Find 4 Star Hotels in Clayton, MO from $105

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Our top choices for Clayton 4-star hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1147)
"So pleased with my stay would definitely recommend! Affordable and exclusive, staff ensured my stay was immaculate!"
United States
Meli
$93 nightly
The price is $111
Dec 25 - Dec 26
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Hyatt Regency St. Louis at The Arch

4.0 star property
Downtown St. Louis
8.4 out of 10, Very Good, (3999)
"Arch view room is big and comfortable fantastic. . "
United States
Tim
$89 nightly
The price is $105
Dec 21 - Dec 22
Total with taxes and fees
Hyatt Regency St. Louis at The Arch

Hilton St. Louis Frontenac

4.0 star property
Frontenac
8.8 out of 10, Excellent, (1000)
"Clean room, felt like a mini apartment! The surrounding was beautiful. "
United States
Jane
$130 nightly
The price is $152
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hilton St. Louis Frontenac

21C Museum Hotel St Louis

4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1489)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
$131 nightly
The price is $153
Jan 4 - Jan 5, 2026
Total with taxes and fees
21C Museum Hotel St Louis

The Cheshire

4.0 star property
Richmond Heights
8.6 out of 10, Excellent, (1000)
"Excellent place to stay. "
United States
Todd
$115 nightly
The price is $137
Dec 29 - Dec 30
Total with taxes and fees
The Cheshire

Renaissance St. Louis Airport Hotel

4.0 star property
Berkeley
8.4 out of 10, Very Good, (1056)
"Staff was courteous and the room was clean."
United States
Mia
$118 nightly
The price is $138
Dec 20 - Dec 21
Total with taxes and fees
Renaissance St. Louis Airport Hotel

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4.0 star property
Grand Center
8.8 out of 10, Excellent, (1031)
"This was a wonderful first experience at a beautiful hotel with such friendly staff. We will definitely stay here again!"
United States
Alexis
$119 nightly
The price is $141
Dec 15 - Dec 16
Total with taxes and fees
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Live by Loews - St.Louis

4.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1101)
"Great staff"
United States
Phillip
$149 nightly
The price is $177
Dec 14 - Dec 15
Total with taxes and fees
Live by Loews - St.Louis

The Westin St. Louis

4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1005)
"Great location "
United States
Gregory
$127 nightly
The price is $148
Dec 18 - Dec 19
Total with taxes and fees
The Westin St. Louis

Ameristar Casino Resort and Spa

4.5 star property
St. Charles
8.4 out of 10, Very Good, (1003)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
$166 nightly
The price is $194
Dec 14 - Dec 15
Total with taxes and fees
Ameristar Casino Resort and Spa

DoubleTree by Hilton St. Louis Forest Park

4.0 star property
Central West End
8.2 out of 10, Very Good, (1000)
"Great room "
United States
Jessica
$114 nightly
The price is $134
Dec 21 - Dec 22
Total with taxes and fees
DoubleTree by Hilton St. Louis Forest Park

River City Casino & Hotel

4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1450)
"Awesome place to stay!!"
United States
Kaitlyn
$95 nightly
The price is $111
Dec 17 - Dec 18
Total with taxes and fees
River City Casino & Hotel

St. Louis Union Station Hotel, Curio Collection by Hilton

4.0 star property
Downtown West
8.4 out of 10, Very Good, (1006)
"Nice historic hotel"
United States
Michelle
$142 nightly
The price is $169
Dec 18 - Dec 19
Total with taxes and fees
St. Louis Union Station Hotel, Curio Collection by Hilton

Marriott St. Louis Grand

4.0 star property
Downtown St. Louis
8.2 out of 10, Very Good, (1008)
"Everything was excellent "
United States
Josh
$127 nightly
The price is $151
Dec 17 - Dec 18
Total with taxes and fees
Marriott St. Louis Grand

Moonrise Hotel

4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (1912)
"Great service, unique hotel. Would absolutely stay again!"
United States
Michael
$150 nightly
The price is $178
Dec 18 - Dec 19
Total with taxes and fees
Moonrise Hotel

