A calm river surrounded by trees with Spanish moss, reflecting the clear blue sky.

Mayo Vacations from $329

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Your Mayo Vacation

Experience the unique character and personality of Mayo with a customized Mayo vacation package. From its rural countryside to its spectacular views, you'll never have a dull moment in this city. If seeing the sights is on your to-do list during your trip to Mayo, check out major attractions such as Lafayette Blue Springs State Park. Don't put off exploring this destination any longer. Your perfect Mayo vacation is a couple of clicks away with Expedia.

The Latest Mayo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jan 10 - Jan 16

    Westgate Vacation Villas Resort + Flight

    Kissimmee
    6 nights
    4.0 star property
    8.2/10 - Very good (2,131 reviews)
    "I love everything about this place definitely going back"
    Reviewed November 4, 2026
    Roundtrip • Boston (BOS) - Orlando (MCO)
    BOS - MCO • Nonstop MCO - PSM • Nonstop
    $706
    $329
    per traveler
    found 2 days ago
    Westgate Vacation Villas Resort
  • Jan 22 - Jan 28

    Margaritaville Cottages Orlando by Vstays with H2O Waterpark + Flight

    Kissimmee
    6 nights
    4.0 star property
    9.2/10 - Wonderful (1,000 reviews)
    Roundtrip • Boston (BOS) - Orlando (MCO)
    BOS - MCO • Nonstop MCO - BOS • Nonstop
    $1,757
    $857
    per traveler
    found 1 day ago
    Margaritaville Cottages Orlando by Vstays with H2O Waterpark
  • Dec 14 - Dec 19

    Disney's Animal Kingdom Lodge + Flight

    Bay Lake
    5 nights
    4.5 star property
    9.0/10 - Wonderful (1,001 reviews)
    Roundtrip • Boston (BOS) - Orlando (MCO)
    BOS - MCO • Nonstop MCO - BOS • 1 stop
    $3,140
    $1,583
    per traveler
    found 1 day ago
    Disney's Animal Kingdom Lodge
  • Jan 24 - Jan 28

    Westgate Cocoa Beach Resort + Flight

    Cocoa Beach
    4 nights
    4.0 star property
    8.6/10 - Excellent (577 reviews)
    "Great place!"
    Reviewed November 2, 2026
    Roundtrip • New York (NYC) - Orlando (MCO)
    LGA - MCO • Nonstop MCO - LGA • Nonstop
    $1,050
    $540
    per traveler
    found 1 day ago
    Westgate Cocoa Beach Resort
  • Jan 17 - Jan 23

    Westgate Towers Resort + Flight

    Kissimmee
    6 nights
    3.5 star property
    8.6/10 - Excellent (1,001 reviews)
    "La limpieza fue excelente"
    Reviewed October 28, 2026
    Roundtrip • New York (EWR) - Orlando (MCO)
    EWR - MCO • Nonstop MCO - EWR • Nonstop
    $747
    $384
    per traveler
    found 16 hours ago
    Westgate Towers Resort

Where to stay in and around Mayo

Mayo, a charming market town in north Florida, offers a delightful blend of outdoor adventures and scenic beauty. Explore its inviting downtown district, perfect for family outings or romantic getaways, and immerse yourself in the natural wonders that surround this picturesque destination.

Day

Families and nature enthusiasts looking for an outdoor getaway will find Day, Florida, to be an ideal base for their adventures. Here, you can explore the stunning Lafayette Blue Springs State Park, enjoy the serene Allen Mill Pond Spring, or unwind at the local park. Located in Mayo, Day provides easy access to these attractions, making it simple to dive into recreational and beach activities. Choosing Day for your stay ensures a memorable experience in a charming village setting.

O Brien

Experience the charm of O Brien, an excellent hub for adventurous travelers eager to explore Florida's natural beauty. With attractions like the Suwannee River for outdoor fun, the scenic Troy Spring State Park, and the quaint Branford Public Library, O Brien offers a perfect blend of adventure and relaxation. It’s about a 14-mile drive from Mayo, making it easy to access. Choosing O Brien for your stay ensures a memorable getaway filled with nature and excitement.

