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Even though there aren't any Expedia hotels in Holyhead, there are 9 within 19 miles.
The Tre-Ysgawen Hall is one good option you might want to consider.
The Black Boy Inn and the Celtic Royal Hotel are a couple of other options that you might not be aware of. They can be found 16 miles and 16 miles from the central hub of Holyhead. The South Stack Coastal Retreats is also in the vicinity, 6 miles away from the center.
Llanfairpwllgwyngyll is 15 miles to the southeast of Holyhead, and is home to the Baron Hill Golf Club and the Steven Jones Gallery. Should you wish to spend a night or two in Llanfairpwllgwyngyll, check Expedia's booking pages for the latest deals at the Hotel Port Dinorwic and Ty'n Rhos Country House. 16 miles to the east of Holyhead is Menai Bridge, which is home to the Château Rhianfa and The Management Centre. While in Menai Bridge, a couple of sights worth adding to your itinerary are Castell Aberlleiniog and The Penny Farthing Sweet Shop.
30 miles to the east of Holyhead is Llandudno, a regional center with a population of 15,000, home to great visitor attractions like the Rhos on Sea Golf Club, St. David's Church and Little Orme. You can also spend a little time at the Kalpa Bhadra Kadampa Buddhist Centre and St. David's Methodist Church. The Bodysgallen Hall & Spa and St. George's Hotel are a selection of Expedia-listed hotel options in Llandudno.
Now that you have learned a little about the hotel options in Holyhead, be sure to check out Expedia's Holyhead travel guide for the low-down on cultural and scenic attractions here.