Marriott St. Louis Airport

4.0 star property
Edmundson
8.0 out of 10, Very Good, (1001)
"Love that there is a restaurant inside the property so that after you check in you do not have to go elsewhere to find a place to eat. "
United States
Susan
$128 nightly
The price is $152
Dec 19 - Dec 20
Total with taxes and fees
Marriott St. Louis Airport

Hilton Pennywell St. Louis at the Arch

4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1013)
"My second time staying there as always it was lovely "
United States
Nina
$103 nightly
The price is $122
Dec 19 - Dec 20
Total with taxes and fees
Hilton Pennywell St. Louis at the Arch

Le Méridien St. Louis Clayton

4.0 star property
Clayton
8.8 out of 10, Excellent, (675)
"Small rooms but beautiful lobby. "
United States
Debbie
$119 nightly
The price is $140
Dec 19 - Dec 20
Total with taxes and fees
Le Méridien St. Louis Clayton

DoubleTree by Hilton St. Louis - Westport

4.0 star property
Maryland Heights
8.2 out of 10, Very Good, (1002)
"Stayed one night felt very safe here"
United States
William
$110 nightly
The price is $127
Dec 28 - Dec 29
Total with taxes and fees
DoubleTree by Hilton St. Louis - Westport

Embassy Suites by Hilton St. Louis Downtown

4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1241)
"Great hospitality"
United States
Alejandro
$107 nightly
The price is $127
Dec 17 - Dec 18
Total with taxes and fees
Embassy Suites by Hilton St. Louis Downtown
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Explore similar 5-star hotels

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Top Clayton Hotel Reviews

Find out more about Clayton

The beginning of any trip gets started with picking a fantastic spot. Clayton has become a popular local with guests because of all its local amenities. However, "location, location, location" applies to more than just what city where your plane lands. When you want a holiday that is great from start to finish, you need the ideal hotel.

Hotels as Picturesque as Clayton

Clayton saw its fair share of visitors in the last year. Our comment section provides tips and tricks on which hotel will fulfill your wishes for an unbelievable vacation. The resorts found here aim to make your vacation as pleasant as your evenings spent hanging out in Clayton. These hotels aim to make their facilities and grounds pleasing from the time you step onto the property. You'll never have to venture far to sustain your exercise schedule, enjoy an energizing spa treatment, or find a delicious lunch during your vacation with all that they offer.

Rooms have been designed to keep you as cozy as possible, with amenities like in-room tea or coffee, specially designed bathroom products, and, premium bedding. So, lay back and unwind. Moreover, if you find that you're need of anything more, you can be confident the staff will do their best to ensure you continue to be pleased during your time. These hotels are so nice that you'll regret the day you have to check-out.

Reserve a 4-Star Hotel in Clayton Today!

A getaway to Clayton should be one where you don't have to concern yourself about the little things. Expedia can get great rates on world-class accommodations to take your trip to the next level.

Frequently asked questions

What are the best 4-star hotels in Clayton?
Kick back and unwind in 4-star hotel comfort at Le Méridien St. Louis Clayton. Rated highly by many of our guests, it offers concierge services and premium bedding. Also check out The Cheshire. Egyptian-cotton sheets and a terrace help make this escape another popular choice in Clayton.
How much does it cost to stay in a 4-star hotel in Clayton?
We can help you easily locate the perfect 4-star hotel for your trip to Clayton. Use our filter tool to tailor your search by things like budget, amenities and star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from $485

What's the difference between 5-star and 4-star hotels in Clayton?
Offering a welcoming guest experience and upscale décor, 4-star hotels are a fabulous option for your Clayton trip. These types of stays generally feature loads of useful amenities that make it easy to unpack and unwind — think 24-hour room service, gyms and pools. Or enjoy even more lavishness at a 5-star hotel designed to pamper with exclusive perks and amenities. 24-hour front desk, complimentary toiletries and gourmet dining are typically featured at these swanky properties.

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