Find hotels in Cairo, IL from $67

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Our top choices for Cairo hotels

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
$71 nightly
The price is $79
Jan 17 - Jan 18, 2026
Total with taxes and fees
Quality Inn Cairo I-57

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
"Quiet and convenient."
United States
Alma
$64 nightly
The price is $69
Dec 25 - Dec 26
Total with taxes and fees
La Center Motel

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
"Staff was great! Room was nice. "
United States
Lana
$62 nightly
The price is $69
Dec 25 - Dec 26
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
$60 nightly
The price is $67
Dec 25 - Dec 26
Total with taxes and fees
Eagle Inn Charleston

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
$271 nightly
The price is $290
Dec 27 - Dec 28
Total with taxes and fees
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

More cheap stays in Cairo

Hotels in Cairo with star-rating

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Enjoy activities like hiking, riverboat tours, and camping in scenic areas around Cairo.
  • Rich History: Explore local historic forts and immerse yourself in the region's heritage.
  • Mississippi River Views: Experience breathtaking views and leisure activities along the iconic river.
  • Charming Accommodations: Choose from unique lodging options, including agritourism properties and cozy motels.
  • Local Culture: Visit shops and enjoy the warm atmosphere for a taste of regional culture.

Find great hotels in and around Cairo

Explore the unique lodging options in Cairo, Illinois, where you can choose from charming agritourism properties to cozy motels. Whether you're traveling with family, on a business trip, or bringing along your pet, you'll find a range of accommodations tailored to your needs. Discover the best hotels in Cairo, read reviews, and enjoy a memorable stay in this quaint destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Situated 10 miles from Cairo, Super 8 by Wyndham Charleston/Sikeston East MO offers a welcoming atmosphere for families and pet owners. This motel features child-friendly amenities such as complimentary cribs, ensuring a convenient stay for those traveling with little ones. The pet-friendly policy allows for some furry companions, making it an ideal choice for families looking to travel together. Guests can enjoy a comfortable environment with essential amenities and a friendly staff dedicated to providing a pleasant experience.
  • Quality Inn Charleston - Sikeston: Located 12 miles from Cairo, Quality Inn Charleston - Sikeston is a business-centric hotel that caters to professionals while still being pet-friendly. With a well-equipped business center, this hotel provides essential services for those traveling for work. The property has a pet policy that accommodates service animals and permits pets with some restrictions, making it a versatile choice for both business and leisure travelers. Guests appreciate the blend of functionality and comfort, making their stay productive and enjoyable.
  • Quality Inn Cairo I-57: Nestled in Cairo, Quality Inn Cairo I-57 is a family-friendly hotel that welcomes pets and offers a range of amenities for children, including complimentary cribs and first aid kits for peace of mind. The hotel’s pet-friendly policy allows dogs, with considerations for cleaning fees and restrictions, making it a suitable option for dog owners. With a commitment to family comfort and safety, guests will find a cozy atmosphere where they can relax after a day of exploration in Cairo.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventure and rich history, perfect for family-friendly vacations. Explore the scenic views along the Mississippi River, visit local shops for a taste of regional culture, and enjoy the warm weather. Nearby towns provide additional experiences with their charming atmospheres and business-friendly environments. Whether you're hiking in the great outdoors or immersing yourself in local heritage, Cairo promises an unforgettable getaway.

