Title: The Best Business Hotels in Simpsonville, SC from $71 in 2026 | Expedia.com [Simpsonville Travel Guide](https://expedia.com/Simpsonville.dx6239)[Hotels in Simpsonville](https://expedia.com/Simpsonville-Hotels.d6239.Travel-Guide-Hotels)[Vacation Rentals in Simpsonville](https://expedia.com/Simpsonville-Vacation-Rentals.d6239.Travel-Guide-VacationRentals)[Flights to Simpsonville](https://expedia.com/Cheap-Flights-To-Simpsonville.d6239.Travel-Guide-Flights)[Things to do in Simpsonville](https://expedia.com/Things-To-Do-In-Simpsonville.d6239.Travel-Guide-Activities)[Car Rentals in Simpsonville](https://expedia.com/Car-Rentals-In-Simpsonville.d6239.Car-Rental-Guide)[Simpsonville Vacation Packages](https://expedia.com/Simpsonville.d6239.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/business.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/business.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Simpsonville Business Hotels Tonight [Mar 22 - Mar 23](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Mar 23 - Mar 24](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Simpsonville business-friendly hotels ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/5cc3b6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/0d8d0617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/51a7c4d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/42b56840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Greenville Simpsonville [](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) Simpsonville 9.0/10 Wonderful (684 reviews) "Great location, great service, great facility " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) henry $93 nightly $102 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/8683611a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/e99aa693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/9ddc6b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/w2868h1920x0y0-e40e27dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Simpsonville - Greenville [](https://www.expedia.com/Simpsonville-Hotels-Quality-Inn-Simpsonville-Greenville.h24842.Hotel-Information) Simpsonville 7.4/10 Good (177 reviews) "A good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher $66 nightly $72 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Quality-Inn-Simpsonville-Greenville.h24842.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/18e8e500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/94e05ad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/64221897.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/c06326d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG [](https://www.expedia.com/Simpsonville-Hotels-Holiday-Inn-Express-Suites-Greenville-SE-Simpsonville.h18989520.Hotel-Information) Simpsonville 9.4/10 Exceptional (522 reviews) "Friendly staff and everything was well kept." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronny $138 nightly $152 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Holiday-Inn-Express-Suites-Greenville-SE-Simpsonville.h18989520.Hotel-Information) ![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/0570b9fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/d8c4bcc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/e4cbaa99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/136fac21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Simpsonville [](https://www.expedia.com/Simpsonville-Hotels-Days-Inn-By-Wyndham-Simpsonville.h533881.Hotel-Information) Simpsonville 7.2/10 Good (429 reviews) "Clean and courteous " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard $76 nightly $84 total Apr 17 - Apr 18 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Days-Inn-By-Wyndham-Simpsonville.h533881.Hotel-Information) ![Suite, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/a3ff3e5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/772de931.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/ee72685c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/043ecbeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Simpsonville - Greenville [](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) Simpsonville 8.2/10 Very Good (805 reviews) "The property and the staff are great. Sometimes the other guest could be a little loud in the middle of the night, but it was the weekend." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia $105 nightly $115 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/92684d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1d70fbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.com/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.8/10 Excellent (147 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roymond $91 nightly $100 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/f18cfd05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/acae25f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/8ea6d425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/816f82a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Easley/Greenville [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) Easley 7.4/10 Good (792 reviews) "Spotless room, comfortable bed, friendly and attentive staff, breakfast was quite nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa $64 nightly $71 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/fd542db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/9b9d3bd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/0689cad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/c83ed6f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Travelers Rest Greenville [](https://www.expedia.com/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) Travelers Rest 7.6/10 Good (1,005 reviews) "Everything was wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra $88 nightly $97 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/d02ac737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/1b324965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/e845fce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/edb3bbb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Spartanburg Northwest [](https://www.expedia.com/Spartanburg-Hotels-Best-Western-Spartanburg-Northwest.h19764.Hotel-Information) Spartanburg 8.2/10 Very Good (858 reviews) "The staff is professional, kind, and helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nakia $88 nightly $98 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Spartanburg-Hotels-Best-Western-Spartanburg-Northwest.h19764.