Title: South Carolina Midlands, SC Inns from $75 | Expedia.com

[South Carolina Midlands Travel Guide](https://expedia.com/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.com/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.com/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.com/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.com/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[Car Rentals in South Carolina Midlands](https://expedia.com/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.com/South-Carolina-Midlands.d6057938.Destination-Travel-Guides)

![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

Next weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-02-27&endDate=2026-03-01&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In one month

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-03-20&endDate=2026-03-22&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-04-17&endDate=2026-04-19&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

No exact matches found, but these alternatives could be just right

## Recommended hotels in South Carolina Midlands

![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds | Free cribs/infant beds, free rollaway beds, bed sheets](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/949b4986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/fcf4fdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Latta by IHG

[](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information)

Latta

9.4/10

Exceptional

(553 reviews)

"Front desk is amazing! Rooms are clean and quiet. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kimberly

$118 nightly

$129 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/99021580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business center](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru By Hilton Santee

[](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

Santee

9.2/10

Wonderful

(724 reviews)

"Large, clean room, friendly staff, nice breakfast. Would stay again. Also a nice Mexican restaurant nearby for dinner. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan

$110 nightly

$122 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Santee

[](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information)

Santee

9.8/10

Exceptional

(1,006 reviews)

"Room had everything we wanted... very clean & fresh, microwave, fridge, comfy beds. Hotel was very nice and close to everything needed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marcia

$121 nightly

$134 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/b23b9566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/f9325683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/726f3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Inn on the Square, an Ascend Collection Hotel

[](https://www.expedia.com/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information)

Uptown Greenwood

9.2/10

Wonderful

(716 reviews)

"It was a very clean and beautiful lace to stay. We were there for our honeymoon "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy

$106 nightly

$117 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking | Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Florence Center Area

[](https://www.expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information)

Florence

9.2/10

Wonderful

(1,229 reviews)

"Room was very nice "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew

$97 nightly

$108 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/044c704d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Santee Inn

[](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

Santee

8.8/10

Excellent

(1,002 reviews)

"Nice rooms and very good breakfast items."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

$112 nightly

$124 total

Feb 17 - Feb 18

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Santee

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

Santee

8.0/10

Very Good

(1,431 reviews)

"Room were very clean and staff was very helpful. I would stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Charolette

$75 nightly

$83 total

Feb 17 - Feb 18

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/a1a27db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/21565fcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/e94102a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/16d0ef5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lexington Expo Hotel by IHG

[](https://www.expedia.com/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information)

Lexington

9.2/10

Wonderful

(1,002 reviews)

"Great location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Konrad

$113 nightly

$125 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2f1f8cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/1aef51e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![LCD TV](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/bea66887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/5f4afc1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Rock Hill

[](https://www.expedia.com/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information)

Rock Hill

9.2/10

Wonderful

(1,002 reviews)

"We have stayed here several times and it never disappoints! Room is clean, staff very friendly, and they provide a great breakfast!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Erma

$89 nightly

$99 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/713b3c0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/55a9de69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/0ec38ec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, Multiple Beds | Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/cff7c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Springhill Suites by Marriott Columbia near Fort Jackson

[](https://www.expedia.com/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information)

Columbia

9.4/10

Exceptional

(618 reviews)

"Great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Howard

$98 nightly

$110 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/ffaddd2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9f09eded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/bdf580c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

[](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information)

Florence

8.6/10

Excellent

(1,010 reviews)

"Friendly staff, quick check in, nice lobby"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

$122 nightly

$137 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information)

![Outdoor banquet area](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/2fa2ba7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/2a082860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/2d8379fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/22dee554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Crowne Plaza North Augusta by IHG

[](https://www.expedia.com/Aiken-Hotels-Crowne-Plaza-North-Augusta.h29853240.Hotel-Information)

North Augusta

8.8/10

Excellent

(865 reviews)

"Great room and great staff. My favorite staycation spot."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

cedric

$132 nightly

$148 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Aiken-Hotels-Crowne-Plaza-North-Augusta.h29853240.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/2db4f7f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/b50995e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/470d616b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn by Wyndham Columbia SE / Fort Jackson

[](https://www.expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information)

Columbia

7.8/10

Good

(1,004 reviews)

"I really enjoyed our stay , beds were very comfortable we slept like babies. Very quiet place , staff was very helpful and kind. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ranetta Whitton

$81 nightly

$90 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking (1st Floor) | Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/f9691b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking | 1 bedroom, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/e7174d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Howard Johnson by Wyndham Florence

[](https://www.expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

Florence

8.6/10

Excellent

(2,571 reviews)

"I nice place to stay, very quiet, good breakfast, nice staff, spotless room. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Timothy

$67 nightly

$75 total

Feb 17 - Feb 18

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/0e00b7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/e2ea309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place Florence Downtown

[](https://www.expedia.com/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information)

Florence

9.0/10

Wonderful

(1,005 reviews)

"Great location and well maintained property. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

$100 nightly

$112 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-51e671c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-d38b71cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed with Sofa bed, Non Smoking, Refrigerator & Microwave (with Sofabed) | Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-92efb678.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-cd66557b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Lexington Inn

