Plan your trip

A sunset over a lake with a dock and a small settlement.

Find Resorts & Hotels with Spas in Princess Anne, MD

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices

    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

  • Check prices for these dates

    Check prices for these dates, December 15 – 16, 2026

    View in a map

    Our top choices for Princess Anne hotels with a spa

    1. Cypress River Inn & Spa

    A brick pathway leading to a pool area with a fence and potted plants.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    View all properties

    Choose what matters most at spa hotels in Princess Anne

    Pool

    Breakfast included

    Hot tub

    4 stars

    5 stars

    Find out more about Princess Anne

    Top Princess Anne attractions for a relaxing vacation

    In Princess Anne, Maryland, travelers seeking a rejuvenating getaway will find tranquility and charm at points like the serene Pocomoke River, perfect for kayaking or paddleboarding amidst nature. Nearby, the historic town of Princess Anne offers quaint shops and local eateries where you can savor fresh seafood, enhancing your stay with delightful culinary experiences. For a dose of culture, explore the University of Maryland Eastern Shore's beautiful campus, which often features art exhibits and performances that celebrate local talent. Nature enthusiasts will appreciate the nearby Deal Island Wildlife Management Area, which provides scenic trails and birdwatching opportunities. After a day of exploration, unwind at one of the local hotels that offer spa services, where attentive staff ensure a pampered experience, making it easy to recharge before your next adventure. Enjoy the comfort and convenience of staying close to these attractions while indulging in the quality treatment you deserve.

    Frequently Asked Questions

    Looking for a spa hotel in Princess Anne?

    Forget the stress of everyday life and book yourself a hotel with a spa. Check out the beaches in Princess Anne - worth a picture or two! Enjoy the shopping and many popular restaurants during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your weekend away.

    What's there to see and do in Princess Anne?

    Enjoy Princess Anne and visit Hytche athletic Center, Somerset County Library, and Princess Anne Town Hall. If you have extra time while you're in the area, you might want to stop by Manokin Park and Mount Vernon Beach.

    What is a Princess Anne spa hotel?

    Spa hotels in Princess Anne provide lodging and have an on-site spa offering services like couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

    Explore a world of travel with Expedia