  • Wickliffe: Located a short 6 miles from Cairo, Wickliffe is a charming city known for its outdoor beauty and romantic atmosphere. Visitors flock here for its stunning scenery, making it an ideal destination for couples and nature lovers alike. Wickliffe offers a variety of recreational areas and a delightful resort, providing ample opportunities for relaxation and adventure. You can explore the nearby national parks and lakes, perfect for hiking, picnicking, or simply enjoying the scenic views. The arts center also adds a cultural touch to your visit, making Wickliffe a well-rounded destination.
  • Mound City: Also situated about 6 miles from Cairo, Mound City is a vibrant spot for those seeking outdoor adventures and scenic explorations. This city appeals to thrill-seekers and nature enthusiasts, offering a variety of activities like golfing and educational experiences. The proximity to beautiful lakes, a national park, and lush forests creates a perfect backdrop for hiking, fishing, or leisurely strolls. Mound City’s welcoming atmosphere and diverse attractions ensure a memorable experience for all visitors, especially in the bustling months of March, July, and October.
  • Wyatt: A quaint city located 7 miles from Cairo, Wyatt is perfect for travelers looking for romance and outdoor tranquility. Visitors are drawn to its serene landscapes and recreational areas, ideal for a peaceful escape. The nearby national park and picturesque lakes offer opportunities for boating, fishing, and hiking, making it a great spot to connect with nature. With peak travel times occurring during the warmer months of June to August, Wyatt promises a relaxing getaway filled with beautiful scenery and memorable experiences.

Things to do near Cairo

Cairo, Illinois offers a variety of outdoor adventures and scenic experiences perfect for a vacation. Visitors can enjoy recreational areas for relaxation, explore local golf courses, and partake in riverboat tours along the waterways. For those seeking weekend getaways, there are also camping sites available, along with opportunities for indoor activities. Whether you're looking to unwind or explore, Cairo provides a unique blend of activities for every traveler.

Shopping

Cairo offers charming local shops for unique gifts and souvenirs. For a wider selection, check out the nearby Plaza Shopping Center, about 10 miles away, featuring various retail stores and dining options. If you're up for a drive, you can explore the larger shopping malls in the surrounding areas.

Recreation

eDen Spa & Salon offers a rejuvenating body treatment experience just 28 miles from Cairo. This tranquil venue is designed for wellness and relaxation, providing a perfect escape to unwind and recharge while indulging in professional spa services.

Adventure

Visit Cape Splash Family Aquatic Center for an exciting waterpark experience, located 31 miles from Cairo. Enjoy thrilling slides, wave pools, and family-friendly attractions. For an outdoor adventure, hike the Limekin Springs Trail Trailhead, situated 20 miles away, where you'll find beautiful scenery and invigorating trails.

Nightlife

Experience the vibrant nightlife at the Cairo VFW Post 5222, where you can enjoy live music and friendly conversation. For a laid-back evening, visit the local diner for classic American fare and a cozy atmosphere, perfect for unwinding after a day of exploration.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Cairo

To save money on your trip to Cairo, Illinois, consider visiting between November and January for lower accommodation rates, with Tuesday being the cheapest day to stay. Utilize Expedia to find budget-friendly options by sorting prices and filtering for Eco-certified hotels. Combine your hotel, flights, and activities for package savings, and join the One Key membership for exclusive discounts and cash rewards. Take advantage of free local attractions and use public transport for economical travel around the city to maximize your experience without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are November to January, where the prices are slightly lower. This is in comparison to April to June, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Cairo is Tuesday. The most expensive day to stay in Cairo is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to tailor your options based on your budget, desired location, and hotel type. For instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are currently available. To find the best prices and offers, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Cairo with your flights and activities through an Expedia package deal.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions in and around Cairo

Cairo, Illinois, is a great destination for outdoor enthusiasts and adventure seekers. Visitors can explore local attractions such as national parks, nature preserves, and historic forts. The area offers a blend of cultural experiences and scenic beauty, perfect for those looking to immerse themselves in nature or learn about the region's history. Don't miss out on a visit to Cairo itself to fully appreciate its charm and attractions.

