Title: Top Independent in Perryville, MO - Expedia.com [Perryville Travel Guide](https://expedia.com/Perryville.dx6134448)[Hotels in Perryville](https://expedia.com/Perryville-Hotels.d6134448.Travel-Guide-Hotels)[Vacation Rentals in Perryville](https://expedia.com/Perryville-Vacation-Rentals.d6134448.Travel-Guide-VacationRentals)[Flights to Perryville](https://expedia.com/Cheap-Flights-To-Perryville.d6134448.Travel-Guide-Flights)[Things to do in Perryville](https://expedia.com/Things-To-Do-In-Perryville.d6134448.Travel-Guide-Activities)[Car Rentals in Perryville](https://expedia.com/Car-Rentals-In-Perryville.d6134448.Car-Rental-Guide)[Perryville Vacation Packages](https://expedia.com/Perryville.d6134448.Destination-Travel-Guides) ![Arched train bridge](https://images.trvl-media.com/place/6134448/9dc94c46-c0ab-4d3f-b5fe-2d6ecd4d81c3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6134448/9dc94c46-c0ab-4d3f-b5fe-2d6ecd4d81c3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates Tonight [Mar 2 - Mar 3](https://www.expedia.com/Hotel-Search?regionId=6134448&startDate=2026-03-02&endDate=2026-03-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 3 - Mar 4](https://www.expedia.com/Hotel-Search?regionId=6134448&startDate=2026-03-03&endDate=2026-03-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6134448&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6134448&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Independent.0-0-d6134448--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Independent.0-0-d6134448--bIndependent.Travel-Guide-Filter-Hotels) ## Top Perryville Hotel Reviews ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "Friendly staff." [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Clean and spacous " [](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Town House Inn](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5eb3395a_y.jpg) ### Town House Inn 10/10 Excellent "The room was amazing clean and no problems " [](https://expedia.com/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg) ### Holiday Inn Express & Suites Perryville by IHG 10/10 Excellent "Room was great, front desk was professional but friendly. Breakfast was excellent. Spotless — both room and lobby. " [](https://expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 10/10 Excellent "New! Love the lobby layout, design and seating. Staff is super friendly and welcoming. Location is right next to the sports complex. " [](https://expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Comfort Suites Jackson-Cape Girardeau](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25_y.jpg) ### Comfort Suites Jackson-Cape Girardeau 10/10 Excellent "Overall the stay was amazing. Staff was nice easy to work with. Check in progress was fast and simple loved the location!! Quiet street had no issues at all. Definitely would stay again " [](https://expedia.com/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG 10/10 Excellent "Great staff, rooms nice and so clean , very quiet , great breakfast selection ! No complaints! " [](https://expedia.com/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Baymont by Wyndham Chester IL](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438_y.jpg) ### Baymont by Wyndham Chester IL 10/10 Excellent "Clean Room, staff always ready to assist with any issues." [](https://expedia.com/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Retreat Air - King Bed, Hot Tub & No cleaning fee](https://images.trvl-media.com/lodging/124000000/123750000/123743600/123743557/5b24ebbb_y.jpg) ### Retreat Air - King Bed, Hot Tub & No cleaning fee 10/10 Excellent "Great host. Would stay again." 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