$324 Cheap Flights from Charlotte (CLT) to Florence (FLO)

View $324 flight on Tue, Nov 4, 2025Opens in a new window

Popular airlines from Charlotte-Douglas Intl. Airport (CLT) to Florence, SC (FLO-Florence Regional)

Cheap Flights from Charlotte to Florence (CLT-FLO)

Prices were available within the past 7 days and start at $324 for one-way flights and $327 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Apr 21 - Sat, Apr 25
CLT
Charlotte
FLO
Florence
$327 Roundtrip, found 7 hours ago
$327
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Apr 21 from Charlotte to Florence, returning Sat, Apr 25, priced at $327 found 7 hours ago
American Airlines
Fri, Feb 20 - Tue, Feb 24
CLT
Charlotte
FLO
Florence
$332 Roundtrip, found 6 days ago
$332
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Feb 20 from Charlotte to Florence, returning Tue, Feb 24, priced at $332 found 6 days ago
American Airlines
Mon, Nov 24 - Sat, Nov 29
CLT
Charlotte
FLO
Florence
$342 Roundtrip, found 2 days ago
$342
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Nov 24 from Charlotte to Florence, returning Sat, Nov 29, priced at $342 found 2 days ago
American Airlines
Tue, Mar 24 - Sat, Mar 28
CLT
Charlotte
FLO
Florence
$347 Roundtrip, found 4 days ago
$347
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Mar 24 from Charlotte to Florence, returning Sat, Mar 28, priced at $347 found 4 days ago
American Airlines
Sat, Mar 14 - Wed, Mar 18
CLT
Charlotte
FLO
Florence
$357 Roundtrip, found 2 days ago
$357
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Mar 14 from Charlotte to Florence, returning Wed, Mar 18, priced at $357 found 2 days ago
American Airlines
Thu, Jan 1 - Mon, Jan 5
CLT
Charlotte
FLO
Florence
$362 Roundtrip, found 2 days ago
$362
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Charlotte to Florence, returning Mon, Jan 5, priced at $362 found 2 days ago
American Airlines
Thu, Dec 25 - Mon, Dec 29
CLT
Charlotte
FLO
Florence
$367 Roundtrip, found 7 hours ago
$367
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Charlotte to Florence, returning Mon, Dec 29, priced at $367 found 7 hours ago
American Airlines
Tue, Apr 21 - Sat, Apr 25
CLT
Charlotte
FLO
Florence
$387 Roundtrip, found 7 hours ago
$387
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Apr 21 from Charlotte to Florence, returning Sat, Apr 25, priced at $387 found 7 hours ago
American Airlines
Thu, Dec 25 - Tue, Jan 6
CLT
Charlotte
FLO
Florence
$392 Roundtrip, found 6 days ago
$392
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 25 from Charlotte to Florence, returning Tue, Jan 6, priced at $392 found 6 days ago
American Airlines
Mon, Nov 24 - Sat, Nov 29
CLT
Charlotte
FLO
Florence
$402 Roundtrip, found 2 days ago
$402
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Nov 24 from Charlotte to Florence, returning Sat, Nov 29, priced at $402 found 2 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $443
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $443

Frequently asked questions

How much does a flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) cost?
Secure a cheap one-way flight from $324 or cheap return flight from $327 from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
The cheapest month to fly from CLT to FLO is April, when there's less demand. Off-peak season is typically when you'll find cheap fares for travel between these airports.
Which airlines fly direct from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
You can fly straight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) on an American Airlines flight.
What is the cheapest airline that flies from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest CLT to FLO flight.
How many flights per day from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
When flying out of Charlotte-Douglas Intl. Airport (CLT), you'll have a choice from an average of 2 daily direct flights to Florence Regional Airport (FLO).
What are the most popular departure times for flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
The 10 PM departures from CLT to FLO are the top choice for many travelers. Greater demand means you'll likely pay more for these departures. If you want to save money, choose a less crowded time to fly.
What day of the week has the most flights from CLT to FLO?
Travel on a Monday if you're searching for the best choice of flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO).
What is the earliest flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
Charlotte-Douglas Intl. Airport (CLT)'s first flight to Florence Regional Airport (FLO) takes off at approximately 9:31AM UTC-5. With a travel time of 1h 12m, you'll arrive at around 10:43AM UTC-5.
How long does it take to fly from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
It usually takes 1 hour and 3 minutes to travel the 100 mi from CLT to FLO.
What airline has the least delays from CLT to FLO?
With 85% of flights generally landing on time, American Airlines has the best on-time performance for direct flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO). To keep track of your flight status and receive notifications if anything changes, use the Expedia App.
What is the best time to fly from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
To avoid possible delays on the Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) route, travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Florence from Charlotte-Douglas Intl. Airport (CLT)?
If you're catching a direct flight from Charlotte-Douglas Intl. Airport (CLT) to Florence, you can touch down at either Myrtle Beach Intl. Airport (MYR) or Florence Regional Airport (FLO).
Is it cheaper to buy a plane ticket from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) last-minute?
Last-minute fares from CLT to FLO are usually more expensive. To lock in the best rates, start looking for flights ahead of time. That being said, if you can play around with your travel dates, it's possible to score a cheap ticket right before your trip.
Is it cheaper to book a CLT to FLO flight and hotel package?
Compared with arranging hotels and flights separately, booking a CLT to FLO flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place will take the hassle out of travel planning. Simply pick your flights and select from our wide range of stays, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
In most cases, you can cancel or modify your CLT to FLO flight. However, there may be additional fees, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, visit our Customer Service portal.

Travel information

Origin airport
Charlotte-Douglas Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$327
Distance
99 mi
Average flight time
1 hour 10 mins

Book with confidence

Charlotte to Florence Flights

The cheapest times to fly from Charlotte to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charlotte to Florence are during the month of April. You can find some of the cheapest flights from Charlotte to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charlotte to Florence

Sunday is one of the best days to book for cheap flights from Charlotte to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charlotte to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charlotte to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $324 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charlotte to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charlotte to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Charlotte to Florence Flights

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*Available to One Key members.