Title: South Carolina Midlands, SC Inns from $75 | Expedia.com [South Carolina Midlands Travel Guide](https://expedia.com/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.com/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.com/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.com/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.com/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[Car Rentals in South Carolina Midlands](https://expedia.com/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.com/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-04-10&endDate=2026-04-12&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-04-17&endDate=2026-04-19&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-05-01&endDate=2026-05-03&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6057938&startDate=2026-05-29&endDate=2026-05-31&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in South Carolina Midlands ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/fcf4fdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2a6d6c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG [](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) Latta 9.6/10 Exceptional (569 reviews) "Great visit to this site...convenient to food, gas, and the staff was so pleasant. Breakfast was very good and I would not hesitate to stay there again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheryl $106 nightly $116 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (780 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Preston $115 nightly $128 total May 4 - May 5 Total with taxes and fees [](https://www.expedia.com/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2f1f8cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/1aef51e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/bea66887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard king non smoking | In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/b241d6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Rock Hill [](https://www.expedia.com/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) Rock Hill 9.2/10 Wonderful (1,001 reviews) "Enjoyed the stay and was clean and the staff was very nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlotte $93 nightly $104 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/eb4d1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,006 reviews) "Great stay! " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Julie $114 nightly $127 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/f9325683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/2b6111ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/b23b9566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel [](https://www.expedia.com/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Uptown Greenwood 9.2/10 Wonderful (728 reviews) "Near to historic district. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandra $118 nightly $131 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/122000000/121300000/121299200/121299135/83c5bf12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cornwallis](https://images.trvl-media.com/lodging/122000000/121300000/121299200/121299135/4a5ed39f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/122000000/121300000/121299200/121299135/42250faa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/122000000/121300000/121299200/121299135/bb7985f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Everett [](https://www.expedia.com/Winnsboro-Hotels-Hotel-Everett.h121299135.Hotel-Information) Winnsboro $186 nightly $207 total Apr 14 - Apr 15 Total with taxes and fees [](https://www.expedia.com/Winnsboro-Hotels-Hotel-Everett.h121299135.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/044c704d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub | Desk, laptop workspace, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,002 reviews) "Great breakfast bar - beautiful location in golf course and easy parking. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicole $119 nightly $132 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/778f48dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/25ba1b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/0da1bc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/8b979844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Executive Inn [](https://www.expedia.com/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) Latta 8.2/10 Very Good (980 reviews) "The staff at check in and the staff at check out was wonderful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jackieann $106 nightly $116 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very Good (1,434 reviews) "Location was great for a one night stay over " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Silvana $80 nightly $89 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/e7174d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking (1st Floor) | Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/f9691b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence [](https://www.expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Florence 8.6/10 Excellent (2,610 reviews) "Very comfortable room and the hotel was close to the Interstate and many good trestaurants." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles $67 nightly $75 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/9cbe600c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/c563e2d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/976555a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/56d0510c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Richburg by IHG [](https://www.expedia.com/Rock-Hill-Hotels-Holiday-Inn-Express-Richburg.h39474840.Hotel-Information) Richburg 9.2/10 Wonderful (669 reviews) "It was clean and beds comfortable. Breakfast nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul $88 nightly $99 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Rock-Hill-Hotels-Holiday-Inn-Express-Richburg.h39474840.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,000 reviews) "Excellent hotel, clean rooms, great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roberta $130 nightly $144 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/fcd98400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5472b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Santee-I-95 [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) Santee 9.6/10 Exceptional (1,002 reviews) "Very clean & the breakfast staff was very courteous." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Helen $125 nightly $139 total Apr 20 - Apr 21 Total with taxes and fees [](https://www.expedia.com/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bed9bec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bb785af0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/a4b552f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/4e5c59d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lexington Columbia [](https://www.expedia.com/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lexington 9.8/10 Exceptional (631 reviews) "Wonderful stay! Room was very clean and staff was super friendly and welcoming. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura $126 nightly $140 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/b50995e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/470d616b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/3fbd24c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson [](https://www.expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) Columbia 7.8/10 Good (1,004 reviews) "Free parking and breakfast was exceptional!