Title: The Best Business Hotels in Simpsonville, SC from $63 in 2026 | Expedia.com [Simpsonville Travel Guide](https://expedia.com/Simpsonville.dx6239)[Hotels in Simpsonville](https://expedia.com/Simpsonville-Hotels.d6239.Travel-Guide-Hotels)[Vacation Rentals in Simpsonville](https://expedia.com/Simpsonville-Vacation-Rentals.d6239.Travel-Guide-VacationRentals)[Flights to Simpsonville](https://expedia.com/Cheap-Flights-To-Simpsonville.d6239.Travel-Guide-Flights)[Things to do in Simpsonville](https://expedia.com/Things-To-Do-In-Simpsonville.d6239.Travel-Guide-Activities)[Car Rentals in Simpsonville](https://expedia.com/Car-Rentals-In-Simpsonville.d6239.Car-Rental-Guide)[Simpsonville Vacation Packages](https://expedia.com/Simpsonville.d6239.Destination-Travel-Guides) ![Famous Simpsonville clock tower in the USA](https://images.trvl-media.com/place/6239/355ba173-9c9b-4721-b4ab-56062dbc25e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6239/355ba173-9c9b-4721-b4ab-56062dbc25e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Simpsonville Business Hotels Tonight [Apr 6 - Apr 7](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-04-06&endDate=2026-04-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Apr 7 - Apr 8](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6239&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Simpsonville business-friendly hotels ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/5cc3b6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/51a7c4d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/95c63f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/0d8d0617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Greenville Simpsonville [](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) Simpsonville 9.0/10 Wonderful (692 reviews) "Great location, great service, great facility " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) henry $93 nightly $102 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/8683611a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/e99aa693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/96d12f53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Upgrade) | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24900/24842/9ddc6b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Simpsonville - Greenville [](https://www.expedia.com/Simpsonville-Hotels-Quality-Inn-Simpsonville-Greenville.h24842.Hotel-Information) Simpsonville 7.6/10 Good (184 reviews) "A good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher $66 nightly $72 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Quality-Inn-Simpsonville-Greenville.h24842.Hotel-Information) ![Suite, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/a3ff3e5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/ee72685c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/b0c859da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/3000000/2990000/2986100/2986074/772de931.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Simpsonville - Greenville [](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) Simpsonville 8.2/10 Very Good (813 reviews) "Nice, clean property with an attentive staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason $99 nightly $108 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/18e8e500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/b9fd26fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/94e05ad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18990000/18989600/18989520/c06326d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG [](https://www.expedia.com/Simpsonville-Hotels-Holiday-Inn-Express-Suites-Greenville-SE-Simpsonville.h18989520.Hotel-Information) Simpsonville 9.4/10 Exceptional (525 reviews) "The property was very nice! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tony $130 nightly $143 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Holiday-Inn-Express-Suites-Greenville-SE-Simpsonville.h18989520.Hotel-Information) ![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/0570b9fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/d8c4bcc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/dc2b86f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/533900/533881/136fac21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Simpsonville [](https://www.expedia.com/Simpsonville-Hotels-Days-Inn-By-Wyndham-Simpsonville.h533881.Hotel-Information) Simpsonville 7.2/10 Good (430 reviews) "I live in Cherokee and come here to visit family and I always stay here. The owners are really nice and the rooms are clean. Super convenient to surrounding restaurants and businesses. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher $76 nightly $84 total Apr 18 - Apr 19 Total with taxes and fees [](https://www.expedia.com/Simpsonville-Hotels-Days-Inn-By-Wyndham-Simpsonville.h533881.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1d70fbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.com/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.8/10 Excellent (168 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roymond $87 nightly $95 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/fd542db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/c83ed6f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/9b9d3bd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/a7c81686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Travelers Rest Greenville [](https://www.expedia.com/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) Travelers Rest 7.6/10 Good (1,002 reviews) "It was very clean. The staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JEANNETTE $88 nightly $97 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/f18cfd05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/8ea6d425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/816f82a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/ca1bd62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Easley/Greenville [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) Easley 7.4/10 Good (797 reviews) "Fantastic place and staff most accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Walter $64 nightly $71 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/dfd5de25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/7cd027cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/26c9fcbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/8ef1c109.