$521 Cheap Flights from Santiago (SCL) to Knoxville (TYS)

View $521 flight on Sun, Mar 8, 2026Opens in a new window

Popular airlines from Santiago Intl. Airport (SCL) to McGhee Tyson Airport (TYS)

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Cheap Flights from Santiago to Knoxville (SCL-TYS)

Prices were available within the past 7 days and start at $521 for one-way flights and $739 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$739 Roundtrip, found 23 hours ago
$739
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $739 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$740 Roundtrip, found 23 hours ago
$740
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $740 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$744 Roundtrip, found 23 hours ago
$744
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $744 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$745 Roundtrip, found 23 hours ago
$745
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $745 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$746 Roundtrip, found 23 hours ago
$746
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $746 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$749 Roundtrip, found 23 hours ago
$749
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $749 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$750 Roundtrip, found 23 hours ago
$750
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $750 found 23 hours ago
LATAM Airlines Group
Tue, Oct 14 - Thu, Oct 23
SCL
Santiago
TYS
Knoxville
$750 Roundtrip, found 23 hours ago
$750
Roundtrip
found 23 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Santiago to Knoxville, returning Thu, Oct 23, priced at $750 found 23 hours ago
Delta
Wed, Apr 1 - Fri, Apr 10
SCL
Santiago
TYS
Knoxville
$794 Roundtrip, found 2 days ago
$794
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Apr 1 from Santiago to Knoxville, returning Fri, Apr 10, priced at $794 found 2 days ago
American Airlines
Wed, Apr 1 - Fri, Apr 10
SCL
Santiago
TYS
Knoxville
$849 Roundtrip, found 2 days ago
$849
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Apr 1 from Santiago to Knoxville, returning Fri, Apr 10, priced at $849 found 2 days ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $774
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $774

Frequently asked questions

How much does a flight from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS) cost?
Grab a cheap one-way flight from $521 or cheap return flight from $739 from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS)?
Traveling in October is a great way to save, as it's the cheapest month for flights between SCL and TYS. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest SCL to TYS flight.
How many flights per day from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS)?
There aren't any daily direct flights departing from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from SCL to TYS?
Usually you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS)?
Book a flight from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the likelihood of delays. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS) last-minute?
Last-minute fares from SCL to TYS are usually more expensive. For the lowest prices, start looking for flights as soon as possible. That being said, if you're flexible with your travel plans, it's possible to land a cheap fare right before you leave.
Is it cheaper to book a SCL to TYS flight and hotel package?
Opting for a SCL to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our impressive range of hotels and then add car rentals, activities and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Arturo Merino Benitez Airport (SCL) to McGhee Tyson Airport (TYS)?
Typically, you're able to cancel or reschedule your SCL to TYS flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you need further details, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Arturo Merino Benitez
Destination airport
McGhee Tyson
Airlines serving
LATAM Airlines Group
Roundtrip price
$739
Distance
4856 mi

Book with confidence

Book with confidence

Santiago to Knoxville Flights

The cheapest times to fly from Santiago to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Knoxville are during the month of October. You can find some of the cheapest flights from Santiago to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santiago to Knoxville

Sunday is one of the best days to book for cheap flights from Santiago to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santiago to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $521 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santiago to Knoxville Flights

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*Available to One Key members.