spend a lot of time there, but they use the space well. No dressers but they have a wire drawer thing for your clothes. No safe in the rooms, which we are used to. Nice pull out shelf on night stand. Perfect for those that have a CPAP machine. The bathroom was pretty outdated-tub looked tired and lots of limescale on shower head. Zero counter space for doing..., by Ross, October 31, 2026, rated 10/10 Excellent

Spark by Hilton Rochester South

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

Location: Rochester
Review: Great value, by Jen, November 12, 2026, rated 10/10 Excellent

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