San Francisco

Travel Guide

Hotel Mykonos Panama

Hotel Mykonos Panama

3.5 out of 5
Panamerican Highway Nuevo Santiago Veraguas
$90 nightly
The price is $99 total per night from Oct 15 to Oct 16
$99 total
Oct 15 - Oct 16
Total with taxes and fees
Book a stay at this spa hotel in Nuevo Santiago. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza Banconal and Omar Torrijos Herrera ...
8.8/10 Excellent! (600 reviews)
"Deben programar realizar limpiezas profundas en las habitaciones. El servicio por parte del staff, fue bueno. Sugiero variar el desayuno de manera intercalada (por días). Esto, para no repetir lo mismo."

Reviewed on Oct 12, 2026

Hotel Mykonos Panama
Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
$73 nightly
The price is $80 total per night from Oct 15 to Oct 16
$80 total
Oct 15 - Oct 16
Total with taxes and fees
Stay at this hotel in Santiago. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Plaza ...
Hotel Gran David
HOTEL VISTA LAGO

HOTEL VISTA LAGO

3 out of 5
Rincón Largo La Pena Santiago de Veraguas
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $76 total per night from Oct 23 to Oct 24
$76 total
Oct 23 - Oct 24
Total with taxes and fees
Stay at this hotel in La Pena. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Acuatico Italia Guadalupe Panama and Omar Torrijos ...
9.4/10 Exceptional! (126 reviews)
"Todo perfecto"

Reviewed on Sep 19, 2026

HOTEL VISTA LAGO
See all 18 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Perfect 1-bedroom bungalow with AC in peaceful Playa reina

Perfect 1-bedroom bungalow with AC in peaceful Playa reina

Santiago Provincia de Veraguas
Stay at this vacation home in Canto del Llano. Enjoy air conditioning. Popular attractions Parque Acuatico Italia Guadalupe Panama and Plaza Banconal are located ...
Perfect 1-bedroom bungalow with AC in peaceful Playa reina
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Panama Panamá
Stay at this vacation home in Santiago. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Catedral of Santiago Apostol and Omar Torrijos ...
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.
See all properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What cuisines can you find in San Francisco?
In San Francisco you can find Japanese cuisine, with options like sushi, ramen, and tempura. Travelers also enjoy a wide array of other choices, including Chinese, Vietnamese, and Indian dishes, as well as Mexican favorites like tacos and burritos, and Italian classics.
Can I book a refundable hotel in San Francisco?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in San Francisco by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to San Francisco with Expedia?
Expedia makes it easier to plan your San Francisco trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in San Francisco?
The best choice depends on your travel style. Hotels in San Francisco can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my San Francisco trip on Expedia?
Once you've booked your San Francisco trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my San Francisco trip?
Expedia offers customer support before, during, and after your San Francisco trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to San Francisco?
If it's your first trip to San Francisco, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my San Francisco hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your San Francisco hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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