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Greenville Airport [](https://www.expedia.com/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) Greenville 8.2/10 Very Good (380 reviews) "Good location!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Willie $67 nightly $74 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/26200/26192/5aef78e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26192/33744bae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26192/67411a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26192/fa836ed9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Spartanburg Waccamaw [](https://www.expedia.com/Spartanburg-Hotels-Days-Inn-By-Wyndham-Spartanburg-Waccamaw.h26192.Hotel-Information) Spartanburg 7.4/10 Good (820 reviews) "I enjoyed my stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rulley $57 nightly $63 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Spartanburg-Hotels-Days-Inn-By-Wyndham-Spartanburg-Waccamaw.h26192.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-20&endDate=2026-04-21®ionId=6239&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Simpsonville Hotel Reviews ![Aloft Greenville Downtown](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51_y.jpg) ### Aloft Greenville Downtown 10/10 Excellent "Everything was in place and hotel staff went out of their way to make us feel welcomed." [](https://expedia.com/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Drury Inn & Suites Greenville](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Hot tub was nice and beds were comfy " [](https://expedia.com/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Hampton Inn Simpsonville](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/a7e2d124_y.jpg) ### Hampton Inn Simpsonville 8/10 Good "broken door (deadbolt)" [](https://expedia.com/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Clean and nice. " [](https://expedia.com/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/605b3e5f_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "Staff was wonderful Bresyln she was very helpful from the first call I made to check in early she made sure I had everything I needed and the room in the perfect spot!! Thanks so much we will definitely will be back!! " [](https://expedia.com/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 8/10 Good "Beds could be comfier, but clean and friendly " [](https://expedia.com/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Fairfield Inn & Suites by Marriott Greenville Simpsonville](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/5cc3b6ae_y.jpg) ### Fairfield Inn & Suites by Marriott Greenville Simpsonville 10/10 Excellent "Yes" [](https://expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-09ad394d_y.jpg) ### Hyatt Place Greenville/Haywood 8/10 Good "It was good " [](https://expedia.com/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg) ### Hilton Greenville 10/10 Excellent "Everything went smooth and the rooms were clean and spacious. The $10/night parking is a bit steep but what are you going to do " [](https://expedia.com/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ## Frequently asked questions ### Which hotels to stay in Simpsonville as a business traveler? > Another great option is the [Fairfield Inn & Suites by Marriott Greenville Simpsonville](https://www.expedia.com/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information), where guests have given it an excellent score of 9.2\. This hotel not only provides free WiFi and a hearty breakfast but also features clean and comfortable rooms that are superb for business travellers. Many guests note the helpful and friendly service, ensuring a pleasant experience during your stay. > > > For those looking for a well-rated yet budget-friendly choice, the [Hampton Inn Simpsonville](https://www.expedia.com/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) is a solid pick, boasting an 8.8 rating. This hotel features free WiFi, self-parking, and a complimentary breakfast. Business travellers appreciate the great location and comfortable beds, as well as the friendly staff who are always ready to assist. > > > If you're seeking a spacious environment, the [Comfort Suites Simpsonville - Greenville](https://www.expedia.com/Simpsonville-Hotels-Comfort-Suites-Simpsonville.h2986074.Hotel-Information) offers an appealing atmosphere with an 8.2 rating. This hotel provides a range of free amenities, including breakfast options and WiFi, along with a pool that adds a touch of leisure to your business trip. Guests frequently comment on the neat and clean rooms, along with the helpful staff, making it a welcoming retreat after a busy day. ### How much does a business hotel in Simpsonville cost? ### What business amenities should I look for in a hotel in Simpsonville? ### How can I save on a business hotel in Simpsonville with Expedia? ### Can I cancel my business hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Heritage Park ](https://www.expedia.com/Heritage-Park-Hotels.0-l553248621561867565-0.Travel-Guide-Filter-Hotels) - [Hotels near Discovery Island Water Park ](https://www.expedia.com/Discovery-Island-Water-Park-Hotels.0-l553248621532656705-0.Travel-Guide-Filter-Hotels) - [Hotels near Golden Lanes and Golden Skate ](https://www.expedia.com/Golden-Lanes-And-Golden-Skate-Hotels.0-l553248621532656706-0.Travel-Guide-Filter-Hotels) - [Hotels with Restaurants in Mauldin ](https://www.expedia.com/Mauldin-Hotels-Hotels-With-Restaurants.0-0-d183944-tHotelswithRestaurants.Travel-Guide-Filter-Hotels) - 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