Beginning of main content

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check prices on hotels in San Diego

Best deal Sep 6 - Sep 8
Tonight Aug 19 - Aug 20
This weekend Aug 23 - Aug 25
Next weekend Aug 30 - Sep 1

Featured San Diego Non-Smoking Hotels

See all 2,200 Properties in San Diego

Estimated price for 1 night/2 adults

Ramada Hotel & Conference Center by Wyndham San Diego North
Ramada Hotel & Conference Center by Wyndham San Diego North
3.5 out of 5.0 5550 Kearny Mesa Rd, San Diego, CA
Free Cancellation
3.9/5 (71 reviews)
$90/ night for 2 guests

Clean, nice pool, spacious rooms. Conveniently located close to some good restaurants.

Reviewed on Aug 15, 2019
Good Nite Inn San Diego near SeaWorld
Good Nite Inn San Diego near SeaWorld
2.0 out of 5.0 3880 Greenwood St, San Diego, CA
Free Cancellation
4.0/5 (730 reviews)
$56/ night for 2 guests

We had a great stay. The room was clean, spacious and felt safe. The bed was good and I liked the tv we had. They have a safe box in the room which I thought was very useful and cool to have. I have no complaints. The bedding was clean, I checked for stains and bed bugs and I didn’t find any. I also ...

Reviewed on Aug 15, 2019
Holiday Inn Express San Diego - SeaWorld Area
Holiday Inn Express San Diego - SeaWorld Area
2.5 out of 5.0 3950 Jupiter St, San Diego, CA
Free Cancellation
4.2/5 (1653 reviews)
$101/ night for 2 guests

Old building, kind of musky. Very small pool. Shabby area

Reviewed on Aug 18, 2019
La Quinta Inn & Suites by Wyndham San Diego SeaWorld/Zoo
La Quinta Inn & Suites by Wyndham San Diego SeaWorld/Zoo
2.5 out of 5.0 641 Camino Del Rio S, San Diego, CA
Free Cancellation
3.6/5 (2018 reviews)
$99/ night for 2 guests

Location next to freeway and shopping but is not in the seaworld area like they advertise.

Reviewed on Aug 13, 2019
Courtyard by Marriott San Diego - Rancho Bernardo
Courtyard by Marriott San Diego - Rancho Bernardo
3.0 out of 5.0 11611 Bernardo Plaza Ct, San Diego, CA
Free Cancellation
4.3/5 (1216 reviews)
$95/ night for 2 guests

We liked it that it was next to a Christian Church

Reviewed on Aug 13, 2019
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5.0 1710 W Mission Bay Dr, San Diego, CA
Free Cancellation
4.1/5 (8450 reviews)
$129/ night for 2 guests

Beautiful pool beautiful views of the bay staff was very nice friendly and courteous

Reviewed on Aug 17, 2019
2 bd w/ Yard in Heart of Old Town-- WE Love Pets!
2 bd w/ Yard in Heart of Old Town-- WE Love Pets!
San Diego, California
5.0/5 (51 reviews)

Nice property right in Old Town San Diego. Close to great food and activities. Manager is very nice and even went out of her way to order us a card table to assemble puzzles on. Would stay there again anytime.

Reviewed on Jan 1, 2019
2 Bedroom Spanish Architecture, Modern Comfort & Design
2 Bedroom Spanish Architecture, Modern Comfort & Design
San Diego, California
4.4/5 (9 reviews)

The apartment was clean, neat and a perfect location. Beds were comfy too! The patio area was nice as well! We loved it! Close to airport and downtown!

Reviewed on Jan 1, 2018
4 Bedroom House in the Heart of Mission Beach! Steps to Beach and Bay!
4 Bedroom House in the Heart of Mission Beach! Steps to Beach and Bay!
San Diego, California
4.8/5 (36 reviews)

House is nicely decorated and had everything that we needed. Location is AMAZING! We would walk to the beach in the mornings and evenings. Boardwalk was great with our kids. The only negative I would say about this house is the parking, it's very tight! We were not able to get our 2 cars in the garage, ...

Reviewed on Mar 15, 2019
Map

Recently Booked Non-Smoking Hotels in San Diego

Pacific Terrace Hotel
4.0 out of 5.0
Last booking: 37 minutes ago
Blue Sea Beach Hotel
3.5 out of 5.0
Last booking: 48 minutes ago
Best Western Seven Seas
3.0 out of 5.0
Last booking: 58 minutes ago
Marriott Marquis San Diego Marina
4.0 out of 5.0
Last booking: 1 hour ago
Hilton San Diego Bayfront
4.0 out of 5.0
Last booking: 3 hours ago
Good Nite Inn San Diego near SeaWorld
2.0 out of 5.0
Last booking: 3 hours ago

Pocket Guide: Non-Smoking Hotels in San Diego

Search for hotels in San Diego on Expedia. You can easily find your hotels in San Diego using one of the methods below:

  • View our selection of featured hotels in San Diego
  • Use the map to find hotels in the San Diego neighborhood you prefer
  • Use the filters to see hotels in a specific area of San Diego, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in San Diego
  • Enter your travel dates to view the best deals on hotels in San Diego - while they last