Dowling Park

If you are a nature-loving family traveler, look no further than Dowling Park, a charming village renowned for its outdoor adventure and scenic beauty. Visitors can explore the breathtaking Lafayette Blue Springs State Park, enjoy the serene waters of Allen Mill Pond Spring, and discover the historic Ghost Town of Ellaville. With its peak visitor seasons in April, July, and September, Dowling Park is a delightful retreat, located about 14 miles from Mayo, making it an excellent choice for your vacation stay.

Alton

Alton stands out as a prime spot for travelers seeking family-friendly adventures in nature. This charming village offers access to beautiful outdoor experiences, including the scenic Wes Skiles Peacock Springs State Park, the tranquil river nearby, and the community-focused Veteran's Memorial Park of Mayo. Located in Mayo, Alton provides easy transit options for exploring these attractions. With its inviting atmosphere and appealing amenities, choosing Alton for your stay ensures a memorable vacation experience.

Mcalpin

Travelers visiting the area often choose Mcalpin, especially families and nature enthusiasts seeking a budget-friendly getaway. This charming city offers easy access to the scenic Suwannee River, the beautiful Troy Spring State Park, and the inviting Baker Park, ensuring plenty of outdoor adventures. With moderately seasonal visitor numbers peaking in January and September to October, Mcalpin provides a vibrant atmosphere. Located about 15 miles from Mayo, Mcalpin is a smart choice for your next vacation, combining adventure with affordability.

Discover the most popular places to visit in Mayo

Mayo Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

What's the best vacation package for Mayo?

For travelers seeking a Mayo vacation package focused on value, or those preferring an independent stay, Cindys Motel is a strong option. Rated 8.8 out of 10, this motel provides amenities like a kitchenette and free WiFi, making it convenient for preparing your own meals. Travelers frequently praise its clean rooms and great staff.


Families and outdoor enthusiasts looking to explore Mayo's natural attractions will find a package with a stay at Cindys Motel well-suited. It's located about 6 miles from Lafayette Blue Springs State Park, and its kitchenette can be particularly useful for family trips. Guests often highlight the clean rooms and helpful staff.


If you're planning a Mayo vacation package and traveling with pets, Cindys Motel is a pet-friendly choice. This property, rated 8.8 out of 10, offers comfortable accommodations with air conditioning and free WiFi, with guests consistently noting the clean rooms and great staff.

How can I save money on a Mayo vacation package?

When you bundle, you can save up to 30%*. To save money on a Mayo package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.

What are the top things to do in Mayo?

A Mayo vacation offers plenty of outdoor and nature-focused activities, from exploring natural springs to enjoying family-friendly attractions:


Browse and book things to do in Mayo on Expedia.

Do you need to rent a car in Mayo, or is public transport enough?

For Mayo vacation packages with flights, a rental car is highly recommended for exploring the area. As an outdoor and nature destination outside a major city, Mayo has many attractions that are spread out. For instance, natural springs like Lafayette Blue Springs State Park are about 6 miles away, and family attractions like Wild Adventures are about 19 miles from central Mayo. While you can fly into JAX-Jacksonville Intl. Airport (JAX), which is about 94 miles from Mayo, a car provides the flexibility to visit these natural attractions and other points of interest at your own pace.

Are Mayo vacation package hotels conveniently located?

Mayo vacation package hotels offer convenient access to the town center and nearby natural attractions. For example, Cindys Motel, rated 8.8 out of 10 by travelers, is located about a 10-minute walk from central Mayo. This central location makes it easy to explore the local area and access the region's outdoor activities.

Can I change or cancel my Mayo vacation package if my plans change?

Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.

Do One Key members get extra savings when booking Mayo vacation packages?

Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.

Does Expedia offer Book Now, Pay Later Mayo vacation packages?

Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mayo vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.

How do I find last-minute vacation packages to Mayo?

To find last-minute vacation packages to Mayo, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.

How does free cancellation work on Mayo vacation packages?

Free cancellation on a Mayo vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.

Is it cheaper to book a Mayo vacation as a package or separately?

Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Mayo getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.

Why should I book my Mayo vacation package with Expedia?

Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.