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) abla $82 nightly $91 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/a1a27db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/abbeba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/16d0ef5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/e94102a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lexington Expo Hotel by IHG [](https://www.expedia.com/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information) Lexington 9.0/10 Wonderful (1,001 reviews) "clean and staff very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denard $106 nightly $118 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.0/10 Wonderful (1,242 reviews) "Clean room, good breakfast...very nice overnight stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gerry $98 nightly $109 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/120000000/119680000/119676100/119676039/23d48349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/120000000/119680000/119676100/119676039/b686e64e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/120000000/119680000/119676100/119676039/d4e7d592.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119680000/119676100/119676039/w3838h2158x2y2-63180063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lantern Columbia [](https://www.expedia.com/Columbia-Hotels-The-Lantern-Columbia.h119676039.Hotel-Information) Downtown Columbia 10/10 Exceptional (39 reviews) "Wonderful place to stay and staff is incredible. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donna $170 nightly $190 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Columbia-Hotels-The-Lantern-Columbia.h119676039.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/0ca73b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e4316a7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Manning [](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) Manning 8.6/10 Excellent (1,002 reviews) "Only stayed 2 nights. It was clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel $99 nightly $110 total Apr 6 - Apr 7 Total with taxes and fees [](https://www.expedia.com/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/bdf580c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/689a1cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG [](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Florence 8.6/10 Excellent (1,001 reviews) "The stay was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianne $125 nightly $140 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-18&endDate=2026-04-19®ionId=6057938&adults=2&lodging=INN&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Inns.d6057938-aaInns.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Inns.d6057938-aaInns.Travel-Guide-Accommodation) ## Top South Carolina Midlands Hotel Reviews ![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166_y.jpg) ### Hyatt Place Florence Downtown 10/10 Excellent "Nice clean room for family of 4 " [](https://expedia.com/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Delta Hotels by Marriott Columbia Northeast](https://images.trvl-media.com/lodging/1000000/10000/1400/1400/0044f7dd_y.jpg) ### Delta Hotels by Marriott Columbia Northeast 6/10 Okay "Very clean property and the Mexican restaurant was amazing!! Only qualm was zero hot water for the shower or sink. Street noisy outside at night with cars racing. " [](https://expedia.com/Columbia-Hotels-Delta-Hotels-Columbia-Northeast.h1400.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 8/10 Good "Although there was an added charge, it was a nice change to have real eggs in a delicious omelet." [](https://expedia.com/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 8/10 Good "Lots of rooms in multi buildings. Did not see an elevator so not great if in wheelchair, which I am not so I didn't mind the steps. Easy check in and out, friendly staff in a good loacation (I95 and I20). " [](https://expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg) ### Park Inn by Radisson Florence, SC 8/10 Good "Breakfast and AC were very good" [](https://expedia.com/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg) ### Comfort Inn & Suites Florence Center Area 8/10 Good " Breakfast was late " [](https://expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 8/10 Good "The shower and bath towels were awesome! The parking behind the hotel was ok, very crowded. The breakfast looked really good, but the eggs and sausage were not real warm. Staff was nice" [](https://expedia.com/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 2/10 Terrible "2p arrived early to hotel- rooms on not ready Checked in and ate lunch. 3p checked at front desk again for room - not ready. 4:15 checked again at front desk. Attendant called housekeeping and told them there are people waiting for room and if it could be prioritized (1st time anyone contacted housekeeping after us being there over 2 hours). Poorly run hotel 5p arrived in room. " [](https://expedia.com/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Clarion Pointe Rock Hill Near University](https://images.trvl-media.com/lodging/1000000/30000/22100/22006/70afa25a_y.jpg) ### Clarion Pointe Rock Hill Near University 8/10 Good "Easy access to anything you might need. Friendly staff and nice breakfast selection " [](https://expedia.com/Rock-Hill-Hotels-Clarion-Pointe-Rock-Hill-Near-Training-Camp.h22006.Hotel-Information) ## Find out more about South Carolina Midlands ## South Carolina Midlands Inns information | Number of reviews | 18,701 | | ----------------- | ------ | | Accommodation | 1 Inns | | Lowest Price | $75 | | Highest Price | $207 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Plex Indoor Sports ](https://www.expedia.com/Plex-Indoor-Sports-Hotels.0-l553248621532657324-0.Travel-Guide-Filter-Hotels) - [Hotels near Village at Sandhill Mall ](https://www.expedia.com/Village-At-Sandhill-Mall-Hotels.0-l6157983-0.Travel-Guide-Filter-Hotels) - [Apartments in Royal Pines Estates ](https://www.expedia.com/Royal-Pines-Estates-Apartments.d3000008081-aaApartments.Travel-Guide-Accommodation) - [B&B in Royal Pines Estates ](https://www.expedia.com/Royal-Pines-Estates-Bed-And-Breakfast.d3000008081-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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[Village at Sandhill Mall ](https://www.expedia.com/Village-At-Sandhill-Mall-Columbia.d6157983.Vacation-Attraction) - [Sesquicentennial State Park ](https://www.expedia.com/Sesquicentennial-State-Park-Columbia.d6157980.Vacation-Attraction) - [Visit Royal Pines Estates ](https://www.expedia.com/Royal-Pines-Estates.dx3000008081) - [Visit Woodfield ](https://www.expedia.com/Woodfield.dx6348005) - [Visit Dentsville ](https://www.expedia.com/Dentsville.dx6345142) - [Columbia Place Mall ](https://www.expedia.com/Columbia-Place-Mall-Columbia.d6157985.Vacation-Attraction) - [Hilton Field ](https://www.expedia.com/Hilton-Field-Columbia.d553248628697942700.Vacation-Attraction) - [Visit Elgin ](https://www.expedia.com/Elgin.dx6051125) - [Palmetto Falls Water Park ](https://www.expedia.com/Palmetto-Falls-Water-Park-Columbia.d553248621532657322.Vacation-Attraction) - [Fort Jackson ](https://www.expedia.com/Fort-Jackson-Columbia.d6145263.Vacation-Attraction) - [Visit Blythewood ](https://www.expedia.com/Blythewood.dx180657) - 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