  • Fort Defiance State Park: This historic fort offers a glimpse into the past with its rich cultural vibes. Explore scenic trails and enjoy the views where the Mississippi and Ohio Rivers converge, making it a perfect spot for history buffs and nature lovers alike.
  • Ballard Wildlife Management Area: Located 5 miles from Cairo, this preserve is a haven for wildlife enthusiasts. Experience its historical significance while enjoying budget-friendly outdoor activities like bird watching, hiking, and exploring diverse habitats.
  • Columbus-Belmont State Park: Situated 17 miles away, this national park is an adventure seeker’s dream. With breathtaking scenery and plenty of outdoor activities like hiking, fishing, and picnicking, it promises a memorable experience in nature.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighAverage
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois, is convenient with several nearby airports. Paducah, KY (PAH-Barkley Regional), located 23 miles away, offers hotel options like The Respite Bed and Breakfast, Harrah's Metropolis Hotel & Casino, and The 1857. Marion, IL (MWA-Williamson County Regional) is 52 miles from Cairo, with hotels including Drury Inn & Suites Marion and Holiday Inn Express Hotel & Suites Marion Northeast. Cape Girardeau, MO (CGI-Cape Girardeau Municipal), 26 miles away, features Drury Plaza Hotel and Courtyard by Marriott Cape Girardeau Downtown. Each airport provides various transportation options to easily access your accommodations.

Frequently asked questions

What are the best hotels in Cairo that travelers recommend?
For travelers seeking a recommended hotel in Cairo, Illinois, the Quality Inn Cairo I-57 is a frequently praised option.

This hotel offers a range of convenient amenities, including air conditioning, a complimentary full breakfast, and free self-parking, including accessible parking and space for vans, RVs, buses, and trucks. Guests consistently comment on the nice, clean rooms, the quite good breakfast, and the helpful staff. While in Cairo, you will be within a reasonable distance of the Mississippi River and the Ohio River.
What are the best family hotels in Cairo?
For families visiting Cairo, a highly-rated option is the Quality Inn Cairo I-57.

This hotel offers several amenities designed to make family stays comfortable, including complimentary cribs upon request, free full breakfast, and free WiFi access. Guests often note the nice, clean rooms and the quite good breakfast options. The staff is also frequently praised for being nice and helpful. Find more child-friendly accommodations in Cairo
What hotels in Cairo offer free breakfast?
For hotels in Cairo that offer free breakfast, consider the Quality Inn Cairo I-57.

This hotel provides a complimentary full breakfast daily, which guests describe as quite good. It also offers free WiFi and free self-parking for added convenience. The rooms are noted by guests as being nice and clean, and the staff is frequently mentioned as being welcoming. Find more hotels with free breakfast in Cairo
What are the top pet-friendly hotels in Cairo?
For pet-friendly accommodations in Cairo, the Quality Inn Cairo I-57 is a highly recommended option.

This hotel welcomes pets, specifically dogs, making it a convenient choice for travelers with furry companions. Guests often mention the nice and clean rooms, the quite good breakfast, and the helpful staff. It also offers a complimentary full breakfast, a welcome amenity for starting your day. See more pet-friendly hotels in Cairo
What are the best budget hotels in Cairo?
For a budget-friendly option in Cairo, consider the Quality Inn Cairo I-57.

This hotel offers convenient amenities such as complimentary WiFi, free toiletries, and free self-parking. Guests particularly appreciate the free full breakfast, which often receives praise for being quite good. The rooms are frequently described as nice and clean, and the staff are often noted for being helpful.
What are the best hotels in Cairo near Mississippi River?
For hotels in Cairo near the Mississippi River, the Quality Inn Cairo I-57 is a great option.

The Quality Inn Cairo I-57 offers a range of complimentary amenities including free breakfast, free WiFi, and free self-parking. Guests consistently praise the nice, clean rooms and the quite good breakfast. The staff are also noted for being nice and helpful. For families, the hotel provides a free crib.
When is the best time to go to Cairo?
When planning a visit to Cairo, Illinois, the best times to go are during the spring and fall months.

These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for exploring the town's historic sites and natural surroundings. Spring, from April to May, brings blooming foliage and mild days, while fall, from September to October, provides crisp air and colorful landscapes.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Cairo.
How can I save on a Cairo hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Cairo hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Cairo hotel?
Prices for hotels in Cairo often vary, but you can find a great deal from $67 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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