Plan your trip

A river flowing through a forest with trees and a cloudy sky.

Search Guest Houses in Cottleville

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

  • Check prices for these dates

    Check prices for these dates, December 12 – 13, 2026

    View in a map

    Our top choices for Cottleville guest houses

    1. In the center of all Historic Main Street has to offer

    A spacious living room with wooden beams, a television, a sofa, and a coffee table.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    View all properties

    Learn more about Cottleville

    Escape to Cottleville! Enjoy its jazz scene and live music.

    See all hotels in Cottleville

    A river flowing through a forest with trees and a cloudy sky.

    Top reviews in Cottleville

    Holiday Inn Express & Suites St Peters by IHG

    A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    Residence Inn by Marriott St. Louis Chesterfield

    An outdoor patio with a built-in grill, seating area, and stone walls.

    Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

    A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

    Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    Hampton Inn & Suites St. Louis/Chesterfield

    A modern hotel dining area with a long communal table, multiple chairs, and pendant lighting.

    Courtyard by Marriott St. Louis Chesterfield

    An outdoor patio area with wicker furniture and a central fire feature.

    Country Inn & Suites by Radisson, St. Charles Historic District

    A brick building with a sign reading "Country Inn & Suites."

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Holiday Inn Express & Suites Wentzville St Louis West by IHG

    A spacious lobby with a reception desk, seating area, and a conference room.

    Frequently Asked Questions

    What is the nightly rate for a guest house in Cottleville?

    Rates for Cottleville guest houses vary, but travelers can find great-value prices from $594 with Expedia. A range of factors can affect nightly rates, such as the location, the breakfast offering, and the range of amenities. Travelers looking for a good deal should consider looking for a midweek stay, as weekend rates at Cottleville guest houses tend to be higher. Remember to also use our filters to sort prices from low to high.

    What's the difference between a Cottleville guest house and a B&B?

    A guest house in Cottleville is typically a larger establishment with more rooms, offering a more hotel-like experience, and may provide additional amenities including luxury bedding. In contrast, a B&B is usually a smaller property that focuses primarily on providing a room and breakfast. A B&B is often more personal, and breakfast is typically included as part of the stay, but other services might be more limited compared to a guest house.

    Explore a world of travel with Expedia