$157 Cheap American Airlines flights Minneapolis (MSP) to San Francisco (SFO)

Finding cheap one-way American Airlines flights from MSP to SFO from $157 on Expedia is a breeze --- just filter by "Price (lowest to highest)." Or check out our affordable return fares from $279 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable American Airlines flights from Minneapolis - St. Paul Intl. Airport (MSP) to San Francisco Intl. Airport (SFO) one to three months ahead of your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and journey, the best day of the week to book a domestic flight is generally Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from MSP to SFO with American Airlines, filter your search by "Morning" and "Early Morning." Booking an early flight usually means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.