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/dfd5de25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/8ef1c109.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/7cd027cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed, Non Smoking (Efficiency) | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/edaae4f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Greenville Airport [](https://www.expedia.com/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) Greenville 8.2/10 Very Good (360 reviews) "Good location!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Willie $79 nightly $87 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06®ionId=6239&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Simpsonville Hotel Reviews ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Everything was great at this hotel " [](https://expedia.com/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Drury Inn & Suites Greenville](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 8/10 Good "Every thing was good" [](https://expedia.com/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/2e6ff142_y.jpg) ### Hyatt Regency Greenville 6/10 Okay "Room was so small. Had been told on phone we would have a city view room but instead had an internal room of lobby. It was a corner room an jumped up to elevator if we opened curtains anyone could see in. Beds were comfortable. Bathroom was incredibly small as well. Not worth the price paid overall. " [](https://expedia.com/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Room was immaculate - bed so comfy & fresh. Plenty of room. " [](https://expedia.com/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Hampton Inn Simpsonville](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/a7e2d124_y.jpg) ### Hampton Inn Simpsonville 10/10 Excellent "There was plenty of parking available " [](https://expedia.com/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-09ad394d_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "Great place to stay " [](https://expedia.com/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Comfort Suites Simpsonville - Greenville](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/a3ff3e5d_y.jpg) ### Comfort Suites Simpsonville - Greenville 10/10 Excellent "Friendly staff and comfortable room." [](https://expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) ![Aloft Greenville Downtown](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51_y.jpg) ### Aloft Greenville Downtown 10/10 Excellent "Great stay at Aloft Greenville Downtown! Super clean, modern rooms and an amazing location right in the heart of downtown. The staff was very friendly and helpful. I’d definitely stay here again!" [](https://expedia.com/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Fairfield Inn & Suites by Marriott Greenville Simpsonville](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/5cc3b6ae_y.jpg) ### Fairfield Inn & Suites by Marriott Greenville Simpsonville 10/10 Excellent "Great location, great service, great facility " [](https://expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) ## Frequently asked questions ### Which hotels to stay in Simpsonville as a business traveler? > Another great option is the [Fairfield Inn & Suites by Marriott Greenville Simpsonville](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information), where guests have given it an excellent score of 9.2\. This hotel not only provides free WiFi and a hearty breakfast but also features clean and comfortable rooms that are superb for business travellers. Many guests note the helpful and friendly service, ensuring a pleasant experience during your stay. > > > For those looking for a well-rated yet budget-friendly choice, the [Hampton Inn Simpsonville](https://www.expedia.com/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) is a solid pick, boasting an 8.8 rating. This hotel features free WiFi, self-parking, and a complimentary breakfast. Business travellers appreciate the great location and comfortable beds, as well as the friendly staff who are always ready to assist. > > > If you're seeking a spacious environment, the [Comfort Suites Simpsonville - Greenville](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) offers an appealing atmosphere with an 8.2 rating. This hotel provides a range of free amenities, including breakfast options and WiFi, along with a pool that adds a touch of leisure to your business trip. Guests frequently comment on the neat and clean rooms, along with the helpful staff, making it a welcoming retreat after a busy day. ### How much does a business hotel in Simpsonville cost? ### What business amenities should I look for in a hotel in Simpsonville? ### How can I save on a business hotel in Simpsonville with Expedia? ### Can I cancel my business hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Heritage Park ](https://www.expedia.com/Heritage-Park-Hotels.0-l553248621561867565-0.Travel-Guide-Filter-Hotels) - [Hotels near Discovery Island Water Park ](https://www.expedia.com/Discovery-Island-Water-Park-Hotels.0-l553248621532656705-0.Travel-Guide-Filter-Hotels) - [Hotels near Golden Lanes and Golden Skate ](https://www.expedia.com/Golden-Lanes-And-Golden-Skate-Hotels.0-l553248621532656706-0.Travel-Guide-Filter-Hotels) - [Hotels with Restaurants in Mauldin ](https://www.expedia.com/Mauldin-Hotels-Hotels-With-Restaurants.0-0-d183944-tHotelswithRestaurants.Travel-Guide-Filter-Hotels) - 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