Mission Valley Vacations from $270
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Your Mission Valley Vacation
With a vacation package to Mission Valley, you can spend less time planning and more time experiencing this interesting neighborhood. From its shopping to its dining, there's so much to discover here. Can't wait to do some sightseeing during your trip to Mission Valley? Don't miss nearby attractions like San Diego Zoo, Balboa Park and University of San Diego. Stop daydreaming and start doing. When you're ready to book your ideal vacation to Mission Valley, Expedia will help get you there.
The Latest Mission Valley Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Quiet Mind Mountain Lodge, Retreat and Spa
per person
Sep 8 - Sep 15
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to San Diego (SAN)
9.2/10 Wonderful! (524 reviews)
I would recommend this hotel. The rooms were very comfortable and the atmosphere was very laid back and wellness-centric.
Reviewed on Aug 7, 2025
The Sofia Hotel
Downtown San Diego
Save 100% on your flight
per person
Oct 10 - Oct 14
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.4/10 Very Good! (1,510 reviews)
The property says it has a restaurant and Bar which was a major factor in my booking since I am a female traveling alone for work in the city. I don’t like to walk around alone at night so like there to be amenities in the hotels. Very disappointing. Plus no microwave so I couldn’t even just get something for the room
Reviewed on Aug 9, 2025
Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
per person
Oct 10 - Oct 14
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (966 reviews)
Staff was friendly
Rooms were nice and comfortable
I wish the pool was open later. After a day of sightseeing, it’s nice to come back to the hotel and relax by the pool but it closed at 8, so we really couldn’t enjoy it.
Reviewed on Aug 7, 2025
Where to stay in Mission Valley
Find the best Mission Valley areas and neighborhoods for the activities you enjoy most. Learn more about Mission Valley
Downtown San Diego
2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Mission Valley Hotel Deals
Handlery Hotel
950 Hotel Cir N, San Diego, CA
$110 nightly
The price is $126 total per night from Aug 11 to Aug 12
$126 total
Aug 11 - Aug 12
Total includes taxes and fees
8/10 Very Good! (1,917 reviews)
"I think it was a good experience. Rooms were decent, the service is excellent. I will be coming back!"
Reviewed on Aug 8, 2025
Hampton Inn San Diego/Mission Valley
2151 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $154 total per night from Aug 17 to Aug 18
$154 total
Aug 17 - Aug 18
Total includes taxes and fees
8.6/10 Excellent! (1,158 reviews)
"Overall the hotel it’s nice. Just the room it’s small"
Reviewed on Aug 6, 2025
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S, San Diego, CA
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $111 total per night from Aug 11 to Aug 12
$111 total
Aug 11 - Aug 12
Total includes taxes and fees
7.8/10 Good! (2,261 reviews)
"It was a decent room for the price"
Reviewed on Aug 2, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission Valley
Hotel Circle
Hotel Circle is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Check out the shops and charming cafes in this family-friendly area.
Fashion Valley Mall
You can search for that perfect souvenir at Fashion Valley Mall during your stay in San Diego. Take in the fascinating museums and beautiful sunsets in this walkable area.
Snapdragon Stadium
Catch an event at Snapdragon Stadium during your trip to San Diego. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Things to do
Private Sidecar Winery Tour through San Diego
$165
per adult
Private Day Tour to Joshua Tree National Park from San Diego
$749
per traveler
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.