Downtown San Diego Vacations from $336

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Your Downtown San Diego Vacation

If you're craving a tourist adventure, our Downtown San Diego vacation packages are what you need. Whether you're searching for gift and craft shops, dining or nightlife, this neighborhood has something for every visitor. Your trip to Downtown San Diego wouldn't be complete without a stop at top attractions nearby such as San Diego Zoo, Balboa Park and Petco Park. Expedia is here to help put your travel plans into action. Book your dream Downtown San Diego vacation now.

The Latest Downtown San Diego Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Club Wyndham Harbour Lights
Coronado Beach Resort
Lakehouse Resort
Hampton Inn Cardiff Beach Encinitas, CA
City24 Hotel Little Italy Mission Hills

Where to stay in Downtown San Diego

Find the best Downtown San Diego areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Diego

Downtown San Diego Hotel Deals

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$296 nightly
The price is $343 total per night from Oct 10 to Oct 11
$343 total
Oct 10 - Oct 11
Total with taxes and fees
9/10 Wonderful! (2,832 reviews)
"Great area to explore"

Reviewed on Oct 2, 2025

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$177 nightly
The price is $205 total per night from Oct 12 to Oct 13
$205 total
Oct 12 - Oct 13
Total with taxes and fees
8.2/10 Very Good! (5,945 reviews)
"The hotel was nice the only downfall I have is they need to let guests know that it is 50.00 a day to park there."

Reviewed on Oct 1, 2025

Wyndham San Diego Bayside
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $138 total per night from Oct 13 to Oct 14
$138 total
Oct 13 - Oct 14
Total with taxes and fees
8.6/10 Excellent! (500 reviews)
"Room was clean and modern. Bed comfy. Was noisy beside the highway. Pool are very underwhelming."

Reviewed on Oct 2, 2025

The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Downtown San Diego

Things to do

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Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.