[](https://www.expedia.com/Columbia-Hotels-Best-Western-Plus-Lexington-Inn.h250862.Hotel-Information)

Downtown Lexington

9.2/10

Wonderful

(1,000 reviews)

"Great stay good price"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeff

$100 nightly

$111 total

Feb 17 - Feb 18

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Best-Western-Plus-Lexington-Inn.h250862.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/6106ae70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/25ca9138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/99038ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/9c5dea2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Columbia Killian Road

[](https://www.expedia.com/Columbia-Hotels-Hampton-Inn-Suites-Columbia-Killian-Road.h31356801.Hotel-Information)

Columbia

9.2/10

Wonderful

(1,032 reviews)

"Great hotel with a convenient location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

vielka

$114 nightly

$128 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Columbia-Hotels-Hampton-Inn-Suites-Columbia-Killian-Road.h31356801.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/eb4d1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton Orangeburg

[](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

Orangeburg

9.2/10

Wonderful

(1,003 reviews)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

$114 nightly

$127 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

![Free breakfast](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/fcd98400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking | Iron/ironing board, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/1ffbf2b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5472b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Santee-I-95

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

Santee

9.6/10

Exceptional

(1,003 reviews)

"Liked the size of the room, the staff and the breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Virginia

$119 nightly

$133 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/47b4af62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/5bdd7f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds | Private kitchenette | Fridge, microwave](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/60d574cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/15b3bfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Southern Lodge 601

[](https://www.expedia.com/Orangeburg-Hotels-Southern-Lodge-601.h125185326.Hotel-Information)

Orangeburg

2.0/10

(1 review)

"The room smelled. The tub leaked water all over the floor and it didn’t work. There were dead and living bugs on the floor. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Edward

$67 nightly

$74 total

Feb 17 - Feb 18

Total with taxes and fees

[](https://www.expedia.com/Orangeburg-Hotels-Southern-Lodge-601.h125185326.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-02&endDate=2026-03-03&regionId=6057938&adults=2&lodging=INN&sort=RECOMMENDED&openPlayBack=true)

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## Top South Carolina Midlands Hotel Reviews

![Wyndham Garden Columbia/Ft. Jackson](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/e6cbdb45_y.jpg)

### Wyndham Garden Columbia/Ft. Jackson

10/10 Excellent

"Everything about my stay was nice, the property was clean and how the court yard is set up with all the games. My room was nice and clean and the bed was very comfortable. The staff was very friendly and nice."

[](https://expedia.com/Columbia-Hotels-Hotel-Columbia-Inn-Suites.h77814689.Hotel-Information)

![Cambria Hotel Columbia Downtown The Vista](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/e2b9c83a_y.jpg)

### Cambria Hotel Columbia Downtown The Vista

10/10 Excellent

"Room was spotless and very nice. I couldn’t hear anyone in the rooms around us. Staff was excellent, very friendly and helpful! There was no parking but valet took care of us!"

[](https://expedia.com/Columbia-Hotels-Cambria-Hotel-Columbia-Downtown-The-Vista.h76599223.Hotel-Information)

![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg)

### Graduate by Hilton Columbia SC

10/10 Excellent

"The hotel was unique from lobby to room. Exceptionally clean and a fun place to stay. "

[](https://expedia.com/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information)

![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg)

### Hilton Garden Inn Columbia/Harbison

10/10 Excellent

"yes"

[](https://expedia.com/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information)

![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg)

### Park Inn by Radisson Florence, SC

10/10 Excellent

"Very clean. The staff was so friendly and helpful. The breakfast was great!!! I’ll definitely be back "

[](https://expedia.com/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information)

![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg)

### Howard Johnson by Wyndham Florence

10/10 Excellent

"Room was great and clean, staff friendly and helpful. "

[](https://expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg)

### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

10/10 Excellent

"Excelent service "

[](https://expedia.com/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information)

![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg)

### La Quinta Inn by Wyndham Columbia SE / Fort Jackson

10/10 Excellent

"I really enjoyed our stay , beds were very comfortable we slept like babies. Very quiet place , staff was very helpful and kind. "

[](https://expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information)

![Springhill Suites by Marriott Columbia near Fort Jackson](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/713b3c0a_y.jpg)

### Springhill Suites by Marriott Columbia near Fort Jackson

10/10 Excellent

"Outstanding "

[](https://expedia.com/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information)

## Find out more about South Carolina Midlands

## South Carolina Midlands Inns information

| Number of reviews | 19,760 |
| ----------------- | ------ |
| Accommodation     | 1 Inns |
| Lowest Price      | $75    |
| Highest Price     | $148   |

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- [Palmetto Falls Water Park ](https://www.expedia.com/Palmetto-Falls-Water-Park-Columbia.d553248621532657322.Vacation-Attraction)
- [Fort Jackson ](https://www.expedia.com/Fort-Jackson-Columbia.d6145263.Vacation-Attraction)
- [Visit Blythewood ](https://www.expedia.com/Blythewood.dx180657)

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