A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

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Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7
No exact matches found, but these alternatives could be just right

Recommended hotels in Puxico

A modern hotel lobby with a bar area, seating, and artwork on the walls.

1. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (78 reviews)
"This place is Brand new and really great!"
United States
Bryan
$98 nightly
The price is $111
Oct 25 - Oct 26
Total with taxes and fees
Hampton Inn By Hilton Dexter
A spacious lobby with a reception desk, seating area, and large windows.

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,003 reviews)
"Clean, great food, excellent staff."
United States
Dean
$94 nightly
The price is $106
Oct 29 - Oct 30
Total with taxes and fees
Drury Inn & Suites Poplar Bluff
Pool

3. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (984 reviews)
"Good location, great staff, clean rooms."
United States
Rhonda
$91 nightly
The price is $102
Nov 1 - Nov 2
Total with taxes and fees
Hampton Inn Poplar Bluff
A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

4. Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (371 reviews)
"breakfast was good, staff friendly, pool area needs work"
United States
Edward
$69 nightly
The price is $78
Oct 15 - Oct 16
Total with taxes and fees
Dexter Inn
A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

5. Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (287 reviews)
"The place was okay for a night"
United States
Herman
$51 nightly
The price is $58
Nov 13 - Nov 14
Total with taxes and fees
Econo Lodge Dexter
A diner with booth seating, a checkered floor, and a counter with a cash register.

6. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (423 reviews)
"Staff was very friendly"
United States
Steven
$86 nightly
The price is $97
Nov 1 - Nov 2
Total with taxes and fees
Travelodge by Wyndham Dexter
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

7. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (970 reviews)
"Great staff, clean and spacious room and bathroom, great morning breakfast"
United States
Nancy
$97 nightly
The price is $109
Oct 25 - Oct 26
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff
A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.

8. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (792 reviews)
"Always an enjoyable stay"
United States
Nathan
$84 nightly
The price is $95
Oct 18 - Oct 19
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

9. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,000 reviews)
"Perfect stay for our last leg home of our trip home."
United States
Cindy
$79 nightly
The price is $88
Oct 15 - Oct 16
Total with taxes and fees
Motel 6 Poplar Bluff, MO
A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

10. OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (145 reviews)
"Great staff! Clean rooms and convinient"
United States
DIEGO
$69 nightly
The price is $78
Oct 15 - Oct 16
Total with taxes and fees
OYO Hickory House Inn
A hotel lobby with a reception desk, a blue sofa, a fireplace, and a television.

11. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (441 reviews)
"Excellent every things"
United States
Muhammad
$74 nightly
The price is $84
Nov 8 - Nov 9
Total with taxes and fees
Comfort Inn Poplar Bluff North
A campfire surrounded by benches in a wooded park area.

12. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello
Wappapello
10.0 out of 10, Exceptional, (1 review)
"Very cozy"
United States
Shea E.
$230 nightly
The price is $242
Nov 3 - Nov 4
Total with taxes and fees
Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello
A hotel room with a bed, two bedside lamps, a framed picture of a building, and a nightstand with a phone.

13. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (675 reviews)
"The rooms was clean ,staff friendly and for breakfast they have waffle, cereals, toast bread, yogurt and coffee."
United States
Diana
$67 nightly
The price is $76
Oct 29 - Oct 30
Total with taxes and fees
Super 8 by Wyndham Poplar Bluff Missouri
A kitchen with wooden cabinets, a stainless steel refrigerator, a stove, and a window.

14. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello
Williamsville
$234 nightly
The price is $248
Oct 15 - Oct 16
Total with taxes and fees
Hunting / Fishing Cabin at Lake Wappapello
A modern kitchen with stainless steel appliances, wooden cabinets, and a white countertop.

15. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
10.0 out of 10, Exceptional, (1 review)
"Perfect place for our stay on the way to North Carolina! Clean, cozy and convenient!"
United States
Robert G.
$160 nightly
The price is $172
Oct 18 - Oct 19
Total with taxes and fees
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
A two-story house with a front porch, a covered entryway, and a small garden with white flowers.

16. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very good, (38 reviews)
"Overall, it was a good experience. I would stay again."
United States
Tammy G.
$200 nightly
The price is $215
Oct 15 - Oct 16
Total with taxes and fees
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.

17. Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
9.4 out of 10, Exceptional, (6 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
$100 nightly
The price is $105
Oct 15 - Oct 16
Total with taxes and fees
Lake Wappapello
A hot tub with a wooden interior and a view of a forest through large windows.

18. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
Greenville
10.0 out of 10, Exceptional, (11 reviews)
"Cute, cozy, private getaway that you won't want to leave!"
United States
Jade G.
$260 nightly
The price is $274
Oct 19 - Oct 20
Total with taxes and fees
Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
A living room with a blue wall, a fireplace, a sofa, and a chair.

19. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (116 reviews)
"On street parking, quiet little town, absolutely beautiful little hotel, diner, and general store. Very unique! It’s a whole experience staying here. I would love an opportunity to stop here again if I’m ever going through this area again."
United States
Miranda
$117 nightly
The price is $127
Oct 15 - Oct 16
Total with taxes and fees
EC Reed's Mercantile and Hotel
A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

20. 40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
3.0 star property
Poplar Bluff
10.0 out of 10, Exceptional, (3 reviews)
"Beautiful place enjoyed our stay"
United States
Anonymous traveler
$281 nightly
The price is $297
Oct 21 - Oct 22
Total with taxes and fees
40-acre Poplar Bluff Nature Lovers Paradise!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Puxico Hotel Reviews

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

8/10 Good
"Our room was fine with new appliances. Creepy tv logo features your name. We did find the elevators were slow and noisy to the 4th floor. The pool was clean but not very big or deep. The gym was fine with satelite tv but there was a broken mirror. There was a 25$ charge when you walk in the door. I was not notified about. I had already paided for hotel insurance. Brrakfast was provided and okay. Uppers floors hallways were being humidfied and hot fans going."
Ashley 1-night trip
Posted 12 hours ago
Hampton Inn Poplar Bluff

Find out more about Puxico

Puxico Condo Rentals information

Number of reviews
4,423
Accommodation
0 Condo Rentals
Lowest Price
$58
Highest Price
$297

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