Santa Clara Vacations from $683

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Your Santa Clara Vacation

Art, food, entertainment and more … There's so much to experience with a Santa Clara vacation package. And with the ability to customize your city getaway, it's guaranteed to be one you won't forget. Eager to sightsee but not sure where to start? Any trip to Santa Clara should include Culebra Cut. Your dream Santa Clara vacation is a couple of clicks away. Search flights, accommodations and more on Expedia for a getaway that's tailored just for you.

The Latest Santa Clara vacation packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,192, price is now $683 per person
$683
per person
Mar 12 - Mar 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
10/10 Exceptional! (1 review)
Room was spotless, front gate staff was really nice, loved the tiny gym on the main floor.

Reviewed on Dec 21, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,568, price is now $1,009 per person
$1,009
per person
Mar 31 - Apr 4
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
Breakfast and live music was excellent.

Reviewed on Jan 7, 2026

Playa Caracol Residences Vacation Rental

Playa Caracol Residences Vacation Rental

3.5 out of 5
Price was $1,394, price is now $961 per person
$961
per person
Mar 23 - Mar 30
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
7.2/10 Good! (26 reviews)
Great, clean condo overlooking the pool and ocean. We didn't cook our meals, but used the restaurant on site. Staff was friendly and professional.

Reviewed on Dec 7, 2025

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was $1,861, price is now $1,336 per person
$1,336
per person
Apr 3 - Apr 6
found 19 hours ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
8.6/10 Excellent! (1,396 reviews)
Excellent room for my family

Reviewed on Jan 5, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,391, price is now $1,047 per person
$1,047
per person
Mar 12 - Mar 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
water is provided every day. pool is very big. mall right across from the hotel.

Reviewed on Jan 6, 2026

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Discover the most popular places to visit in Santa Clara

Culebra Cut

You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.

Culebra Cut

What to do in Santa Clara

Monkey and Sloth Jungle Habitat Panama Tour

Monkey and Sloth Jungle Habitat Panama Tour

$60
per adult
100% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
Miraflores Visitor Center

Panamá Canal and Old Town

$80
per adult
Panamá Canal and Old Town
MiraLift

Transfer to Panama Canal (Miraflores Locks)

$14
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
See all activities in Santa Clara

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Jan 18 to Jan 19
$135 total
Jan 18 - Jan 19
Total with taxes and fees
9/10 Wonderful! (4,808 reviews)
Nice room and accommodations

Reviewed on Jan 6, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Jan 15 to Jan 16
$121 total
Jan 15 - Jan 16
Total with taxes and fees
8.4/10 Very Good! (2,371 reviews)
Love this hotel

Reviewed on Jan 5, 2026

Crowne Plaza Panama Airport by IHG
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $241 total per night from Jan 26 to Jan 27
$241 total
Jan 26 - Jan 27
Total with taxes and fees
8.4/10 Very Good! (1,351 reviews)
El hotel nos brindó una excelente atención.

Reviewed on Jan 4, 2026

Megapolis Hotel Panamá
See all 1,687 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Clara Vacation Packages

Santa Clara Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)
Population
1,400

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Frequently asked questions

How much does a Santa Clara vacation package cost?
You can snap up a vacation package to this destination from $683 on Expedia. However, how much your vacation to Santa Clara costs will depend on your hotel choice, season and length of stay.
What are the cheapest months to go to Santa Clara?
You're likely to find lower rates and greater availability in September, October and December. Browse our cheap Santa Clara vacation packages and you could score some great off-season deals.
How many days is enough for Santa Clara?
The ideal duration for your Santa Clara vacation depends on what you'd like to see and do. Typically, a handful of days to a week will give you plenty of time to hit all the main attractions and explore some hidden treasures along the way.
How to find the best Santa Clara package deals?
Landing a cheap Santa Clara package deal is easy with Expedia. After you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, add a few filters and browse what's available. You can tweak your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most affordable Santa Clara package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa Clara vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and stays separately. Better still, you can customize your Santa Clara trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a rental car. Check out our great deals to see how much you can save.
When to book a vacation package to Santa Clara?
If you have your Santa Clara vacation dates finalized, book as early as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
How to plan a trip to Santa Clara?

  1. Choose your travel dates: What you'd like to do in Santa Clara and your preferred season will help you decide when to get away.
  2. Figure out your budget: Ensure you have enough money to cover everything from meals and transportation to airfares and activities. Your accommodations will likely be the largest expense during your trip to Santa Clara.
  3. Use Expedia's trip planning tool to discover Santa Clara: Research every aspect of your trip to Santa Clara with this comprehensive planner. Invite friends or family to collaborate on a group trip, search for stays or things to do and make bookings.
  4. Decide how long to go for: Now that you're up to speed on Santa Clara, you can work out the ideal length of your vacation. Create a rough plan and allocate enough time to cover everything you want to do.
  5. Bundle your hotel and flights: Epic destination, check. Length of stay, check. All that's left now is to pick a Santa Clara vacation package that brings all your bookings together.
  6. Book experiences or activities in advance: Whether it's a ticket to a big attraction or a day trip, you won't have to worry about missing out on Santa Clara's best offerings. Find all the fun things to do in Santa Clara with our dedicated activity guide.

Does Expedia offer Book Now, Pay Later Santa Clara vacation packages?
Your Santa Clara trip is meant to be a relaxing escape from your busy life, not a reason for money worries. So to give you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there are no hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.